INT115609

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Context Info
Confidence 0.15
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 1.83
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (ERBB2, SFRP5) signal transduction (ERBB2, SFRP5) plasma membrane (ERBB2, SFRP5)
cell differentiation (SFRP5) embryo development (SFRP5) cell proliferation (ERBB2)
Anatomy Link Frequency
terminal portion 1
ERBB2 (Homo sapiens)
SFRP5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 25.00 Low Low
Pain 2 25.00 Low Low
palliative 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Morphine 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Crohn's disease 3 5.00 Very Low Very Low Very Low
Infliximab 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pseudomonas Infection 3 96.64 Very High Very High Very High
Cancer 167 93.12 High High
Colon Cancer 2 71.76 Quite High
Skin Cancer 5 69.52 Quite High
Toxicity 51 59.68 Quite High
Advanced Or Metastatic Breast Cancer 9 53.00 Quite High
Prostate Cancer 12 49.44 Quite Low
Head & Neck Cancer 6 47.28 Quite Low
Lung Cancer 6 46.24 Quite Low
Death 6 45.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ScFv(FRP5)-ETA is a recombinant single-chain antibody-toxin with binding specificity for ErbB2/HER2.
HER2 Binding (specificity) of FRP5
1) Confidence 0.15 Published 2003 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 14703062 Disease Relevance 0.39 Pain Relevance 0
ScFv(FRP5)-ETA is a recombinant single-chain antibody-toxin with binding specificity for ErbB2/HER2.
ErbB2 Binding (specificity) of FRP5
2) Confidence 0.15 Published 2003 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 14703062 Disease Relevance 0.39 Pain Relevance 0
ScFv(FRP5)-ETA is a recombinant antibody toxin with binding specificity for ErbB2 (HER2).
HER2 Binding (specificity) of FRP5
3) Confidence 0.07 Published 2005 Journal Breast Cancer Res Section Abstract Doc Link PMC1242130 Disease Relevance 0.27 Pain Relevance 0
ScFv(FRP5)-ETA is a recombinant antibody toxin with binding specificity for ErbB2 (HER2).
ErbB2 Binding (specificity) of FRP5
4) Confidence 0.07 Published 2005 Journal Breast Cancer Res Section Abstract Doc Link PMC1242130 Disease Relevance 0.26 Pain Relevance 0
The N-terminal portion of the bacterially expressed molecule is contributed by a single-chain antibody fragment (scFv) derived from heavy-chain and light-chain variable domains of murine mAb FRP5, which recognizes the extracellular domain of human ErbB2 [11].
ErbB2 Binding (recognizes) of FRP5 in terminal portion
5) Confidence 0.06 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1242130 Disease Relevance 0.52 Pain Relevance 0

General Comments

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