INT115616

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Context Info
Confidence 0.25
First Reported 2004
Last Reported 2007
Negated 2
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.59
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl5) aging (Ccl5) extracellular region (Ccl5)
cell-cell signaling (Ccl5) cytoplasm (Ccl5)
Anatomy Link Frequency
mononuclear cell 3
neurons 2
neutrophil 1
Ccl5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 2 100.00 Very High Very High Very High
substance P 2 98.56 Very High Very High Very High
Demyelination 47 98.52 Very High Very High Very High
narcan 20 97.74 Very High Very High Very High
Lasting pain 8 96.64 Very High Very High Very High
chemokine 102 95.60 Very High Very High Very High
antagonist 16 89.04 High High
Antinociceptive 1 87.80 High High
Sciatic nerve 15 86.40 High High
Pain 15 84.32 Quite High
Disease Link Frequency Relevance Heat
Demyelinating Disease 48 98.52 Very High Very High Very High
Pain 26 96.64 Very High Very High Very High
Nervous System Injury 28 85.76 High High
Hyperalgesia 21 42.32 Quite Low
Neuropathic Pain 17 25.52 Quite Low
Hypersensitivity 4 22.00 Low Low
Nociception 14 12.40 Low Low
Injury 14 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 11 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Like CCR2, the CCR5 receptor function and its ligand, RANTES, were also strongly upregulated in DRG neurons in response to focal demyelination.
Positive_regulation (upregulated) of RANTES Binding (ligand) of in neurons associated with demyelination
1) Confidence 0.25 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.59 Pain Relevance 0.87
Naloxone induced peripheral blood nonadherent mononuclear cell and neutrophil chemotaxis at nanomolar concentrations and deactivated their migration toward beta-endorphin, angiotensin II, somatostatin, or interleukin-8 but not toward RANTES, vasoactive intestinal peptide, or substance P.
Neg (not) Positive_regulation (deactivated) of RANTES Neg (not) Binding (migration) of in mononuclear cell associated with somatostatin, narcan and substance p
2) Confidence 0.02 Published 2004 Journal Biochemistry Section Abstract Doc Link 14705951 Disease Relevance 0 Pain Relevance 0.58
Naloxone induced peripheral blood nonadherent mononuclear cell and neutrophil chemotaxis at nanomolar concentrations and deactivated their migration toward beta-endorphin, angiotensin II, somatostatin, or interleukin-8 but not toward RANTES, vasoactive intestinal peptide, or substance P.
Neg (not) Positive_regulation (deactivated) of RANTES in neutrophil Neg (not) Binding (migration) of in mononuclear cell associated with somatostatin, narcan and substance p
3) Confidence 0.01 Published 2004 Journal Biochemistry Section Abstract Doc Link 14705951 Disease Relevance 0 Pain Relevance 0.58

General Comments

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