INT115614

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 25
Total Number 28
Disease Relevance 8.97
Pain Relevance 9.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria2) endoplasmic reticulum (Gria2) plasma membrane (Gria2)
protein complex (Gria2)
Anatomy Link Frequency
neuronal 1
plasma 1
spinal 1
spine 1
neuron 1
Gria2 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 214 100.00 Very High Very High Very High
nMDA receptor 201 100.00 Very High Very High Very High
Glutamate 146 100.00 Very High Very High Very High
Pain 133 100.00 Very High Very High Very High
Neurotransmitter 26 100.00 Very High Very High Very High
qutenza 10 99.84 Very High Very High Very High
depression 101 99.64 Very High Very High Very High
Morphine 7 99.54 Very High Very High Very High
Kinase C 180 99.50 Very High Very High Very High
Neuropeptide 10 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 101 99.64 Very High Very High Very High
Autism 56 99.04 Very High Very High Very High
Inflammatory Pain 90 98.84 Very High Very High Very High
Hyperalgesia 61 98.42 Very High Very High Very High
Disease 52 98.28 Very High Very High Very High
Nociception 272 98.04 Very High Very High Very High
Pain 120 96.28 Very High Very High Very High
Targeted Disruption 284 96.04 Very High Very High Very High
Anxiety Disorder 50 95.92 Very High Very High Very High
Hypersensitivity 83 95.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of Non-PDZ domain-containing protein, such as N-ethylmaleimide sensitive fusion (NSF) protein (an ATPase), in neuronal membrane fusion processes and regulatory interaction with GluR2 and GluR3 subunits of AMPA receptors has been investigated.
GluR2 Binding (interaction) of in neuronal
1) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.28 Pain Relevance 0.27
Regulation of the interactions between AMPA receptor subunits and associated partner proteins in spinal cord neurons during nociception
AMPA receptor Binding (interactions) of in spinal cord neurons associated with nociception and spinal cord
2) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.50 Pain Relevance 0.22
A case of autism with an interstitial deletion on 4q leading to hemizygosity for genes encoding for glutamine and glycine neurotransmitter receptor sub-units (AMPA 2, GLRA3, GLRB) and neuropeptide receptors NPY1R, NPY5R

Background

AMPA 2 Binding (hemizygosity) of associated with neurotransmitter, autism and neuropeptide
3) Confidence 0.34 Published 2004 Journal BMC Med Genet Section Title Doc Link PMC411038 Disease Relevance 0.73 Pain Relevance 0.10
This phosphorylation of GluR2 on Serine880 may further impede the affinity of GluR2 for GRIP, release GluR2 from GRIP-GluR2 complex and finally lead to the internalization of GluR2 subunits.
GluR2 Binding (complex) of
4) Confidence 0.33 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.33 Pain Relevance 0.21
In vitro studies on hippocampal slices show that AMPA receptors can be directly phosphorylated on at least 12 distinct phosphorylation sites.
AMPA Binding (receptors) of
5) Confidence 0.33 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.09 Pain Relevance 0.20
On one hand, PICK1 can dimerise and the dimers may induce the aggregation of AMPA receptors in heterologous expression systems [44].
AMPA Binding (aggregation) of
6) Confidence 0.33 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.45 Pain Relevance 0.26
The phosphorylation of GluR2 subunit at Serine880 by PKC may lead to disrupt the interaction between GluR2 and GRIP and follow by GluR2 internalization.
GluR2 Binding (interaction) of associated with kinase c
7) Confidence 0.33 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.60 Pain Relevance 0.50
The rapid alterations in the composition of synaptic AMPA receptors induced by physiologic activity or noxious stimuli can be achieved by modulating the phosphorylation status of GluR1 and GluR2 subunits and their binding to PDZ domain-containing synaptic scaffolding proteins.
GluR2 Binding (binding) of
8) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 1.01 Pain Relevance 0.65
In the past decades, it has been demonstrated that a number of proteins interact with the intracellular C-termini of postsynaptic AMPA receptor GluR1-4 subunits.
AMPA receptor Binding (interact) of
9) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.46 Pain Relevance 0.21
In summary, the interaction of AMPA receptor subunits with their partner proteins was extensively involved in the processes of the regulation of post-translational modification, such as trafficking, internalization and surface expression.
AMPA receptor Binding (interaction) of
10) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.34 Pain Relevance 0.38
It subsequently disrupted the binding of GluR2 subunits to synaptic anchoring protein (GRIP) and result in a switch of GluR2-containing AMPA receptors to GluR2-lacking AMPA receptors.
GluR2 Binding (binding) of
11) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.93 Pain Relevance 0.64
2 exists primarily as a homomeric receptor and that at least a portion is closely associated with AMPA or kainate receptors.
AMPA Binding (associated) of
12) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2666267 Disease Relevance 0.07 Pain Relevance 0.04
RT-PCR primers used in this study are as follows: GluR2 forward, 5'-CCATGAAAGTGGGAGGTAACTTG-3'; GluR2 reverse, 5'-AAGCCCCTGCTCGTTCAGT-3'; ADAR2 forward, 5'-TGTAAGCACGCGCTGTACTGT-3'; ADAR2 reverse, 5'-GACTCGTGGTATGTGGTAGGCTTAG-3'; ?
GluR2 Binding (follows) of
13) Confidence 0.20 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 0 Pain Relevance 0
In vivo recruitment by painful stimuli of AMPA receptor subunits to the plasma membrane of spinal cord neurons.
AMPA Binding (recruitment) of in plasma associated with pain, qutenza and spinal cord
14) Confidence 0.11 Published 2004 Journal Pain Section Title Doc Link 15561387 Disease Relevance 0.45 Pain Relevance 1.03
Here we have induced referred mechanical hyperalgesia in vivo by intracolonic instillation of capsaicin in mice and have observed a recruitment of GluR1 AMPA-R subunits to neuronal plasma membranes in the lumbar spinal cord.
AMPA-R Binding (recruitment) of in spinal cord associated with hyperalgesia, qutenza and spinal cord
15) Confidence 0.11 Published 2004 Journal Pain Section Abstract Doc Link 15561387 Disease Relevance 0.45 Pain Relevance 1.08
Furthermore, they may attribute to hippocampal LTD by affecting the trafficking of AMPA receptor through the interaction with clathrin adaptor protein 2 complex and protein interacting with C kinase, respectively [56,57].


AMPA receptor Binding (trafficking) of associated with depression
16) Confidence 0.05 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.82 Pain Relevance 0.86
Propofol produced antinociception through an interaction with spinal NMDA and AMPA receptors in mice.


AMPA Binding (interaction) of in spinal
17) Confidence 0.05 Published 2004 Journal Acta Pharmacol. Sin. Section Body Doc Link 14704116 Disease Relevance 0 Pain Relevance 0
Therefore, the loss of LTD may arise from impaired functions of NMDA receptor but not AMPA receptor and the reduced NMDA receptor function may be due to the constitutive binding of mutant DREAM with PSD-95.


AMPA receptor Binding (binding) of associated with depression and nmda receptor
18) Confidence 0.05 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.41 Pain Relevance 0.26
However, AMPA receptor trafficking to the synapse is critical to sustain LTP and spine expansion.
AMPA receptor Binding (trafficking) of in synapse associated with long-term potentiation
19) Confidence 0.03 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0 Pain Relevance 0.21
We carried out immunolabeling for GluR1 (an AMPA receptor subunit) and quantified GluR1-immunoreactive puncta (Figures 4A-G).
AMPA receptor Binding (immunolabeling) of
20) Confidence 0.03 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0 Pain Relevance 0.03

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