INT11560

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2011
Negated 9
Speculated 7
Reported most in Abstract
Documents 236
Total Number 244
Disease Relevance 184.33
Pain Relevance 39.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CASP3) mitochondrion (CASP3) cytoplasm (CASP3)
cytosol (CASP3) peptidase activity (CASP3) nucleolus (CASP3)
Anatomy Link Frequency
cleavage 17
fibroblasts 7
apoptotic cell 5
poly 4
HL-60 4
CASP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 15 100.00 Very High Very High Very High
lidocaine 2 99.98 Very High Very High Very High
Inflammation 1619 99.92 Very High Very High Very High
qutenza 151 99.92 Very High Very High Very High
rheumatoid arthritis 809 99.84 Very High Very High Very High
Buprenorphine 7 99.84 Very High Very High Very High
isoflurane 56 99.82 Very High Very High Very High
Paracetamol 67 99.72 Very High Very High Very High
Morphine 18 99.70 Very High Very High Very High
dexamethasone 848 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 9161 100.00 Very High Very High Very High
Death 1307 100.00 Very High Very High Very High
Camurati-engelmann Disease 1 100.00 Very High Very High Very High
Hyperglycemia 192 99.98 Very High Very High Very High
INFLAMMATION 1712 99.92 Very High Very High Very High
Repression 105 99.90 Very High Very High Very High
Rheumatoid Arthritis 815 99.84 Very High Very High Very High
Skin Cancer 106 99.84 Very High Very High Very High
Rhinitis 131 99.82 Very High Very High Very High
Prostate Cancer 62 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, mesalazine induced apoptosis in colon cancer cells possibly through activation of caspase-3 whereas the levels of bcl-2 family proteins were not altered.
Spec (possibly) Positive_regulation (activation) of caspase-3 in colon associated with colon cancer and apoptosis
1) Confidence 0.70 Published 2003 Journal Carcinogenesis Section Abstract Doc Link 12663503 Disease Relevance 0.84 Pain Relevance 0.24
Treatment with capsaicin induced a dramatic increase in caspase 3 activity, as assessed by the cleavage of Ac-DEVD-AMC, a fluorogenic substrate.
Positive_regulation (increase) of caspase 3 in cleavage associated with qutenza
2) Confidence 0.69 Published 2009 Journal Cell. Mol. Biol. Lett. Section Abstract Doc Link 19381455 Disease Relevance 1.18 Pain Relevance 0.89
Differential upregulation of the apoptotic mediators p53, Bax, cytochrome c, and caspase-3 and -9, and downregulation of antiapoptotic Bcl-2, was observed in CP.
Positive_regulation (upregulation) of caspase-3
3) Confidence 0.67 Published 2008 Journal J. Gastroenterol. Section Body Doc Link 18600392 Disease Relevance 0.07 Pain Relevance 0
RESULTS: Treatment with curcumin and resveratrol suppressed NF-kappaB-regulated gene products involved in inflammation (cyclooxygenase-2, matrix metalloproteinase (MMP)-3, MMP-9, vascular endothelial growth factor), inhibited apoptosis (Bcl-2, Bcl-xL, and TNF-alpha receptor-associated factor 1) and prevented activation of caspase-3.
Positive_regulation (activation) of caspase-3
4) Confidence 0.67 Published 2009 Journal Arthritis Res. Ther. Section Body Doc Link 19889203 Disease Relevance 0.06 Pain Relevance 0
Eventually, neurons activate p53, caspase-3 and BAX, hallmarks of neuronal apoptosis, before they die.
Positive_regulation (activate) of caspase-3 in neuronal associated with neurodegenerative disease
5) Confidence 0.67 Published 2009 Journal J Neural Transm Section Abstract Doc Link 19565182 Disease Relevance 0.38 Pain Relevance 0.31
Finally, activation of pro-caspase 9 and procaspase 3 was also determined (Figs 2c and d).
Positive_regulation (activation) of procaspase 3
6) Confidence 0.67 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.76 Pain Relevance 0
Codeinone dose-dependently activated caspase-3 in both of these cells, but to a much lesser extent than that attained by actinomycin D.
Positive_regulation (activated) of caspase-3
7) Confidence 0.67 Published 2005 Journal Anticancer Res. Section Abstract Doc Link 16309196 Disease Relevance 0.43 Pain Relevance 0.12
Changes in apoptosis were examined using TdT-mediated dUTP-biotin nick end-labeling assay and by the immunoexpression of activated caspase-3 in tissues after GnRHa therapy.
