INT115659

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 29
Total Number 30
Disease Relevance 13.59
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCB6) mitochondrion (ABCB6) Golgi apparatus (ABCB6)
ATPase activity (ABCB6) plasma membrane (ABCB6) transmembrane transport (ABCB6)
Anatomy Link Frequency
livers 1
pancreas 1
arm 1
Rim 1
vesicles 1
ABCB6 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 1 98.56 Very High Very High Very High
Bile 54 97.80 Very High Very High Very High
methotrexate 11 97.60 Very High Very High Very High
Chronic pancreatitis 2 97.60 Very High Very High Very High
adenocard 4 95.08 Very High Very High Very High
Bioavailability 64 94.28 High High
fluoxetine 1 91.72 High High
abdominal pain 12 91.56 High High
cINOD 8 84.32 Quite High
Pain 6 83.96 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 192 99.96 Very High Very High Very High
Cancer 192 99.86 Very High Very High Very High
Exanthema 96 99.80 Very High Very High Very High
Dizziness 24 99.58 Very High Very High Very High
Toxicity 61 99.44 Very High Very High Very High
Vomiting 60 99.26 Very High Very High Very High
Targeted Disruption 58 98.80 Very High Very High Very High
Syndrome 43 98.20 Very High Very High Very High
Pancreatitis 6 97.60 Very High Very High Very High
Anaemia 12 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND AND AIMS: The expression of the ABC-transporters MDR-1, MRP1, and MRP-2 was investigated in healthy pancreas and in chronic pancreatitis tissue samples in rats and humans to evaluate their possible involvement in a multidrug resistance of the pancreas with consequences for the pharmacologic treatment of pancreatic diseases.
Gene_expression (expression) of ABC in pancreas associated with pancreatitis and chronic pancreatitis
1) Confidence 0.75 Published 2004 Journal Pancreas Section Abstract Doc Link 14707729 Disease Relevance 0.26 Pain Relevance 0.17
The ABC HSR is an idiosyncratic multiorgan clinical syndrome usually characterized by a sign or symptom in 2 or more of the following groups: (i) fever; (ii) rash; (iii) gastrointestinal: nausea, vomiting, diarrhea or abdominal pain; (iv) constitutional: generalized malaise, fatigue or achiness; and (v) respiratory: dyspnea, cough, and/or pharyngitis.
Gene_expression (The) of ABC in respiratory associated with abdominal pain, diarrhoea, syndrome, vomiting, fever, exanthema, pharyngitis, cough, fatigue and dyspnea
2) Confidence 0.29 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 1.61 Pain Relevance 0.09
Similarly, the incidence of the ABC HSR decreased from 6.2% to 0.5% in a UK cohort of 185 patients treated with ABC using HLA screening.31
Gene_expression (incidence) of ABC
3) Confidence 0.29 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.74 Pain Relevance 0
There are no established interventions that will preempt the development of the ABC HSR.
Gene_expression (development) of ABC
4) Confidence 0.29 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.45 Pain Relevance 0
When it is not clear if clinical symptoms are due to the ABC HSR, the drug may be continued under close clinical surveillance.
Gene_expression (due) of ABC
5) Confidence 0.29 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.60 Pain Relevance 0
The present study quantitatively evaluated the possible role of the transporters in such drug-drug interactions using human kidney slices and membrane vesicles expressing human ATP-binding cassette (ABC) transporters.
Gene_expression (expressing) of ABC in vesicles
6) Confidence 0.29 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17578901 Disease Relevance 0.16 Pain Relevance 0.52
The presence of P-glycoprotein (P-gp), MRP4 and BCRP, ABC-transporters located in the BBB, has been shown on mRNA level, by immunostaining, and western blot.
Gene_expression (presence) of ABC
7) Confidence 0.26 Published 2005 Journal Brain Res. Section Abstract Doc Link 16289483 Disease Relevance 0 Pain Relevance 0.13
ABC/3TC as separate agents combined with a PI or NNRTI
Gene_expression (/) of ABC
8) Confidence 0.25 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.21 Pain Relevance 0
A similar ABC exposure and antiviral effect was observed in all three regimens.
Gene_expression (exposure) of ABC
9) Confidence 0.25 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.21 Pain Relevance 0
Reasons for discontinuation of drug in the ABC arm included nausea (2%), dizziness (1%), rash (3%) and suspected ABC HSR (8%); in the AZT arm, nausea, dizziness, rash (3% each) and anemia (4%) were the most common reasons for drug discontinuation.
Gene_expression (suspected) of ABC in arm associated with exanthema, anaemia, dizziness and vomiting
10) Confidence 0.25 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 1.04 Pain Relevance 0
Patients randomized to receive prednisone 40 mg/day for the first 2 weeks when initiating ABC therapy in combination with nevirapine (NVP) and ZDV/3TC experienced a slightly higher incidence of hypersensitivity than those patients who did not receive prednisone (17% versus 10%, respectively).34
Gene_expression (therapy) of ABC associated with hypersensitivity
11) Confidence 0.25 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.46 Pain Relevance 0
The abacavir-selected mutations K65R, L74V and Y115F each individually confer about three-to fourfold resistance to ABC, but in combinations of 2 or 3, they confer up to 8- to 10-fold resistance.67
Gene_expression (fourfold) of ABC
12) Confidence 0.25 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.20 Pain Relevance 0
Lactic acidosis results from the inhibition of mitochondrial DNA synthesis by the nucleoside analogs, resulting in anaerobic glycolysis and intracelluar accumulation of lactate. 3TC has greater affinity for mitochondrial DNA than does ABC.56,57 In vitro data have shown that neither 3TC nor ABC is associated with hepatic cytotoxicity or depletion of mitochondrial DNA.58 Furthermore, in a cohort study evaluating the risk factors for hyperlactatemia and lactic acidosis, ABC/3TC was associated with the lowest relative risk amongst NRTI pairs in the trial.59 The combination of ABC + 3TC also has been shown to have minimal or no effects on in terms of lipoatrophy as well as favorable lipid insulin and other metabolic effects.60–62 Replacing stavudine with abacavir or zidovudine has been shown to improve stavudine-induced lipoatrophy.63

