INT115662

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Context Info
Confidence 0.60
First Reported 2004
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.10
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCC2) ATPase activity (ABCC2) plasma membrane (ABCC2)
transmembrane transport (ABCC2)
Anatomy Link Frequency
pancreas 2
lung 2
ABCC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 2 100.00 Very High Very High Very High
dexamethasone 2 97.84 Very High Very High Very High
cINOD 2 87.20 High High
Inflammation 2 26.40 Quite Low
Disease Link Frequency Relevance Heat
Pancreatitis 3 100.00 Very High Very High Very High
Lung Cancer 6 96.58 Very High Very High Very High
Cancer 2 91.56 High High
INFLAMMATION 4 87.00 High High
Asthma 2 84.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differential regulation of the human MRP2 and MRP3 gene expression by glucocorticoids.
Regulation (regulation) of Gene_expression (expression) of MRP2
1) Confidence 0.60 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Title Doc Link 15979871 Disease Relevance 0.40 Pain Relevance 0.12
A549 cells (non-small-cell lung cancer cell line) were challenged with glucocorticoids (dexamethasone, hydrocortisone and prednisone) at physiologically and therapeutically relevant concentrations for 24h and changes in MRP2 and MRP3 expression were followed on four levels: promoter regulation (luciferase reporter constructs), mRNA level (semi-quantitative real-time PCR), protein level (Western blotting) and activity (drug resistance and cellular transport of the model substrate calcein).
Regulation (changes) of Gene_expression (expression) of MRP2 in lung associated with lung cancer and dexamethasone
2) Confidence 0.27 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15979871 Disease Relevance 0.43 Pain Relevance 0.13
BACKGROUND AND AIMS: The expression of the ABC-transporters MDR-1, MRP1, and MRP-2 was investigated in healthy pancreas and in chronic pancreatitis tissue samples in rats and humans to evaluate their possible involvement in a multidrug resistance of the pancreas with consequences for the pharmacologic treatment of pancreatic diseases.
Spec (possible) Regulation (evaluate) of Gene_expression (expression) of MRP-2 in pancreas associated with pancreatitis and chronic pancreatitis
3) Confidence 0.19 Published 2004 Journal Pancreas Section Abstract Doc Link 14707729 Disease Relevance 0.27 Pain Relevance 0.17

General Comments

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