INT115733

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.62
Pain Relevance 7.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Faah) Golgi apparatus (Faah) endoplasmic reticulum (Faah)
cytoplasm (Faah)
Anatomy Link Frequency
Spinal 2
medulla 2
nervous tissue 2
brain 2
Faah (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endocannabinoid 28 100.00 Very High Very High Very High
Cannabinoid 20 100.00 Very High Very High Very High
qutenza 4 100.00 Very High Very High Very High
COX2 4 100.00 Very High Very High Very High
Serotonin 2 100.00 Very High Very High Very High
analgesia 20 99.96 Very High Very High Very High
Pain 10 99.92 Very High Very High Very High
Analgesic 8 99.80 Very High Very High Very High
dorsal root ganglion 9 99.24 Very High Very High Very High
IPN 3 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 5 99.92 Very High Very High Very High
Stress 7 99.48 Very High Very High Very High
Ganglion Cysts 9 99.24 Very High Very High Very High
Inflammatory Pain 3 98.48 Very High Very High Very High
Urological Neuroanatomy 9 97.72 Very High Very High Very High
Hypersensitivity 1 97.68 Very High Very High Very High
Nociception 4 88.56 High High
Shock 3 83.00 Quite High
Neuropathic Pain 4 82.32 Quite High
INFLAMMATION 4 78.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been demonstrated that the inhibition of the FAAH by URB597 increases levels of anandamide, oleoylethanolamide and palmitoylethanolamide in the brain of rats.
Positive_regulation (increases) of Negative_regulation (inhibition) of FAAH in brain
1) Confidence 0.50 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17336288 Disease Relevance 0 Pain Relevance 0.18
Inhibition of FAAH activity increases AEA concentrations in nervous tissue and reduces sensory hypersensitivity in animal pain models.
Positive_regulation (increases) of Negative_regulation (Inhibition) of FAAH in nervous tissue associated with pain and hypersensitivity
2) Confidence 0.50 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19321773 Disease Relevance 0.80 Pain Relevance 0.67
Augmentation of levels of endocannabinoids with inhibitors of fatty acid amide hydrolase (FAAH) is analgesic in models of acute and inflammatory pain states.
Positive_regulation (Augmentation) of Negative_regulation (inhibitors) of fatty acid amide hydrolase associated with endocannabinoid, ipn and analgesic
3) Confidence 0.50 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17182782 Disease Relevance 0.44 Pain Relevance 0.82
Augmentation of levels of endocannabinoids with inhibitors of fatty acid amide hydrolase (FAAH) is analgesic in models of acute and inflammatory pain states.
Positive_regulation (Augmentation) of Negative_regulation (inhibitors) of FAAH associated with endocannabinoid, ipn and analgesic
4) Confidence 0.50 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17182782 Disease Relevance 0.44 Pain Relevance 0.82
Anandamide uptake inhibition, but not blockade of FAAH, effectively increases synaptic concentrations of endocannabinoids.
Positive_regulation (increases) of Neg (not) Negative_regulation (blockade) of FAAH associated with endocannabinoid
5) Confidence 0.48 Published 2004 Journal Brain Res. Section Abstract Doc Link 14715144 Disease Relevance 0 Pain Relevance 0.73
Spinal inhibition of FAAH, with either URB597 or arachidonoyl serotonin (AA-5-HT), also enhanced SIA through a CB1-mediated mechanism, presumably by increasing accumulation of tonically released anandamide.
Positive_regulation (enhanced) of Negative_regulation (inhibition) of FAAH in Spinal associated with serotonin and analgesia
6) Confidence 0.48 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16316669 Disease Relevance 0.35 Pain Relevance 1.28
Inhibition of fatty-acid amide hydrolase enhances cannabinoid stress-induced analgesia: sites of action in the dorsolateral periaqueductal gray and rostral ventromedial medulla.
Positive_regulation (enhances) of Negative_regulation (Inhibition) of fatty-acid amide hydrolase in medulla associated with stress, cannabinoid, central grey, rostral ventromedial medulla and analgesia
7) Confidence 0.26 Published 2005 Journal Neuropharmacology Section Title Doc Link 16129456 Disease Relevance 0.95 Pain Relevance 1.70
Inhibition of fatty acid amide hydrolase and cyclooxygenase-2 increases levels of endocannabinoid related molecules and produces analgesia via peroxisome proliferator-activated receptor-alpha in a model of inflammatory pain.
Positive_regulation (increases) of Negative_regulation (Inhibition) of fatty acid amide hydrolase associated with endocannabinoid, ipn, cox2 and analgesia
8) Confidence 0.23 Published 2008 Journal Neuropharmacology Section Title Doc Link 18534634 Disease Relevance 0.63 Pain Relevance 1.05

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