INT115717

Context Info Confidence 0.49 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.56 Pain Relevance 0.09

signal transduction (TNF, PLAU) extracellular space (TNF, PLAU) extracellular region (TNF, PLAU) plasma membrane (TNF, PLAU) peptidase activity (PLAU) intracellular (TNF)

Anatomy Link Frequency fibroblasts 2 TNF (Homo sapiens) PLAU (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 3 99.22 cINOD 1 25.00

Disease Link Frequency Relevance Heat Cancer 1 100.00 Necrosis 1 100.00 Peptic Ulcer 1 99.88 INFLAMMATION 4 99.22 Injury 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To clarify the role of human gastric fibroblasts in acute inflammatory conditions such as gastric ulcer, the effects of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha on the expression of uPA and uPAR, which were suggested to be associated with tissue remodeling, in gastric fibroblasts were investigated.

TNF Regulation (effects) of Gene_expression (expression) of uPA in fibroblasts associated with necrosis, inflammation, cancer and peptic ulcer

1) Confidence 0.49 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.56 Pain Relevance 0.09

General Comments

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