INT11567

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Context Info
Confidence 0.48
First Reported 1984
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 7.69
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Alb) extracellular space (Alb) extracellular region (Alb)
enzyme binding (Alb) DNA binding (Alb) protein complex (Alb)
Anatomy Link Frequency
hepatocytes 4
Heart 4
blood 2
kidney 2
Urine 2
Alb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 5 99.74 Very High Very High Very High
cytokine 3 99.00 Very High Very High Very High
headache 6 98.98 Very High Very High Very High
Clonidine 7 97.72 Very High Very High Very High
Pain 4 95.60 Very High Very High Very High
depression 2 93.28 High High
lidocaine 1 79.20 Quite High
Inflammatory marker 3 75.28 Quite High
Paracetamol 4 71.60 Quite High
cINOD 2 65.28 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 93 99.90 Very High Very High Very High
Diabetes Mellitus 169 99.84 Very High Very High Very High
Disorder Of Lipid Metabolism 3 99.50 Very High Very High Very High
Hypertension 81 99.32 Very High Very High Very High
Weight Loss 28 98.46 Very High Very High Very High
Renal Failure 2 97.72 Very High Very High Very High
Renal Disease 19 97.44 Very High Very High Very High
Cv Unclassified Under Development 3 96.00 Very High Very High Very High
Pain 4 95.60 Very High Very High Very High
Albuminuria 12 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The production of proteins by hepatocyte spheroids could be regulated in vitro by IL-6: the secretion of alpha 2-macroglobulin was increased and the secretion of albumin was decreased in the presence of this cytokine.
Negative_regulation (decreased) of Localization (secretion) of albumin in hepatocyte associated with cytokine
1) Confidence 0.48 Published 1992 Journal Exp. Cell Res. Section Abstract Doc Link 1572400 Disease Relevance 0 Pain Relevance 0.13
Significant decreases in urea and albumin secretions were detected after treatments with 32 nM aflatoxin B(1) and 1 mM doses of cadmium and the alkylating agents N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and methyl methane sulfonate (MMS).
Negative_regulation (decreases) of Localization (secretions) of albumin
2) Confidence 0.47 Published 2005 Journal Toxicol. Sci. Section Abstract Doc Link 15772367 Disease Relevance 0.25 Pain Relevance 0.18
Acute reduction of arterial blood pressure reduces urinary albumin excretion in type 1 (insulin-dependent) diabetic patients with incipient nephropathy.
Negative_regulation (reduces) of Localization (excretion) of albumin in blood associated with diabetes mellitus and renal disease
3) Confidence 0.42 Published 1986 Journal Diabetologia Section Title Doc Link 3710012 Disease Relevance 0.47 Pain Relevance 0.27
While glomerular filtration rate and urinary albumin excretion rate remained unchanged in both control groups after clonidine injection, glomerular filtration rate diminished from 78 to 71 ml/min per 1.73 m2 (p les than 0.01), and urinary albumin excretion declined from 1707 to 938 micrograms/min (p less than 0.01) in the patients with diabetic nephropathy.
Negative_regulation (declined) of Localization (excretion) of albumin associated with renal disease and clonidine
4) Confidence 0.41 Published 1984 Journal Diabetologia Section Abstract Doc Link 6442240 Disease Relevance 0.79 Pain Relevance 0.26
As shown in Figure 1, CaO2 progressively decreased, as did Hct values, during stepwise isovolemic hemodilution in both albumin and Oxycyte® treated groups.
Negative_regulation (decreased) of Localization (hemodilution) of albumin
5) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291566 Disease Relevance 0 Pain Relevance 0
Urine albumin excretion as measured by the urinary albumin creatinine ratio decreased significantly in both groups (112.0+/-60.9 to 95.3+/-64.9 mg/g and 108.5+/-51.0 to 96.4+/-53.5 mg/g in the delapril and manidipine group respectively, p < 0.05, by paired t-test).
Negative_regulation (decreased) of Localization (excretion) of albumin in Urine
6) Confidence 0.34 Published 2001 Journal J Med Assoc Thai Section Abstract Doc Link 11336083 Disease Relevance 0.25 Pain Relevance 0.04
Our results show that MMF could decrease urinary albumin excretion, which mechanism may be at least partly correlated with upregulated expression of nephrin and podocin in the glomeruli of diabetic rat.
Negative_regulation (decrease) of Localization (excretion) of albumin associated with diabetes mellitus
7) Confidence 0.32 Published 2008 Journal Cytokine Section Abstract Doc Link 18725182 Disease Relevance 1.02 Pain Relevance 0.12
In contrast to this finding and closer to our own results, modest weight reduction in the intensive lifestyle group of the Diabetes Prevention Program did not reduce albumin excretion significantly (39).


