INT115782

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Context Info
Confidence 0.33
First Reported 2004
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.85
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCND3) transmembrane transport (KCND3)
Anatomy Link Frequency
smooth muscle cells 2
oocytes 1
KCND3 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 2 100.00 Very High Very High Very High
Opioid 44 99.84 Very High Very High Very High
agonist 11 98.60 Very High Very High Very High
alcohol 126 98.12 Very High Very High Very High
Potency 2 98.00 Very High Very High Very High
Kappa opioid receptor 6 91.52 High High
MU agonist 2 85.16 High High
tetrodotoxin 2 78.68 Quite High
Dynorphin 1 63.68 Quite High
addiction 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 66 100.00 Very High Very High Very High
Nicotine Addiction 132 97.20 Very High Very High Very High
Manic Depressive Disorder 2 70.28 Quite High
Depressive Disorder 2 69.76 Quite High
Somatoform Disorder 4 66.68 Quite High
Drug Dependence 4 63.04 Quite High
Depression 2 61.04 Quite High
Disease 6 5.00 Very Low Very Low Very Low
Mental Disorders 4 5.00 Very Low Very Low Very Low
Sleep Initiation And Maintenance Disorders 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other medicament users were defined as using neither SHA nor opioids but other medicaments.
Neg (neither) Gene_expression (using) of SHA associated with anxiety disorder and opioid
1) Confidence 0.33 Published 2007 Journal BMC Public Health Section Body Doc Link PMC2213670 Disease Relevance 1.12 Pain Relevance 0.57
The proportions of SHA or opioid users seem to be lower than those found in other research [3].
Gene_expression (proportions) of SHA associated with anxiety disorder and opioid
2) Confidence 0.33 Published 2007 Journal BMC Public Health Section Body Doc Link PMC2213670 Disease Relevance 0.73 Pain Relevance 0.41
Acute and chronic effects of eicosapentaenoic acid on voltage-gated sodium channel expressed in cultured human bronchial smooth muscle cells.
Gene_expression (expressed) of on voltage-gated in smooth muscle cells associated with sodium channel
3) Confidence 0.05 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 15883037 Disease Relevance 0 Pain Relevance 0.13
This study investigated acute and chronic effects of eicosapentaenoic acid (EPA) on voltage-gated Na+ current (I(Na)) expressed in cultured human bronchial smooth muscle cells (hBSMCs).
Gene_expression (expressed) of on voltage-gated in smooth muscle cells
4) Confidence 0.05 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15883037 Disease Relevance 0 Pain Relevance 0.11
Because issues of receptor reserve complicate estimates of agonist efficacy and potency, we also examined the agonist actions of salvinorin A by measuring potassium conductance through G protein-gated K(+) channels coexpressed in Xenopus oocytes, a system in which receptor reserve is minimal.
Gene_expression (coexpressed) of protein-gated K in oocytes associated with agonist and potency
5) Confidence 0.02 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14718611 Disease Relevance 0 Pain Relevance 0.85

General Comments

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