INT115649

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 95
Total Number 95
Disease Relevance 33.22
Pain Relevance 38.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Camk2a) kinase activity (Camk2a) cytoplasm (Camk2a)
Anatomy Link Frequency
forebrain 13
brain 10
neurons 5
dentate gyrus 3
hypothalamus 3
Camk2a (Mus musculus)
Camk2a - F89G (2)
Pain Link Frequency Relevance Heat
nMDA receptor 437 100.00 Very High Very High Very High
Hippocampus 333 100.00 Very High Very High Very High
Anterior cingulate cortex 890 99.98 Very High Very High Very High
Kinase C 250 99.96 Very High Very High Very High
Hyperalgesia 159 99.84 Very High Very High Very High
Spinal cord 432 99.68 Very High Very High Very High
Locus ceruleus 20 99.68 Very High Very High Very High
long-term potentiation 899 99.66 Very High Very High Very High
depression 416 99.56 Very High Very High Very High
Morphine 365 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 1841 100.00 Very High Very High Very High
Aids-related Complex 2 99.96 Very High Very High Very High
Hyperalgesia 252 99.84 Very High Very High Very High
Ganglion Cysts 109 99.82 Very High Very High Very High
Depression 422 99.56 Very High Very High Very High
Injury 380 99.44 Very High Very High Very High
Neuropathic Pain 269 99.40 Very High Very High Very High
Schizophrenia 236 99.36 Very High Very High Very High
Nociception 226 99.12 Very High Very High Very High
Anaplastic Astrocytoma 7 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that forebrain overexpression of CaMKII did not affect basal nociception and behavioral nociceptive responses to subcutaneous injection of formalin.
Gene_expression (overexpression) of CaMKII in forebrain associated with nociception
1) Confidence 0.78 Published 2006 Journal Mol Pain Section Body Doc Link PMC1513196 Disease Relevance 1.05 Pain Relevance 0.30
Results described above indicate that overexpressing CaMKII in the forebrain causes selective changes in synaptic LTD without causing any obvious anatomical abnormality or change in neuronal excitability.
Gene_expression (overexpressing) of CaMKII in neuronal associated with neuronal excitability
2) Confidence 0.78 Published 2006 Journal Mol Pain Section Body Doc Link PMC1513196 Disease Relevance 0.49 Pain Relevance 0.36
Therefore, over expressed CaMKII activity within neurons may have opposite effects on certain outcomes (either at synaptic or behavioral levels) as compared with NMDA receptors.
Gene_expression (expressed) of CaMKII in neurons associated with nmda receptor
3) Confidence 0.78 Published 2006 Journal Mol Pain Section Body Doc Link PMC1513196 Disease Relevance 1.18 Pain Relevance 0.70
Considering the important roles of CaMKII in neurodevelopment, it is important to confirm that the phenotypic changes found in brain slices and in nociceptive behaviors can be reversed by simply inhibiting the over expression of CaMKII.
Gene_expression (expression) of CaMKII in brain associated with nociception
4) Confidence 0.78 Published 2006 Journal Mol Pain Section Body Doc Link PMC1513196 Disease Relevance 0.82 Pain Relevance 0.45
The rescuing effect of 1NM-PP1 in CaMKII transgenic mice provides strong evidence that the electrophysiological and behavioral changes observed in CaMKII transgenic mice are not due to any developmental changes induced by CaMKII overexpression.
Gene_expression (overexpression) of CaMKII associated with targeted disruption
5) Confidence 0.78 Published 2006 Journal Mol Pain Section Body Doc Link PMC1513196 Disease Relevance 1.16 Pain Relevance 0.32
We then tested if forebrain overexpression of CaMKII affects synaptic LTD in the ACC.
Gene_expression (overexpression) of CaMKII in forebrain associated with anterior cingulate cortex
6) Confidence 0.78 Published 2006 Journal Mol Pain Section Body Doc Link PMC1513196 Disease Relevance 0.45 Pain Relevance 0.40
CaMKII overexpression did not cause changes in the intrinsic neuronal electrophysiological properties of ACC neurons.
Gene_expression (overexpression) of CaMKII associated with anterior cingulate cortex
7) Confidence 0.78 Published 2006 Journal Mol Pain Section Body Doc Link PMC1513196 Disease Relevance 0.55 Pain Relevance 0.35
No CaMKII overexpression was detected in the hindbrain or spinal cord [16].
