INT115664

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.54
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCB1) ATPase activity (ABCB1) plasma membrane (ABCB1)
transmembrane transport (ABCB1)
Anatomy Link Frequency
placentas 2
ABCB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 2 50.00 Quite Low
cINOD 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
epidural 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 99.84 Very High Very High Very High
Infection 1 96.18 Very High Very High Very High
Pancreatitis 3 75.84 Quite High
Reprotox - General 1 2 69.28 Quite High
Carcinoma 1 50.00 Quite Low
Hypertension 1 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic pancreatitis lead to an increased transcription of mRNA of MDR-1 (rat and human) and much lower, MRP-2 (human).
Positive_regulation (increased) of Transcription (transcription) of MDR-1
1) Confidence 0.37 Published 2004 Journal Pancreas Section Body Doc Link 14707729 Disease Relevance 0.08 Pain Relevance 0
HIV infection itself may play a role as suggested in a study by our group who compared 35 full-term placentas from uninfected women and 24 from HIV-1 infected women and showed a significant 3.3-fold mean increase in MDR1 placental transcription in HIV-infected women.
Positive_regulation (increase) of Transcription (transcription) of MDR1 in placentas associated with acquired immune deficiency syndrome or hiv infection and infection
2) Confidence 0.31 Published 2009 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2778444 Disease Relevance 0.39 Pain Relevance 0
The QRT - PCR analysis has shown that, when used simultaneously, DOX 1 microM and SUL 50 microM results in decreased mRNA level for MDR-1 and MRP-1.
Positive_regulation (results) of Transcription (level) of MDR-1
3) Confidence 0.31 Published 2010 Journal Med. Sci. Monit. Section Body Doc Link 20037485 Disease Relevance 0.07 Pain Relevance 0

General Comments

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