INT11568

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Context Info
Confidence 0.73
First Reported 1992
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 14
Total Number 17
Disease Relevance 1.51
Pain Relevance 7.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ADORA2A) enzyme binding (ADORA2A) cell-cell signaling (ADORA2A)
signal transducer activity (ADORA2A)
Anatomy Link Frequency
striatum 3
NG108-15 2
nucleus accumbens 1
neurons 1
putamen 1
ADORA2A (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 993 100.00 Very High Very High Very High
agonist 215 100.00 Very High Very High Very High
Neuropeptide 4 99.74 Very High Very High Very High
substance P 6 98.36 Very High Very High Very High
antagonist 290 97.44 Very High Very High Very High
Nucleus accumbens 12 97.40 Very High Very High Very High
Dopamine 22 97.28 Very High Very High Very High
Pain 1 92.60 High High
opiate 2 85.48 High High
opioid receptor 2 62.32 Quite High
Disease Link Frequency Relevance Heat
Glioma 24 99.00 Very High Very High Very High
Neuroblastoma 24 98.74 Very High Very High Very High
Anxiety Disorder 1 94.64 High High
Pain 1 92.60 High High
Stress 7 86.80 High High
Increased Venous Pressure Under Development 19 85.40 High High
Coronary Artery Disease 5 78.12 Quite High
Diabetes Mellitus 30 75.08 Quite High
Diabetic Retinopathy 6 67.48 Quite High
Impaired Glucose Tolerance 6 61.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ontogeny of gene expression of adenosine A2 receptor in the striatum: early localization in the patch compartment.
Gene_expression (expression) of adenosine A2 receptor in striatum associated with adenocard
1) Confidence 0.73 Published 1992 Journal J. Comp. Neurol. Section Title Doc Link 1573059 Disease Relevance 0 Pain Relevance 0.56
These results demonstrate that there is a high expression of adenosine A2A receptor mRNA in the primate striatum that is extensively co-localized with dopamine D2 receptor and preproenkephalin A mRNAs.
Gene_expression (expression) of adenosine A2A receptor in striatum associated with dopamine and adenocard
2) Confidence 0.64 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9721905 Disease Relevance 0 Pain Relevance 0.65
The cellular expression of adenosine A2A receptor mRNA in the adult monkey and human striatum was examined by using single and double in situ hybridization with ribonucleotide probes.
Spec (examined) Gene_expression (expression) of adenosine A2A receptor in striatum associated with adenocard
3) Confidence 0.64 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9721905 Disease Relevance 0 Pain Relevance 0.23
By contrast, high expression of preproenkephalin A mRNA but no expression of adenosine A2A receptor mRNA was found in the nucleus basalis of Meynert.
Gene_expression (expression) of adenosine A2A receptor in nucleus associated with adenocard
4) Confidence 0.64 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9721905 Disease Relevance 0 Pain Relevance 0.43
Analysis on adjacent sections demonstrated a homogeneous overlapping expression of adenosine A2A receptor and preproenkephalin A mRNAs throughout nucleus caudatus, putamen, and nucleus accumbens.
Gene_expression (expression) of adenosine A2A receptor in putamen associated with nucleus accumbens and adenocard
5) Confidence 0.64 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9721905 Disease Relevance 0 Pain Relevance 0.32
In addition, a sub-population of adenosine A2A receptor mRNA-expressing neurons that also contained preproenkephalin A mRNA was found in the septum in monkeys.
Gene_expression (mRNA-expressing) of adenosine A2A receptor in neurons associated with adenocard
6) Confidence 0.64 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9721905 Disease Relevance 0 Pain Relevance 0.70
The adenosine receptors A1 (ADORA1), A2A (ADORA2A), A2B (ADORA2B), and A3 (ADORA3) group together, indicating overlap in ligand profiles.
Gene_expression (group) of A2A associated with adenocard
7) Confidence 0.30 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2897831 Disease Relevance 0 Pain Relevance 0.24
Additionally, receptor selectivity may vary with relatively small changes in ligand structure: an 8-cycloalkyl substituent on theophylline confers A1 receptor selectivity, whereas a phenylstyryl substituent on the same position in caffeine renders these compounds selective for the A2A receptor.
Gene_expression (selective) of A2A receptor
8) Confidence 0.30 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2897831 Disease Relevance 0 Pain Relevance 0.23
The mouse neuroblastoma x rat glioma hybrid cell line had previously been proposed to express adenosine A2A as well as adenosine A2B receptors on the basis of functional assays [20].
Gene_expression (express) of adenosine A2A associated with neuroblastoma, adenocard and glioma
9) Confidence 0.26 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096648 Disease Relevance 0.20 Pain Relevance 0.42
With a Ki value of 5 ┬ÁM at human adenosine A2A receptors [3H]PSB-298 is highly selective for adenosine A2B over A2A receptors [16].
Gene_expression (selective) of adenosine A2A associated with adenocard
10) Confidence 0.22 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096648 Disease Relevance 0 Pain Relevance 0.72
Thus, adenosine A2A receptors were not detectable under the applied conditions of radioligand binding studies.


Neg (not) Gene_expression (detectable) of adenosine A2A associated with adenocard
11) Confidence 0.22 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096648 Disease Relevance 0.18 Pain Relevance 0.46
With this method, however, they only detected adenosine A2A but not A2B message in NG108-15 cells [35].
Gene_expression (message) of adenosine A2A in NG108-15 associated with adenocard
12) Confidence 0.22 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096648 Disease Relevance 0.17 Pain Relevance 0.59
These experiments suggest that the expression level of adenosine A2B receptors is much higher than that of adenosine A2A receptors in NG108-15 cells.
Gene_expression (expression) of adenosine A2A in NG108-15 associated with adenocard
13) Confidence 0.22 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096648 Disease Relevance 0.13 Pain Relevance 0.68
Analysis on adjacent sections demonstrated a homogeneous overlapping expression of adenosine A2A receptor and preproenkephalin A mRNAs throughout nucleus caudatus, putamen, and nucleus accumbens.
Gene_expression (expression) of adenosine A2A receptor in nucleus accumbens associated with nucleus accumbens and adenocard
14) Confidence 0.22 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9721905 Disease Relevance 0 Pain Relevance 0.32
Thus, the radioligand appears to be selective for A2B receptors in these cells; however, at present, it is not known whether the cells express enough adenosine A2A and A3 subtype receptors to reveal full selectivity.
Spec (whether) Gene_expression (express) of adenosine A2A associated with adenocard
15) Confidence 0.20 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096648 Disease Relevance 0.20 Pain Relevance 0.57
Since the discovery of the prototypical A2A agonist CGS-21680 in 1989, several potent, selective A2A adenosine receptor agonists have been synthesized, and preliminary experimental studies have been promising.
Gene_expression (synthesized) of A2A adenosine receptor associated with adenocard and agonist
16) Confidence 0.08 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2496979 Disease Relevance 0.45 Pain Relevance 0.48
Heterologous expression and comparative characterization of the human neuromedin U subtype II receptor using the methylotrophic yeast Pichia pastoris and mammalian cells.
Gene_expression (expression) of subtype II receptor associated with neuropeptide
17) Confidence 0.02 Published 2007 Journal Int. J. Biochem. Cell Biol. Section Title Doc Link 17445746 Disease Relevance 0.19 Pain Relevance 0.19

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