Gene_expression (overexpression) of CaMKII in spinal cord associated with spinal cord
8) Confidence 0.78 Published 2006 Journal Mol Pain Section Body Doc Link PMC1513196 Disease Relevance 0.77 Pain Relevance 0.19
Double-labeling immunofluorescence studies revealed that in the mouse alpha-CaMKII is expressed in the superficial dorsal horn as well as in a population of small diameter primary afferent neurons.
Gene_expression (expressed) of alpha-CaMKII in afferent neurons associated with dorsal horn
9) Confidence 0.78 Published 2004 Journal Neuroscience Section Abstract Doc Link 15464294 Disease Relevance 0.99 Pain Relevance 0.50
Alpha-CaMKII is expressed postnatally and dramatically increases from day 5 after birth [46,47].
Gene_expression (expressed) of CaMKII
10) Confidence 0.75 Published 2008 Journal Mol Brain Section Body Doc Link PMC2562999 Disease Relevance 0.60 Pain Relevance 0.08
Increased expression of Ca2+/calmodulin-dependent protein kinase II alpha during chronic morphine exposure.
Gene_expression (expression) of Ca2+/calmodulin-dependent protein kinase II alpha associated with morphine
11) Confidence 0.72 Published 2004 Journal Neuroscience Section Title Doc Link 14706789 Disease Relevance 0 Pain Relevance 0.98
For Camk2a, Kcnc4 and Unc5a, the same allele is expressed in all 6 NSC lines.
Gene_expression (expressed) of Camk2a
12) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973945 Disease Relevance 0.22 Pain Relevance 0
The rescuing effect of 1NM-PP1 in CaMKII transgenic mice provides strong evidence that the electrophysiological and behavioral changes observed in CaMKII transgenic mice are not due to any developmental changes induced by CaMKII overexpression.
Gene_expression (transgenic mice) of CaMKII associated with targeted disruption
13) Confidence 0.67 Published 2006 Journal Mol Pain Section Body Doc Link PMC1513196 Disease Relevance 1.21 Pain Relevance 0.39
Why was behavioral sensitization to injury reduced while synaptic depression abolished in the ACC CaMKII transgenic mice?
Gene_expression (transgenic mice) of CaMKII associated with targeted disruption, depression, injury and anterior cingulate cortex
14) Confidence 0.67 Published 2006 Journal Mol Pain Section Body Doc Link PMC1513196 Disease Relevance 1.26 Pain Relevance 0.86
CaMKII overexpression selectively affected the frequency-response relationship of synaptic plasticity in the CA1 region of the hippocampus [16].
Gene_expression (overexpression) of CaMKII in hippocampus associated with hippocampus
15) Confidence 0.67 Published 2006 Journal Mol Pain Section Body Doc Link PMC1513196 Disease Relevance 0.62 Pain Relevance 0.32
CaMKII-F89G transgenic mice may serve as an excellent model for investigating the role of CaMKII in forebrain plasticity.
Gene_expression (transgenic mice) of CaMKII (F89G) in forebrain associated with targeted disruption
16) Confidence 0.67 Published 2006 Journal Mol Pain Section Body Doc Link PMC1513196 Disease Relevance 0.61 Pain Relevance 0.37
Transgenic mice that overexpress a calcium independent form of CaMKII in forebrain areas demonstrated a shift of frequency-dependent responses to repetitive stimulation [4].
Gene_expression (overexpress) of CaMKII in forebrain associated with targeted disruption
17) Confidence 0.67 Published 2006 Journal Mol Pain Section Body Doc Link PMC1513196 Disease Relevance 0.17 Pain Relevance 0.16
CaMKII or CaMKIV were found.
Gene_expression (found) of CaMKII
18) Confidence 0.67 Published 2006 Journal Mol Pain Section Body Doc Link PMC1513196 Disease Relevance 0.89 Pain Relevance 0.17
CaMKII-F89G transgenic mice, we found that ?
Gene_expression (found) of CaMKII (F89G) associated with targeted disruption
19) Confidence 0.67 Published 2006 Journal Mol Pain Section Body Doc Link PMC1513196 Disease Relevance 0.63 Pain Relevance 0.37
-CaMKII has 10-fold higher affinity for Ca2+/CaM than ?
Gene_expression (has) of CaMKII
20) Confidence 0.66 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0

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