INT115656

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 10
Disease Relevance 5.23
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) signal transduction (Glp1r) extracellular region (Ins1)
plasma membrane (Glp1r) carbohydrate metabolic process (Ins1) cytoplasm (Ins1)
Anatomy Link Frequency
lung 6
plasma 2
sensory nerves 2
neural 2
brain 1
Glp1r (Mus musculus)
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 6 99.08 Very High Very High Very High
agonist 33 94.72 High High
vagus nerve 5 86.72 High High
tolerance 57 76.64 Quite High
Neuropeptide 12 48.16 Quite Low
Inflammation 40 5.00 Very Low Very Low Very Low
pruritus 16 5.00 Very Low Very Low Very Low
headache 16 5.00 Very Low Very Low Very Low
substance P 8 5.00 Very Low Very Low Very Low
cva 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Weight Loss 16 97.08 Very High Very High Very High
Diabetes Mellitus 770 96.72 Very High Very High Very High
Obesity 80 87.12 High High
Hypoglycemia 232 82.08 Quite High
Impaired Glucose Tolerance 49 76.64 Quite High
Insulin Resistance 128 76.12 Quite High
Stress 9 72.20 Quite High
Cardiovascular Disease 24 63.84 Quite High
Congenital Anomalies 32 52.08 Quite High
Overweight 16 49.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded that GLP-1-induced insulin secretion at a low dose in mice is dependent on intact sensory nerves and therefore indirectly mediated and that this distinguishes GLP-1 from other examined insulin secretagogues.
GLP-1-induced Spec (examined) Positive_regulation (induced) of Localization (secretion) of insulin in sensory nerves
1) Confidence 0.42 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14707011 Disease Relevance 0 Pain Relevance 0.43
GLP-1 is secreted by enteroendocrine L cells and enhances glucose-stimulated insulin secretion (9).
GLP-1 Positive_regulation (enhances) of Localization (secretion) of insulin
2) Confidence 0.14 Published 2008 Journal Diabetes Section Body Doc Link PMC2551668 Disease Relevance 0.09 Pain Relevance 0.16
GLP-1 increases insulin secretion, decreases glucagon, slows gastric emptying, and results in satiety and weight loss.
GLP-1 Positive_regulation (increases) of Localization (secretion) of insulin associated with weight loss
3) Confidence 0.04 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941781 Disease Relevance 1.13 Pain Relevance 0.04
In order for GLP-1 to enhance insulin secretion, the plasma glucose concentration must be higher than 90 mg/dL.95–99 In contrast, sulfonylureas stimulate insulin secretion irrespective of the ambient glucose concentration.
GLP-1 Positive_regulation (enhance) of Localization (secretion) of insulin in plasma
4) Confidence 0.04 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941781 Disease Relevance 0.55 Pain Relevance 0.04
Circulating concentrations of GLP-1 rise rapidly within minutes after food ingestion indicating that neural signals, initiated by food entry in the proximal gastrointestinal tract, stimulate GLP-1 secretion via the L-cells.87 Acutely, GLP-1 promotes normal glucose homeostasis by augmenting insulin secretion, inhibiting glucagon secretion and delaying gastric emptying.
GLP-1 Positive_regulation (augmenting) of Localization (secretion) of insulin in neural
5) Confidence 0.04 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941781 Disease Relevance 0.39 Pain Relevance 0.03
GLP-1 receptors have been identified in the pancreas (beta and alpha cells), kidney, heart, stomach, lung, and brain.8,9 GLP-1 enhances glucose-dependent insulin secretion, causes glucose-dependent suppression of elevated glucagon secretion, slows gastric emptying, and reduces food intake.
GLP-1 Positive_regulation (enhances) of Localization (secretion) of insulin in lung
6) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941781 Disease Relevance 0.61 Pain Relevance 0.04
GLP-1 receptors have been identified in the pancreas (beta and alpha cells), kidney, heart, stomach, lung, and brain.8,9 GLP-1 enhances glucose-dependent insulin secretion, causes glucose-dependent suppression of elevated glucagon secretion, slows gastric emptying, and reduces food intake.
GLP-1 Positive_regulation (enhances) of in kidney Localization (secretion) of insulin in lung
7) Confidence 0.01 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941781 Disease Relevance 0.61 Pain Relevance 0.04
GLP-1 receptors have been identified in the pancreas (beta and alpha cells), kidney, heart, stomach, lung, and brain.8,9 GLP-1 enhances glucose-dependent insulin secretion, causes glucose-dependent suppression of elevated glucagon secretion, slows gastric emptying, and reduces food intake.
GLP-1 Positive_regulation (enhances) of in brain Localization (secretion) of insulin in lung
8) Confidence 0.01 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941781 Disease Relevance 0.61 Pain Relevance 0.04
GLP-1 receptors have been identified in the pancreas (beta and alpha cells), kidney, heart, stomach, lung, and brain.8,9 GLP-1 enhances glucose-dependent insulin secretion, causes glucose-dependent suppression of elevated glucagon secretion, slows gastric emptying, and reduces food intake.
GLP-1 Positive_regulation (enhances) of in stomach Localization (secretion) of insulin in lung
9) Confidence 0.01 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941781 Disease Relevance 0.61 Pain Relevance 0.04
GLP-1 receptors have been identified in the pancreas (beta and alpha cells), kidney, heart, stomach, lung, and brain.8,9 GLP-1 enhances glucose-dependent insulin secretion, causes glucose-dependent suppression of elevated glucagon secretion, slows gastric emptying, and reduces food intake.
GLP-1 Positive_regulation (enhances) of in heart Localization (secretion) of insulin in lung
10) Confidence 0.01 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941781 Disease Relevance 0.61 Pain Relevance 0.04

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