INT115753

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Context Info
Confidence 0.38
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nav1) cytoskeleton (Nav1) cytoplasm (Nav1)
Nav1 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 3 84.48 Quite High
addiction 1 81.48 Quite High
sodium channel 6 75.00 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In med cells, the resurgent component of beta-PMTX-modified sodium currents could be selectively abolished by application of intracellular alkaline phosphatase, suggesting that, like in NaV1.6-expressing cells, the open-channel block of NaV1.1 and NaV1.2 subunits is regulated by constitutive phosphorylation.
Regulation (regulated) of Negative_regulation (block) of NaV1
1) Confidence 0.38 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14715935 Disease Relevance 0 Pain Relevance 0.16
In med cells, the resurgent component of beta-PMTX-modified sodium currents could be selectively abolished by application of intracellular alkaline phosphatase, suggesting that, like in NaV1.6-expressing cells, the open-channel block of NaV1.1 and NaV1.2 subunits is regulated by constitutive phosphorylation.
Regulation (regulated) of Negative_regulation (block) of NaV1
2) Confidence 0.38 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14715935 Disease Relevance 0 Pain Relevance 0.16
In this 'neonatal K211D' mutant, the electrophysiological parameters studied strongly shifted back towards the 'adult', that is the lysine residue was primarily responsible for the electrophysiological effects of Nav1.5 D1:S3 splicing.
Regulation (responsible) of Negative_regulation (effects) of Nav1
3) Confidence 0.15 Published 2008 Journal J. Cell. Physiol. Section Abstract Doc Link 18393272 Disease Relevance 0 Pain Relevance 0.13

General Comments

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