INT115737

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.00
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Faah) Golgi apparatus (Faah) endoplasmic reticulum (Faah)
cytoplasm (Faah)
Anatomy Link Frequency
blood 2
Faah (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endocannabinoid 8 99.68 Very High Very High Very High
Analgesic 13 96.72 Very High Very High Very High
Cannabinoid 6 95.72 Very High Very High Very High
Delta-9-tetrahydrocannabinol 1 93.92 High High
Neurotransmitter 9 92.72 High High
cannabis 1 92.08 High High
Neuropeptide 4 90.96 High High
Pain 39 90.88 High High
Cannabinoid receptor 2 89.04 High High
Spinal cord 3 86.72 High High
Disease Link Frequency Relevance Heat
Pain 35 90.88 High High
Nervous System Injury 1 77.68 Quite High
INFLAMMATION 7 76.32 Quite High
Headache 77 72.96 Quite High
Cluster Headache 6 69.84 Quite High
Nociception 18 67.68 Quite High
Injury 3 59.20 Quite High
Neurogenic Inflammation 8 31.72 Quite Low
Depression 9 5.00 Very Low Very Low Very Low
Vomiting 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NAGly is a potent inhibitor of the fatty acid amide hydrolase (FAAH), the enzyme primarily responsible for the degradation of the endocannabinoid N-arachidonoyl-ethanolamine (anandamide), and was shown recently to elevate the blood levels of the this analgesic compound.
Regulation (responsible) of Protein_catabolism (degradation) of FAAH in blood associated with endocannabinoid and analgesic
1) Confidence 0.44 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 14715265 Disease Relevance 0 Pain Relevance 0.27
To address this question, we developed a peripherally restricted inhibitor (URB937) of fatty acid amide hydrolase (FAAH), the enzyme responsible for the degradation of the endocannabinoid anandamide.
Regulation (responsible) of Protein_catabolism (degradation) of FAAH associated with endocannabinoid
2) Confidence 0.40 Published 2010 Journal Nat. Neurosci. Section Abstract Doc Link 20852626 Disease Relevance 0.52 Pain Relevance 0.76
The synthesis of anandamide is regulated by the phospholipase D, while another intracellular enzyme, the Fatty Acid Amide Hydrolase (FAAH) is responsible of its degradation, followed by the reassumption of its constituents in phospholipids [31].
Regulation (responsible) of Protein_catabolism (degradation) of Fatty Acid Amide Hydrolase
3) Confidence 0.13 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2771268 Disease Relevance 0.48 Pain Relevance 0.74

General Comments

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