INT115770

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.94
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) oxidoreductase activity (Ptgs2) endoplasmic reticulum (Ptgs2)
nucleus (Ptgs2) enzyme binding (Ptgs2) protein complex (Ptgs2)
Anatomy Link Frequency
macrophages 4
alveolar macrophages 2
Ptgs2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 10 89.32 High High
Antinociceptive 5 88.96 High High
Freund adjuvant 1 88.32 High High
Hyperalgesia 1 87.04 High High
IPN 1 85.52 High High
Pain 3 71.00 Quite High
tail-flick 1 69.00 Quite High
Analgesic 8 65.24 Quite High
spastic colon 2 50.00 Quite Low
COX2 5 25.00 Low Low
Disease Link Frequency Relevance Heat
Convulsion 2 95.00 High High
INFLAMMATION 9 89.32 High High
Hyperalgesia 1 87.04 High High
Inflammatory Pain 1 85.52 High High
Pain 1 71.00 Quite High
Disease 1 69.00 Quite High
Pressure And Volume Under Development 1 67.96 Quite High
Functional Bowel Disorder 2 50.00 Quite Low
Nociception 1 50.00 Quite Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was accompanied by alterations in the microbiota and an upregulation of cyclooxygenase-2 which could be reversed by treatment with anti-inflammatory agents or selected probiotics.
Negative_regulation (reversed) of Positive_regulation (upregulation) of cyclooxygenase-2
1) Confidence 0.43 Published 2009 Journal Dig Dis Section Body Doc Link 20203502 Disease Relevance 0.07 Pain Relevance 0
Finally, in primary cultures of rat alveolar macrophages, HN and compounds 1, 2, 6, and 7 (10(-8) M) significantly blocked lipopolysaccharide-induced cyclooxygenase-2 induction and prostaglandin E(2) secretion.
Negative_regulation (blocked) of Positive_regulation (induction) of cyclooxygenase-2 in alveolar macrophages
2) Confidence 0.43 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14718586 Disease Relevance 0.50 Pain Relevance 0.55
SC suppressed production of nitric oxide and induction of iNOS and cyclooxygenase-2 in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages.
Negative_regulation (suppressed) of Positive_regulation (induction) of cyclooxygenase-2 in macrophages
3) Confidence 0.42 Published 2008 Journal J Ethnopharmacol Section Body Doc Link 18790036 Disease Relevance 0.21 Pain Relevance 0
However, LJ was unable to suppress induction of cyclooxygenase-2 in the stimulated macrophage cells.
Neg (unable) Negative_regulation (suppress) of Positive_regulation (induction) of cyclooxygenase-2 in macrophage
4) Confidence 0.40 Published 2008 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 18498715 Disease Relevance 0.16 Pain Relevance 0.24

General Comments

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