INT115661

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Context Info
Confidence 0.34
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.40
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MRPL1) structural constituent of ribosome (MRPL1) ribosome (MRPL1)
RNA binding (MRPL1) intracellular (MRPL1) translation (MRPL1)
Anatomy Link Frequency
pancreas 2
MRPL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 6 50.00 Quite Low
cINOD 4 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 2 90.04 High High
Pancreatitis 9 87.84 High High
Carcinoma 2 50.00 Quite Low
Apoptosis 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observed effect is due to quenching of MDR-1 and MRP-1 genes expression, which results in blocking of efflux of DOX outside the cells, which in turn correlates with enhanced apoptotic effects.
Gene_expression (expression) of MRP-1
1) Confidence 0.34 Published 2010 Journal Med. Sci. Monit. Section Body Doc Link 20037485 Disease Relevance 0.06 Pain Relevance 0
MATERIAL/METHODS: Cytotoxic activity of the drugs was defined with MTT test, apoptosis was detected with TUNEL test, DOX transmembrane efflux was measured fluorometrically, expression of MDR-1 and MRP-1 was determined with quantitative real time - PCR (QRT-PCR).
Gene_expression (expression) of MRP-1
2) Confidence 0.34 Published 2010 Journal Med. Sci. Monit. Section Body Doc Link 20037485 Disease Relevance 0.09 Pain Relevance 0
The expression of MDR-1, MRP-1, MRP-2, and furthermore, LRP and PAP was investigated by RT-PCR, Real Time TaqManPCR, and immunohistochemistry.
Spec (investigated) Gene_expression (expression) of MRP-1
3) Confidence 0.22 Published 2004 Journal Pancreas Section Body Doc Link 14707729 Disease Relevance 0.09 Pain Relevance 0
RESULTS: In rat pancreas, MDR-1 (P-gp) and MRP-1 but in human pancreas MDR-1 (P-gp), MRP-1 and MRP-2 were found to be expressed.
Gene_expression (expressed) of MRP-1 in pancreas
4) Confidence 0.22 Published 2004 Journal Pancreas Section Body Doc Link 14707729 Disease Relevance 0.08 Pain Relevance 0
RESULTS: In rat pancreas, MDR-1 (P-gp) and MRP-1 but in human pancreas MDR-1 (P-gp), MRP-1 and MRP-2 were found to be expressed.
Gene_expression (expressed) of MRP-1 in pancreas
5) Confidence 0.19 Published 2004 Journal Pancreas Section Body Doc Link 14707729 Disease Relevance 0.08 Pain Relevance 0

General Comments

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