INT115790

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Context Info
Confidence 0.47
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.13
Pain Relevance 3.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (P2rx6)
Anatomy Link Frequency
sensory neurons 2
cortex 1
microglia 1
peripheral neurons 1
P2rx6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 31 99.98 Very High Very High Very High
Neuropathic pain 70 98.52 Very High Very High Very High
Migraine 1 97.44 Very High Very High Very High
Stimulus evoked pain 6 95.60 Very High Very High Very High
Lasting pain 12 95.40 Very High Very High Very High
Pain 32 95.20 Very High Very High Very High
Analgesic 14 94.52 High High
dorsal root ganglion 74 94.40 High High
Brush evoked pain 25 93.84 High High
cINOD 2 90.12 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 60 98.84 Very High Very High Very High
Neuropathic Pain 139 98.52 Very High Very High Very High
Headache 1 97.44 Very High Very High Very High
Pain 50 95.60 Very High Very High Very High
Hypersensitivity 9 95.40 Very High Very High Very High
Ganglion Cysts 76 94.40 High High
INFLAMMATION 22 89.92 High High
Injury 56 89.36 High High
Cv Unclassified Under Development 16 80.60 Quite High
Nerve Compression Syndromes 45 74.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ionized form is likely to be responsible for the suppression of the P2X3 receptor current, which may result in a reduction of the excitability of central and peripheral neurons and may contribute to the anesthetic and analgesic actions of the agent.
Negative_regulation (suppression) of P2X3 receptor in peripheral neurons associated with analgesic
1) Confidence 0.47 Published 2003 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 14719026 Disease Relevance 0.31 Pain Relevance 0.22
In fact, the new acyclic nucleotides are able to persistently block (by desensitization) P2X3 receptor activity after a brief, modest activation, yet leaving the ability of sensory neurons to mediate responses to standard painful stimuli via a lower level of signaling.
Negative_regulation (block) of P2X3 receptor in sensory neurons associated with pain
2) Confidence 0.43 Published 2009 Journal J. Med. Chem. Section Abstract Doc Link 19606867 Disease Relevance 0.29 Pain Relevance 0.43
The present study used patch-clamp recording from cultured rat or mouse sensory neurons and kinetic modeling to clarify the properties of P2X3 receptor desensitization.
Negative_regulation (desensitization) of P2X3 receptor in sensory neurons
3) Confidence 0.41 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16627751 Disease Relevance 0.09 Pain Relevance 0.27
Enhanced migration into the cortex induced by P2X receptor blockade during OGD was also suggested by cell spreading observed by DCX immunofluorescence 24 hours after PPADS/OGD treatment (Figure 3A).
Negative_regulation (blockade) of P2X receptor in cortex
4) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669296 Disease Relevance 0 Pain Relevance 0
Messenger RNAs of P2X5 and P2X6 are increased and decreased, respectively, in the injured DRG [124].
Negative_regulation (decreased) of P2X6
5) Confidence 0.25 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 1.01 Pain Relevance 0.46
Confocal microscopic analysis with OX 42 [39] at organotypic cultures showed that P2X4 and P2X7 are expressed on microglia, whereas P2X1 and P2Y1,2,12, although present in the slices, do not colocalize at microglia, and the P2X6 receptor is absent.
Negative_regulation (absent) of P2X6 receptor in microglia
6) Confidence 0.12 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072928 Disease Relevance 0.49 Pain Relevance 0.22
Antidepressants inhibit P2X4 receptor function: a possible involvement in neuropathic pain relief

Background

Negative_regulation (inhibit) of P2X4 receptor associated with antidepressant and neuropathic pain
7) Confidence 0.03 Published 2009 Journal Mol Pain Section Title Doc Link PMC2680826 Disease Relevance 0.95 Pain Relevance 1.23
At this extracellular [ATP], some degree of P2X3 receptor desensitization would be expected [40,41].
Negative_regulation (desensitization) of P2X3 receptor
8) Confidence 0.03 Published 2008 Journal Mol Pain Section Body Doc Link PMC2630978 Disease Relevance 0.99 Pain Relevance 0.36

General Comments

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