Neg (not) Negative_regulation (reduce) of Localization (excretion) of albumin associated with weight loss and diabetes mellitus
8) Confidence 0.29 Published 2010 Journal European Journal of Endocrinology Section Body Doc Link PMC2950661 Disease Relevance 1.25 Pain Relevance 0.04
In contrast, previous reports on 2D co-cultures of rLSECs and hepatocytes, show that albumin secretion decreased as a function of time [25].
Negative_regulation (decreased) of Localization (secretion) of albumin in hepatocytes
9) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980491 Disease Relevance 0.15 Pain Relevance 0
Heart rate, weight, BMI, waist circumference, total cholesterol, renin and 24 h urinary albumin excretion significantly decreased in both groups after 16 weeks.
Negative_regulation (decreased) of Localization (excretion) of albumin in Heart associated with disorder of lipid metabolism
10) Confidence 0.20 Published 2005 Journal J Hum Hypertens Section Abstract Doc Link 15905884 Disease Relevance 0.77 Pain Relevance 0.18
Reductions in both albumin and haemoglobin excretion were observed in 11 children 54 days after praziquantel treatment.
Negative_regulation (Reductions) of Localization (excretion) of albumin
11) Confidence 0.16 Published 2005 Journal J. Helminthol. Section Abstract Doc Link 16153313 Disease Relevance 0.53 Pain Relevance 0.09
This is in agreement with other studies which have demonstrated reduced urinary albumin excretion and renoprotection by thiazolidinediones [34–36].
Negative_regulation (reduced) of Localization (excretion) of albumin
12) Confidence 0.12 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696219 Disease Relevance 0.44 Pain Relevance 0
RESULTS: An overall clinically significant reduction of 24.3% (geometric mean) (95% confidence interval, 4.1 to 45.0) in the 24-hour urinary albumin excretion rate was observed (P = .014).
Negative_regulation (reduction) of Localization (excretion) of albumin
13) Confidence 0.09 Published 2006 Journal Clin. Pharmacol. Ther. Section Body Doc Link 16952491 Disease Relevance 0.07 Pain Relevance 0
Treatment with vitamins C and E was also shown to decrease urinary albumin excretion, glomerular basement membrane thickness, and kidney weight in STZ diabetic rats [43].
Negative_regulation (decrease) of Localization (excretion) of albumin in kidney associated with diabetes mellitus
14) Confidence 0.07 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1131912 Disease Relevance 0.53 Pain Relevance 0
Clinical trials have demonstrated its efficacy at a dose range of 2 to 32 mg once daily in hypertension of all grades, heart failure, in reducing urinary albumin excretion in diabetes mellitus and in coexisting hypertension and renal failure.
Negative_regulation (reducing) of Localization (excretion) of albumin in heart associated with renal failure, diabetes mellitus, hypertension and myocardial infarction
15) Confidence 0.05 Published 2004 Journal Cardiovasc Drug Rev Section Abstract Doc Link 15592574 Disease Relevance 0.60 Pain Relevance 0.10
The angiotensin II receptor antagonist telmisartan reduces urinary albumin excretion in patients with isolated systolic hypertension: results of a randomized, double-blind, placebo-controlled trial.
Negative_regulation (reduces) of Localization (excretion) of albumin associated with antagonist, hypertension and headache
16) Confidence 0.05 Published 2005 Journal J. Hypertens. Section Title Doc Link 16208149 Disease Relevance 0.10 Pain Relevance 0.15
Significant reductions in albumin secretion (16% relative reduction; p = 0.003) and progression to overt microalbuminuria were observed with carvedilol compared with metoprolol (p = 0.04).
Negative_regulation (reductions) of Localization (secretion) of albumin
17) Confidence 0.01 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663448 Disease Relevance 0.45 Pain Relevance 0

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