Resistance

Neg (neither) Gene_expression (3TC) of ABC associated with lactic acidosis and lipodystrophy
13) Confidence 0.25 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.82 Pain Relevance 0
In this analysis there were few MI events overall and no excess risk of MI with ABC therapy.37
Gene_expression (therapy.37) of ABC
14) Confidence 0.25 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.77 Pain Relevance 0.04
However, the potential severity of ABC hypersensitivity calls for prudence.
Gene_expression (severity) of ABC associated with hypersensitivity
15) Confidence 0.25 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.57 Pain Relevance 0
Structural model and overall architecture of ABC transporter (CpABC)
Gene_expression (model) of CpABC
16) Confidence 0.18 Published 2010 Journal Bioinformation Section Body Doc Link PMC2957761 Disease Relevance 0 Pain Relevance 0.09
Since ABC transporters can be coexpressed in some types of cancer cells, the development of chemosensitizers against MRP and/or BCRP as well as Pgp has been highly demanding.
Gene_expression (coexpressed) of ABC associated with cancer
17) Confidence 0.10 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1277830 Disease Relevance 0.29 Pain Relevance 0
Deletion of the ABC subfamily A (ABC1), member four (ABCA4, alternatively ABCR) gene [43,44], which encodes for the rod OS protein Rim (RmP) [45,46], functions in the transmembrane transport of vitamin A derivatives to the RPE and accounts for 60% of STGD cases [47].
Gene_expression (Deletion) of ABC in Rim associated with disease
18) Confidence 0.09 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 0.84 Pain Relevance 0.09
Functions of ABC transporters
Gene_expression (transporters) of ABC
19) Confidence 0.08 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1277830 Disease Relevance 0.93 Pain Relevance 0.03
One strategy for reversal of the resistance of tumor cells expressing ABC transporters is combined use of anticancer drugs with chemosensitizers.
Gene_expression (expressing) of ABC associated with cancer
20) Confidence 0.07 Published 2005 Journal Cancer Cell Int Section Abstract Doc Link PMC1277830 Disease Relevance 0.10 Pain Relevance 0.05

General Comments

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