INT115721

Context Info Confidence 0.67 First Reported 2002 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 11 Total Number 11 Disease Relevance 7.66 Pain Relevance 1.55

peptidase activity (PLAU) signal transduction (PLAU) extracellular space (PLAU) extracellular region (PLAU) plasma membrane (PLAU)

Anatomy Link Frequency colon 4 ZR-75-1 2 epithelial cells 2 PGE2 2 PLAU (Homo sapiens)

Pain Link Frequency Relevance Heat palliative 2 97.32 Inflammation 68 97.08 fibrosis 79 95.76 cytokine 5 88.40 cINOD 22 87.92 methotrexate 1 85.64 metalloproteinase 60 73.84 chemokine 1 71.96 aspirin 15 5.00 COX2 4 5.00

Disease Link Frequency Relevance Heat Colon Cancer 121 99.84 Pneumonia 3 99.66 Cancer 113 99.36 Breast Cancer 111 99.28 Advanced Or Metastatic Breast Cancer 1 99.28 INFLAMMATION 74 97.08 Pulmonary Fibrosis 63 95.76 Apoptosis 62 94.80 Necrosis 8 93.48 Peptic Ulcer 3 91.16

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Celecoxib caused phosphorylation of eukaryotic translation initiation factor 2 kinase (PERK) and eukaryotic initiation factor-2alpha (eIF2alpha) and production of activating transcription factor (ATF)4 mRNA.

Positive_regulation (caused) of Gene_expression (production) of ATF

1) Confidence 0.67 Published 2006 Journal Oncogene Section Abstract Doc Link 16205636 Disease Relevance 0.81 Pain Relevance 0.47

The expression level of uPA mRNA and the amount of uPA antigen increased significantly on treatment with each concentration of IL-1beta (1 and 10 ng/ml) and 10 ng/ml TNF-alpha.

Positive_regulation (increased) of Gene_expression (expression) of uPA mRNA

2) Confidence 0.67 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.52 Pain Relevance 0.09

Nevertheless, in metastatic breast cancer, retrospective studies showed that elevated uPA or PAI-1 present in the primary tumor are associated with a poor response to later palliative endocrine therapy [14] suggesting that high levels of uPA and/or PAI-1 do reflect an aggressive phenotype that may be overcome by early systemic therapy in the adjuvant setting but not by palliative therapy at a later stage of the disease.

Positive_regulation (elevated) of Gene_expression (present) of uPA associated with cancer, disease, advanced or metastatic breast cancer and palliative

3) Confidence 0.49 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.86 Pain Relevance 0.23

Protein expression of urokinase-type plasminogen activator (PLAU) was reported to be higher in colon tumours than in normal colon tissue [35].

Positive_regulation (higher) of Gene_expression (expression) of PLAU in colon associated with colon cancer

4) Confidence 0.49 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.51 Pain Relevance 0

The expression level of uPAR mRNA and the amount of uPA antigen on cell surfaces increased in a dose-dependent manner on treatment with PGE2 (10 and 50 ng/ml).

Positive_regulation (increased) of Gene_expression (expression) of uPA in PGE2

5) Confidence 0.48 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.22 Pain Relevance 0.13

The expression level of uPA mRNA and the amount of uPA antigen increased significantly on treatment with each concentration of IL-1beta (1 and 10 ng/ml) and 10 ng/ml TNF-alpha.

Positive_regulation (increased) of Gene_expression (expression) of uPA

6) Confidence 0.48 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.52 Pain Relevance 0.09

In addition, expression of urokinase-type plasminogen activator receptor (PLAUR) was upregulated by curcumin (Figure 3).

Positive_regulation (upregulated) of Gene_expression (expression) of urokinase-type plasminogen activator

7) Confidence 0.35 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.46 Pain Relevance 0

Protein expression of urokinase-type plasminogen activator (PLAU) was reported to be higher in colon tumours than in normal colon tissue [35].

Positive_regulation (reported) of Gene_expression (expression) of urokinase-type plasminogen activator in colon associated with colon cancer

8) Confidence 0.35 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.51 Pain Relevance 0

there was increased expression of both u-PA and u-PAR by the breast cancer cells (Fig. 4B; ZR-75-1 cells shown, results similar with all 3 breast cancer cell lines.).

Positive_regulation (increased) of Gene_expression (expression) of u-PA in ZR-75-1 associated with breast cancer

9) Confidence 0.25 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 1.08 Pain Relevance 0.14

Indeed, elevated levels of uPA and PAI-1 are associated with poor clinical outcome in breast cancer and also have predictive value [33-35].

Positive_regulation (elevated) of Gene_expression (levels) of uPA associated with breast cancer

10) Confidence 0.20 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779463 Disease Relevance 1.33 Pain Relevance 0.16

Furthermore, it has recently been found that whereas cryptogenic organizing pneumonia lesions have an increased expression of urokinase-type plasminogen activator, especially in the lining of epithelial cells around the fibroblastic plugs, the predominant staining in IPF lungs was for PAI-1, which was also in the epithelial cells lining the enlarged, restructured airspaces [42].

Positive_regulation (increased) of Gene_expression (expression) of urokinase-type plasminogen activator in epithelial cells associated with fibrosis and pneumonia

11) Confidence 0.16 Published 2002 Journal Respir Res Section Body Doc Link PMC64814 Disease Relevance 0.83 Pain Relevance 0.25

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