INT115665

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Context Info
Confidence 0.71
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 3.69
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCB1) ATPase activity (ABCB1) plasma membrane (ABCB1)
transmembrane transport (ABCB1)
Anatomy Link Frequency
livers 3
placentas 1
intestine 1
ABCB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 25 100.00 Very High Very High Very High
qutenza 7 89.68 High High
Bioavailability 3 71.56 Quite High
Chronic pancreatitis 2 50.00 Quite Low
Bile 4 25.00 Low Low
cINOD 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
epidural 1 5.00 Very Low Very Low Very Low
IPN 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Biliary Liver Cirrhosis 24 100.00 Very High Very High Very High
Overdose 9 100.00 Very High Very High Very High
Breast Cancer 4 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 99.84 Very High Very High Very High
Infection 1 95.94 Very High Very High Very High
Toxicity 5 88.44 High High
Disease 4 77.36 Quite High
Pancreatitis 3 75.44 Quite High
Acute Liver Failure 3 75.00 Quite High
Reprotox - General 1 3 68.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One of the innovative approaches to addressing MDR is to inhibit MDR1 mRNA expression by RNA interference (RNAi).
Transcription (expression) of MDR1
1) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0.55 Pain Relevance 0
The present study was conducted to investigate the expression of hepatobiliary efflux transporters in livers from patients after toxic acetaminophen (APAP) ingestion, with livers from patients with primary biliary cirrhosis (PBC) serving as positive controls. mRNA and protein expression of multidrug resistance-associated protein (MRP) 1-6, multidrug resistance protein (MDR) 1-3/P-glycoprotein (P-gp), and breast cancer resistance protein (BCRP) in normal (n = 6), APAP overdose (n = 5), and PBC (n = 6) human liver samples were determined by branched DNA and Western blot analysis, respectively.
Transcription (determined) of P-gp in livers associated with biliary liver cirrhosis, paracetamol, breast cancer and overdose
2) Confidence 0.67 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 0.90 Pain Relevance 0.44
The present study was conducted to investigate the expression of hepatobiliary efflux transporters in livers from patients after toxic acetaminophen (APAP) ingestion, with livers from patients with primary biliary cirrhosis (PBC) serving as positive controls. mRNA and protein expression of multidrug resistance-associated protein (MRP) 1-6, multidrug resistance protein (MDR) 1-3/P-glycoprotein (P-gp), and breast cancer resistance protein (BCRP) in normal (n = 6), APAP overdose (n = 5), and PBC (n = 6) human liver samples were determined by branched DNA and Western blot analysis, respectively.
Transcription (expression) of P-glycoprotein in livers associated with biliary liver cirrhosis, paracetamol, breast cancer and overdose
3) Confidence 0.67 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 0.80 Pain Relevance 0.43
The present study was conducted to investigate the expression of hepatobiliary efflux transporters in livers from patients after toxic acetaminophen (APAP) ingestion, with livers from patients with primary biliary cirrhosis (PBC) serving as positive controls. mRNA and protein expression of multidrug resistance-associated protein (MRP) 1-6, multidrug resistance protein (MDR) 1-3/P-glycoprotein (P-gp), and breast cancer resistance protein (BCRP) in normal (n = 6), APAP overdose (n = 5), and PBC (n = 6) human liver samples were determined by branched DNA and Western blot analysis, respectively.
Transcription (determined) of P-glycoprotein in livers associated with biliary liver cirrhosis, paracetamol, breast cancer and overdose
4) Confidence 0.67 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 0.90 Pain Relevance 0.44
The expression levels of mRNAs of efflux transporters analyzed by real-time RT-PCR indicated that mRNA expression levels of MDR1, MRP2, and BCRP in monkey intestine were significantly higher than those in human intestine.
Transcription (expression) of MDR1 in intestine
5) Confidence 0.60 Published 2008 Journal Mol. Pharm. Section Abstract Doc Link 18247527 Disease Relevance 0 Pain Relevance 0.38
Thus, the present study provides further evidence that repeated exposure to dietary ingredients can cause drug-food interactions by affecting the function and mRNA expression of intestinal transporters such as P-glycoprotein.
Transcription (expression) of P-glycoprotein
6) Confidence 0.52 Published 2010 Journal Biol. Pharm. Bull. Section Abstract Doc Link 20118549 Disease Relevance 0 Pain Relevance 0.23
HIV infection itself may play a role as suggested in a study by our group who compared 35 full-term placentas from uninfected women and 24 from HIV-1 infected women and showed a significant 3.3-fold mean increase in MDR1 placental transcription in HIV-infected women.
Transcription (transcription) of MDR1 in placentas associated with acquired immune deficiency syndrome or hiv infection and infection
7) Confidence 0.48 Published 2009 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2778444 Disease Relevance 0.39 Pain Relevance 0
The QRT - PCR analysis has shown that, when used simultaneously, DOX 1 microM and SUL 50 microM results in decreased mRNA level for MDR-1 and MRP-1.
Transcription (level) of MDR-1
8) Confidence 0.47 Published 2010 Journal Med. Sci. Monit. Section Body Doc Link 20037485 Disease Relevance 0.07 Pain Relevance 0
Chronic pancreatitis lead to an increased transcription of mRNA of MDR-1 (rat and human) and much lower, MRP-2 (human).
Transcription (transcription) of MDR-1
9) Confidence 0.38 Published 2004 Journal Pancreas Section Body Doc Link 14707729 Disease Relevance 0.08 Pain Relevance 0

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