INT115660

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Context Info
Confidence 0.17
First Reported 2004
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.36
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCC1) small molecule metabolic process (ABCC1) Golgi apparatus (ABCC1)
nucleolus (ABCC1) ATPase activity (ABCC1) plasma membrane (ABCC1)
Anatomy Link Frequency
liver 2
pancreas 2
ABCC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 2 100.00 Very High Very High Very High
Morphine 3 50.00 Quite Low
Bile 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 3 100.00 Very High Very High Very High
Gallstones 2 92.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND AND AIMS: The expression of the ABC-transporters MDR-1, MRP1, and MRP-2 was investigated in healthy pancreas and in chronic pancreatitis tissue samples in rats and humans to evaluate their possible involvement in a multidrug resistance of the pancreas with consequences for the pharmacologic treatment of pancreatic diseases.
Spec (possible) Regulation (evaluate) of Gene_expression (expression) of MRP1 in pancreas associated with pancreatitis and chronic pancreatitis
1) Confidence 0.17 Published 2004 Journal Pancreas Section Abstract Doc Link 14707729 Disease Relevance 0.27 Pain Relevance 0.17
Changes in the mRNA expression of multidrug resistance-associated protein (MRP)2, MRP3 and UDP-glucuronosyltransferase (UGT)2B1 in the liver were estimated using RT-PCR.
Regulation (Changes) of Gene_expression (expression) of multidrug resistance-associated protein in liver
2) Confidence 0.01 Published 2009 Journal J. Pharm. Pharmacol. Section Body Doc Link 19703370 Disease Relevance 0.09 Pain Relevance 0

General Comments

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