INT115773

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 6
Total Number 6
Disease Relevance 2.99
Pain Relevance 3.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) oxidoreductase activity (Ptgs2) endoplasmic reticulum (Ptgs2)
nucleus (Ptgs2) enzyme binding (Ptgs2) protein complex (Ptgs2)
Anatomy Link Frequency
testis 4
alveolar macrophages 2
vas deferens 2
Ptgs2 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 102 100.00 Very High Very High Very High
COX2 8 100.00 Very High Very High Very High
cOX1 2 100.00 Very High Very High Very High
glial activation 3 92.76 High High
Antinociceptive 2 91.60 High High
COX-2 inhibitor 6 91.20 High High
Inflammation 66 88.88 High High
Freund adjuvant 1 88.32 High High
Hyperalgesia 1 87.04 High High
cytokine 20 85.84 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 84 98.40 Very High Very High Very High
Disease 86 96.44 Very High Very High Very High
Convulsion 2 95.00 High High
Nephrotoxicity 2 92.08 High High
Hyperalgesia 1 87.04 High High
Inflammatory Pain 1 85.52 High High
Obesity 5 82.44 Quite High
Dementia 4 80.60 Quite High
Pain 1 71.00 Quite High
Cognitive Disorder 19 61.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, in primary cultures of rat alveolar macrophages, HN and compounds 1, 2, 6, and 7 (10(-8) M) significantly blocked lipopolysaccharide-induced cyclooxygenase-2 induction and prostaglandin E(2) secretion.
Negative_regulation (blocked) of Localization (secretion) of cyclooxygenase-2 in alveolar macrophages
1) Confidence 0.43 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14718586 Disease Relevance 0.50 Pain Relevance 0.55
Localization of cyclooxygenase-2 in mice testis and assessment of its possible role through suppressing its expression using nimesulide: a preferential cyclooxygenase-2 inhibitor.
Negative_regulation (inhibitor) of Localization (Localization) of cyclooxygenase-2 in testis associated with cox2
2) Confidence 0.29 Published 2007 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Title Doc Link 17624748 Disease Relevance 0.28 Pain Relevance 0.47
Localization of cyclooxygenase-2 in mice testis and assessment of its possible role through suppressing its expression using nimesulide: a preferential cyclooxygenase-2 inhibitor.
Negative_regulation (inhibitor) of Localization (Localization) of cyclooxygenase-2 in testis associated with cox2
3) Confidence 0.29 Published 2007 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Title Doc Link 17624748 Disease Relevance 0.28 Pain Relevance 0.47
Localization of cyclooxygenase-2 in mice vas deferens and its effects on fertility upon suppression using nimesulide: a preferential cyclooxygenase-2 inhibitor.
Negative_regulation (inhibitor) of Localization (Localization) of cyclooxygenase-2 in vas deferens associated with cox1
4) Confidence 0.23 Published 2007 Journal Toxicology Section Title Doc Link 17382448 Disease Relevance 0.18 Pain Relevance 0.52
The inhibition of the canonical targets of NSAIDs, cyclooxygenase-1 and -2 (COX-1 and COX-2), do not seem to be responsible for the protective effect of NSAIDs in AD (see review Lleo et al., 2007).
Negative_regulation (inhibition) of Localization (targets) of cyclooxygenase-1 and -2 associated with cinod and disease
5) Confidence 0.14 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2893374 Disease Relevance 1.26 Pain Relevance 0.65
However, the inhibition of the canonical targets of NSAIDs, cyclooxygenase-1 and -2 (COX-1 and COX-2), do not seem to be responsible for the protective effect of NSAIDs in AD.
Negative_regulation (inhibition) of Localization (targets) of cyclooxygenase-1 and -2 associated with cinod and disease
6) Confidence 0.12 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.49 Pain Relevance 1.15

General Comments

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