INT115608

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.19
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1a) signal transducer activity (Htr1a)
Anatomy Link Frequency
brain 2
nucleus 2
Htr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 2 99.84 Very High Very High Very High
depression 11 99.80 Very High Very High Very High
Antinociceptive 4 99.76 Very High Very High Very High
Serotonin 1 93.88 High High
fluoxetine 4 89.20 High High
Hyperalgesia 2 88.92 High High
cocaine 2 84.88 Quite High
agonist 2 76.56 Quite High
Raphe 2 74.96 Quite High
antidepressant 3 72.72 Quite High
Disease Link Frequency Relevance Heat
Depression 11 99.80 Very High Very High Very High
Hyperalgesia 2 88.92 High High
Neuropathic Pain 4 88.12 High High
Stress 14 82.88 Quite High
Urological Neuroanatomy 2 25.00 Low Low
Affective Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antinociceptive effects of inhibiting 5-HT1A receptor expression by intracerebroventricular administration of an antisense oligodeoxynucleotide were studied in mononeuropathic rats.
Negative_regulation (inhibiting) of Gene_expression (expression) of 5-HT1A associated with intracerebroventricular and antinociceptive
1) Confidence 0.57 Published 2004 Journal Int. J. Neurosci. Section Abstract Doc Link 14702210 Disease Relevance 0.24 Pain Relevance 0.30
Venlafaxine-induced depression of wind-up activity in mononeuropathic rats is potentiated by inhibition of brain 5-HT1A receptor expression in vivo.
Negative_regulation (inhibition) of Gene_expression (expression) of 5-HT1A in brain associated with depression
2) Confidence 0.57 Published 2004 Journal Int. J. Neurosci. Section Title Doc Link 14702210 Disease Relevance 0.28 Pain Relevance 0.42
The present investigation determined the levels of RGSZ1 in the hypothalamic paraventricular nucleus of rats subjected to four different treatment protocols that produce desensitization of 5-HT1A receptors.
Negative_regulation (desensitization) of Gene_expression (produce) of 5-HT1A in nucleus
3) Confidence 0.41 Published 2004 Journal Neuroscience Section Abstract Doc Link 15262317 Disease Relevance 0 Pain Relevance 0.17
More recently, several lines of evidence suggest that an important factor in the development of depression may be a deficit in the function and expression of 5-HT1A receptors.
Negative_regulation (deficit) of Gene_expression (expression) of 5-HT1A associated with depression
4) Confidence 0.41 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15554266 Disease Relevance 0.67 Pain Relevance 0.43

General Comments

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