Positive_regulation (activated) of caspase-3
8) Confidence 0.67 Published 2010 Journal Hum. Reprod. Section Body Doc Link 20008888 Disease Relevance 0.29 Pain Relevance 0
In addition, glyoxalase I inhibition leads to reduced cell viability, strongly retracted neuritis, increase in [Ca(2+)](i), and activation of caspase-3.
Positive_regulation (activation) of caspase-3 associated with neuritis
9) Confidence 0.67 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16555297 Disease Relevance 0.64 Pain Relevance 0.10
When compared with the non-treated group, a significant increase in apoptotic index (apoptotic cells per 10 mm(2) area) and quantitative-histogram scores of activated caspase-3 after GnRHa therapy were observed in the eutopic endometria, lesions and myometria of these diseases.
Positive_regulation (activated) of caspase-3 in apoptotic cells
10) Confidence 0.67 Published 2010 Journal Hum. Reprod. Section Body Doc Link 20008888 Disease Relevance 0.05 Pain Relevance 0
We previously reported that the morphine alkaloid derivative buprenorphine hydrochloride (Bph) induces rapid apoptosis in NG108-15 nerve cells accompanied by the activation of caspase-3.
Positive_regulation (activation) of caspase-3 in nerve cells associated with benign prostatic hypertrophy, apoptosis, buprenorphine and morphine
11) Confidence 0.67 Published 2004 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15340216 Disease Relevance 0.72 Pain Relevance 0.27
In HL-60 and MCF-7 cells this extract was a very strong inducer of cell death activating caspase-3 followed by PARP signature type cleavage.
Positive_regulation (inducer) of caspase-3 in MCF-7 associated with death
12) Confidence 0.67 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19287970 Disease Relevance 1.19 Pain Relevance 0.24
Either antioxidant tempol or a pancaspase inhibitor Z-VAD-FMK decreased cell death as well as caspase 3/7 activity induced by SLD sulfide/TNF coexposure.
Positive_regulation (induced) of caspase 3 associated with death
13) Confidence 0.67 Published 2010 Journal Toxicology Section Abstract Doc Link 20371263 Disease Relevance 0.94 Pain Relevance 0
Acetaminophen triggered the release of cytochrome c from mitochondria into the cytosol, activation of caspase-3, 8, and 9, cleavage of poly(ADP-ribose) polymerase, and degradation of lamin B1 and DNA.
Positive_regulation (activation) of caspase-3 in poly associated with paracetamol
14) Confidence 0.67 Published 2002 Journal Pharmacol. Toxicol. Section Abstract Doc Link 12005112 Disease Relevance 0.66 Pain Relevance 0.91
Growth inhibition by sulindac sulfide was associated with a significant increase in percent G cells and activation of caspase-3.
Positive_regulation (activation) of caspase-3 in G cells
15) Confidence 0.67 Published 2007 Journal Cancer Biol. Ther. Section Abstract Doc Link 17172818 Disease Relevance 0.37 Pain Relevance 0.08
The net result, regardless of the mechanism, is osteoclast apoptosis, notably through the induction of caspase-3.
Positive_regulation (induction) of caspase-3 in osteoclast associated with apoptosis
16) Confidence 0.67 Published 2001 Journal J Mammary Gland Biol Neoplasia Section Abstract Doc Link 12013536 Disease Relevance 1.31 Pain Relevance 0.26
Caspase-3 activation is the first step in the execution phase of apoptosis.
Positive_regulation (activation) of Caspase-3 associated with apoptosis
17) Confidence 0.62 Published 2008 Journal Chirality Section Abstract Doc Link 18092300 Disease Relevance 0.99 Pain Relevance 0.22
Caspase-3 activation was detected by Western blotting, fluorometric assay of DEVD-AMC cleavage, and flow cytometry with carboxyfluorescein (FAM) labeled caspase inhibitor.
Positive_regulation (activation) of Caspase-3 in cleavage
18) Confidence 0.62 Published 2008 Journal Chirality Section Abstract Doc Link 18092300 Disease Relevance 1.04 Pain Relevance 0.44
Capsaicin-induced apoptosis was associated with the elevation of intracellular reactive oxygen species and Ca2+ production, decreased the levels of mitochondrial membrane potential, promoted cytochrome c release and increased the activation of caspase-3.
Positive_regulation (activation) of caspase-3 associated with qutenza and apoptosis
19) Confidence 0.60 Published 2006 Journal Anticancer Res. Section Abstract Doc Link 16827131 Disease Relevance 0.66 Pain Relevance 0.76
Caspase-3 activation was measured with quantitative Western blotting.
Positive_regulation (activation) of Caspase-3
20) Confidence 0.54 Published 2006 Journal J. Gerontol. A Biol. Sci. Med. Sci. Section Body Doc Link 17234824 Disease Relevance 0.09 Pain Relevance 0

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