INT115696

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Context Info
Confidence 0.03
First Reported 2003
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.36
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal 2
Col6a6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 8 97.88 Very High Very High Very High
Thermal hyperalgesia 3 97.00 Very High Very High Very High
allodynia 1 89.04 High High
Dorsal horn 1 79.96 Quite High
qutenza 3 75.00 Quite High
nMDA receptor 1 75.00 Quite High
central sensitization 3 62.96 Quite High
Neuropathic pain 1 57.08 Quite High
Neuritis 2 50.00 Quite Low
Spinal cord 1 43.08 Quite Low
Disease Link Frequency Relevance Heat
Injury 9 97.88 Very High Very High Very High
Hyperalgesia 3 97.00 Very High Very High Very High
Neuropathic Pain 5 96.04 Very High Very High Very High
Experimental Autoimmune Neuritis 2 81.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There were no significant changes of the expression of alpha6 and laminin both in the acute phase and recovery phase of EANs by immunohistochemistry (alpha6 P=0.0751;laminin P=0.2047).
Neg (no) Regulation (changes) of Gene_expression (expression) of alpha6
1) Confidence 0.03 Published 2003 Journal Beijing Da Xue Xue Bao Section Body Doc Link 14710253 Disease Relevance 0.08 Pain Relevance 0
These findings demonstrate that the increased expression of NR1 and pNR1 in spinal laminae I-II and V-VI is dependent on activation of CSPAs, which ultimately contribute to the development of thermal hyperalgesia in neuropathic rats.
Regulation (dependent) of Gene_expression (expression) of V-VI in spinal associated with thermal hyperalgesia and neuropathic pain
2) Confidence 0.01 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17933570 Disease Relevance 1.28 Pain Relevance 0.95

General Comments

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