INT115612

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Context Info
Confidence 0.17
First Reported 2003
Last Reported 2007
Negated 2
Speculated 2
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.27
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TFPI) extracellular region (TFPI) plasma membrane (TFPI)
Anatomy Link Frequency
EPI 6
SH-SY5Y 2
TFPI (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 3 100.00 Very High Very High Very High
Catecholamine 28 99.16 Very High Very High Very High
agonist 64 25.00 Low Low
Potency 16 22.28 Low Low
antagonist 36 7.72 Low Low
depression 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
antinociception 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 2 99.44 Very High Very High Very High
Neuroblastoma 32 93.52 High High
Aids-related Complex 12 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Hypertension 4 5.00 Very Low Very Low Very Low
Sleep Disorders 4 5.00 Very Low Very Low Very Low
Cv General 4 Under Development 4 5.00 Very Low Very Low Very Low
Depression 4 5.00 Very Low Very Low Very Low
Leukemia 4 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
2A-AR signaling [10], we wanted to determine whether the membrane recruitment of either GRK isoform was changed following chronic EPI exposure in SH?
Spec (whether) Regulation (changed) of Gene_expression (exposure) of EPI in EPI
1) Confidence 0.17 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0.04
Chronic EPI exposure does not alter GRK2 or GRK3 levels in whole cells but instead enhances GRK2 and GRK3 expression at the membrane in SH?
Neg (not) Regulation (alter) of Gene_expression (exposure) of EPI in EPI
2) Confidence 0.17 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0.07
Chronic EPI exposure altered neither GRK3 nor GRK2 levels in the transfected SH-SY5Y cell line (Table 4).
Neg (neither) Regulation (altered) of Gene_expression (exposure) of EPI in SH-SY5Y
3) Confidence 0.17 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0.05
2-AR responsiveness in cells and tissues after chronic epinephrine (EPI) or norepinephrine (NE) exposure may vary, depending on the ?
Spec (may) Regulation (depending) of Gene_expression (responsiveness) of EPI in EPI
4) Confidence 0.17 Published 2007 Journal BMC Pharmacol Section Abstract Doc Link PMC2234403 Disease Relevance 0.17 Pain Relevance 0
[Influence of immunization dose schemes on the immune response to anti-tetrodotoxin vaccine].
Regulation (response) of Gene_expression (vaccine) of anti-tetrodotoxin associated with tetrodotoxin and immunization
5) Confidence 0.01 Published 2003 Journal Zhonghua Yu Fang Yi Xue Za Zhi Section Title Doc Link 14703494 Disease Relevance 0.10 Pain Relevance 0.29

General Comments

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