INT115622

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 5.79
Pain Relevance 2.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8)
intracellular (IL8)
Anatomy Link Frequency
neutrophils 6
mononuclear cell 3
cartilage 2
macrophages 1
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 2 100.00 Very High Very High Very High
corticosteroid 8 99.50 Very High Very High Very High
Osteoarthritis 63 98.90 Very High Very High Very High
narcan 20 97.74 Very High Very High Very High
substance P 2 97.68 Very High Very High Very High
Inflammation 118 97.60 Very High Very High Very High
chemokine 102 96.68 Very High Very High Very High
metalloproteinase 9 87.12 High High
antagonist 5 84.24 Quite High
opiate 6 83.44 Quite High
Disease Link Frequency Relevance Heat
Cancer 5 98.96 Very High Very High Very High
Osteoarthritis 66 98.90 Very High Very High Very High
Necrosis 5 98.48 Very High Very High Very High
INFLAMMATION 133 97.60 Very High Very High Very High
Infection 23 95.88 Very High Very High Very High
Pulmonary Disease 108 94.32 High High
Asthma 61 92.68 High High
Fever 20 86.48 High High
Airway Remodeling 2 85.08 High High
Toxicity 4 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, we show that robust neutrophil recruitment requires CXCL8 dimerization, and that the ability of CXCL8 to reversibly exist as monomers and dimers and GAG binding-mediated gradient formation play critical roles in regulating neutrophil recruitment.
Positive_regulation (requires) of CXCL8 Binding (dimerization) of in neutrophil
1) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.26 Pain Relevance 0.12
The only studies on GAG-bound chemokine in which CXCL8 activity was measured with and without adding soluble GAG in cell-based assays were inconclusive and contradictory with one study showing soluble GAG enhances CXCL8 binding and the other showing reduced binding [40], [41].
Positive_regulation (enhances) of CXCL8 Binding (binding) of associated with chemokine
2) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0 Pain Relevance 0.15
In conclusion, OA cartilage was shown to respond to leptin by producing increased amounts of NO, PGE2, IL-6, IL-8, and all those effects can be considered harmful in cartilage metabolism.
Positive_regulation (increased) of IL-8 Neg (NO) Binding (amounts) of in cartilage associated with osteoarthritis
3) Confidence 0.31 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.46 Pain Relevance 0.32
Bronchoalveolar lavage (BAL) fluid following endotoxin instillation shows increased numbers of macrophages and neutrophils along with increased concentrations of interleukin-6 (IL-6), IL-8, IL-1?
Positive_regulation (increased) of IL-8 Binding (concentrations) of in neutrophils
4) Confidence 0.04 Published 2009 Journal J Occup Med Toxicol Section Body Doc Link PMC2701955 Disease Relevance 1.94 Pain Relevance 0.15
Corticosteroids also do not inhibit the increased concentrations of IL-8 and TNF-?
Positive_regulation (increased) of IL-8 Binding (concentrations) of associated with corticosteroid
5) Confidence 0.04 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 1.19 Pain Relevance 0.63
Naloxone induced peripheral blood nonadherent mononuclear cell and neutrophil chemotaxis at nanomolar concentrations and deactivated their migration toward beta-endorphin, angiotensin II, somatostatin, or interleukin-8 but not toward RANTES, vasoactive intestinal peptide, or substance P.
Neg (not) Positive_regulation (deactivated) of interleukin-8 Neg (not) Binding (migration) of in mononuclear cell associated with somatostatin, narcan and substance p
6) Confidence 0.03 Published 2004 Journal Biochemistry Section Abstract Doc Link 14705951 Disease Relevance 0 Pain Relevance 0.58
Bronchoalveolar lavage (BAL) fluid following endotoxin instillation shows increased numbers of macrophages and neutrophils along with increased concentrations of interleukin-6 (IL-6), IL-8, IL-1?
Positive_regulation (increased) of IL-8 in macrophages Binding (concentrations) of in neutrophils
7) Confidence 0.01 Published 2009 Journal J Occup Med Toxicol Section Body Doc Link PMC2701955 Disease Relevance 1.94 Pain Relevance 0.15
Naloxone induced peripheral blood nonadherent mononuclear cell and neutrophil chemotaxis at nanomolar concentrations and deactivated their migration toward beta-endorphin, angiotensin II, somatostatin, or interleukin-8 but not toward RANTES, vasoactive intestinal peptide, or substance P.
Neg (not) Positive_regulation (deactivated) of interleukin-8 in neutrophil Neg (not) Binding (migration) of in mononuclear cell associated with somatostatin, narcan and substance p
8) Confidence 0.01 Published 2004 Journal Biochemistry Section Abstract Doc Link 14705951 Disease Relevance 0 Pain Relevance 0.58

General Comments

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