INT115695

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Context Info
Confidence 0.22
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.23
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATXN1) cell death (ATXN1) nucleolus (ATXN1)
RNA binding (ATXN1) nucleus (ATXN1) DNA binding (ATXN1)
Anatomy Link Frequency
nucleus 2
ATXN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 5 98.46 Very High Very High Very High
Pain 4 93.64 High High
Buprenorphine 2 90.96 High High
Analgesic 1 89.88 High High
Codeine 1 89.52 High High
Morphine 3 83.92 Quite High
Disease Link Frequency Relevance Heat
Sickle Cell Anemia 7 100.00 Very High Very High Very High
Spinocerebellar Ataxia Type 2 2 97.52 Very High Very High Very High
Pain 2 93.64 High High
Targeted Disruption 7 75.00 Quite High
Stress 4 62.28 Quite High
Retinoblastoma 102 5.00 Very Low Very Low Very Low
Infection 22 5.00 Very Low Very Low Very Low
Viral Infection 20 5.00 Very Low Very Low Very Low
Cancer 12 5.00 Very Low Very Low Very Low
Epstein-barr Virus 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We co-transfected cells with the CHPKs and FLAG-tagged derivatives of either Atx1(Q82) or Atx1(Q82)-K772T that form aggregates in the nucleus and cytoplasm, respectively [90].
Positive_regulation (derivatives) of Atx1 in nucleus
1) Confidence 0.22 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2936540 Disease Relevance 0.16 Pain Relevance 0
We co-transfected cells with the CHPKs and FLAG-tagged derivatives of either Atx1(Q82) or Atx1(Q82)-K772T that form aggregates in the nucleus and cytoplasm, respectively [90].
Positive_regulation (derivatives) of Atx1 in nucleus
2) Confidence 0.22 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2936540 Disease Relevance 0.16 Pain Relevance 0
The current study investigated the in vitro hepatic metabolism of opioids in mouse models of sickle cell anemia, with the hypothesis that higher dose requirements in SCA could be explained by an increased metabolism rate of opioids.
Positive_regulation (requirements) of SCA associated with sickle cell anemia and opioid
3) Confidence 0.00 Published 2004 Journal Drug Metab. Dispos. Section Abstract Doc Link 14709626 Disease Relevance 0.91 Pain Relevance 0.98

General Comments

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