INT1158

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Context Info
Confidence 0.61
First Reported 1975
Last Reported 2011
Negated 19
Speculated 18
Reported most in Abstract
Documents 106
Total Number 124
Disease Relevance 29.40
Pain Relevance 30.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agt) aging (Agt) extracellular region (Agt)
extracellular matrix organization (Agt)
Anatomy Link Frequency
brain 7
hypothalamus 5
subfornical organ 4
plasma 4
blood 4
Agt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 116 100.00 Very High Very High Very High
anesthesia 70 100.00 Very High Very High Very High
Clonidine 40 100.00 Very High Very High Very High
agonist 37 100.00 Very High Very High Very High
narcan 32 100.00 Very High Very High Very High
Inflammation 24 100.00 Very High Very High Very High
Enkephalin 18 100.00 Very High Very High Very High
Intracerebroventricular 17 100.00 Very High Very High Very High
adenocard 12 100.00 Very High Very High Very High
noradrenaline 9 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 55 100.00 Very High Very High Very High
Nociception 32 100.00 Very High Very High Very High
Heart Rate Under Development 28 100.00 Very High Very High Very High
Natriuresis 15 100.00 Very High Very High Very High
INFLAMMATION 22 99.86 Very High Very High Very High
Dysmenorrhea 13 99.84 Very High Very High Very High
Hypothermia 3 99.64 Very High Very High Very High
Hypertension 258 99.16 Very High Very High Very High
Cancer 9 99.16 Very High Very High Very High
Injury 16 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The circumventricular structures and the lateral hypothalamus (LH) have been shown to be important for the central action of angiotensin II (ANGII) on water and electrolyte regulation.
Regulation (regulation) of angiotensin II in hypothalamus
1) Confidence 0.61 Published 2000 Journal Brain Res. Bull. Section Abstract Doc Link 10974488 Disease Relevance 0 Pain Relevance 0.04
The circumventricular structures and the lateral hypothalamus (LH) have been shown to be important for the central action of angiotensin II (ANGII) on water and electrolyte regulation.
Regulation (regulation) of ANGII in hypothalamus
2) Confidence 0.61 Published 2000 Journal Brain Res. Bull. Section Abstract Doc Link 10974488 Disease Relevance 0 Pain Relevance 0.04
Using EC33, a selective aminopeptidase A inhibitor which blocks the metabolism of Ang II in Ang III, we previously reported that vasopressin release was under the control of Ang III and not Ang II.
Regulation (control) of Ang II
3) Confidence 0.61 Published 1998 Journal Neuroreport Section Abstract Doc Link 9579673 Disease Relevance 0 Pain Relevance 0.05
Using EC33, a selective aminopeptidase A inhibitor which blocks the metabolism of Ang II in Ang III, we previously reported that vasopressin release was under the control of Ang III and not Ang II.
Regulation (control) of Ang III
4) Confidence 0.61 Published 1998 Journal Neuroreport Section Abstract Doc Link 9579673 Disease Relevance 0 Pain Relevance 0.05
Effect of angiotensin II and norepinephrine on early growth response genes in the rat kidney.
Regulation (Effect) of angiotensin II in kidney
5) Confidence 0.61 Published 1993 Journal Kidney Int. Section Title Doc Link 8455358 Disease Relevance 0 Pain Relevance 0.13
Since Ang II also plays a role in controlling reproductive functions, such as luteinizing hormone and prolactin secretion, the objective of the present study was to evaluate the regulation of Ang II receptors by estradiol (E(2)) and progesterone (P) in areas of the brain involved in homeostatic and reproductive functions, such as the locus coeruleus (LC), median preoptic nucleus (MnPO) and subfornical organ (SFO).
Regulation (regulation) of Ang II in subfornical organ associated with locus ceruleus
6) Confidence 0.61 Published 2005 Journal Brain Res. Section Abstract Doc Link 16297888 Disease Relevance 0.06 Pain Relevance 0.21
Regulation of angiotensin II receptors levels during rat induced pulpitis.
Regulation (Regulation) of angiotensin II associated with inflammation and pulpitis
7) Confidence 0.59 Published 2007 Journal Regul. Pept. Section Title Doc Link 17197045 Disease Relevance 0.56 Pain Relevance 0.44
It was demonstrated that the renin-angiotensin system plays an important role in the pulpal inflammation, with regulation of AngII receptor levels.
Regulation (regulation) of AngII associated with inflammation
8) Confidence 0.59 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17197045 Disease Relevance 0.58 Pain Relevance 0.33
The subfornical organ (SFO) and the lateral hypothalamus (LH) have been shown to be important for the central action of angiotensin II (ANG II) on water and salt regulation.
Regulation (regulation) of ANG II in subfornical organ
9) Confidence 0.56 Published 1999 Journal Brain Res. Bull. Section Abstract Doc Link 10372513 Disease Relevance 0 Pain Relevance 0.31
The subfornical organ (SFO) and the lateral hypothalamus (LH) have been shown to be important for the central action of angiotensin II (ANG II) on water and salt regulation.
Regulation (regulation) of angiotensin II in subfornical organ
10) Confidence 0.56 Published 1999 Journal Brain Res. Bull. Section Abstract Doc Link 10372513 Disease Relevance 0 Pain Relevance 0.31
In this article, alterations in angiotensin II receptor levels in tissue harvested from full-thickness excisional dermal wounds in adult Sprague-Dawley rats were examined.
Spec (examined) Regulation (alterations) of angiotensin II associated with injury
11) Confidence 0.55 Published 1996 Journal Wound Repair Regen Section Abstract Doc Link 17177733 Disease Relevance 0.68 Pain Relevance 0.13
Low concentrations (0.15-15 microM) of sodium sulfide reversibly attenuated the contractile response of the isolated rat uterus to oxytocin without affecting angiotensin II responsiveness.
Neg (without) Regulation (affecting) of angiotensin II in uterus
12) Confidence 0.47 Published 1989 Journal Life Sci. Section Abstract Doc Link 2559275 Disease Relevance 0.07 Pain Relevance 0.07
Furthermore, the use of the endoperoxide/thromboxane blocker (SQ29548, 1 microM) did not alter the effect of Ang II on the normotensive rats but prevented its effect in hypertensive rats.
Regulation (effect) of Ang II associated with hypertension
13) Confidence 0.45 Published 1999 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 10413062 Disease Relevance 0.79 Pain Relevance 0.04
Effect of exogenous angiotensin II on renal tissue nitric oxide and intrarenal circulation in anaesthetized rats.
Regulation (Effect) of angiotensin II associated with anesthesia
14) Confidence 0.45 Published 2004 Journal Acta Physiol. Scand. Section Title Doc Link 15491410 Disease Relevance 0 Pain Relevance 0.10
[Biphasic effect of angiotensin II on conditioned reflectory reaction patterns in albino rats].
Regulation (effect) of angiotensin II
15) Confidence 0.45 Published 1975 Journal Acta Biol. Med. Ger. Section Title Doc Link 1189837 Disease Relevance 0 Pain Relevance 0
Effect of the presynaptic dopaminergic agonist, quinpirole, on the drinking responses of rats to angiotensin II, isoproterenol, and hypertonic saline.
Regulation (Effect) of angiotensin II associated with agonist
16) Confidence 0.45 Published 1986 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 3703906 Disease Relevance 0.07 Pain Relevance 0.44
Late-pregnant (18-20 days) and virgin rats were studied under anesthesia or while awake to investigate the effect of acute angiotensin II (ANG II) inhibition (with saralasin or captopril) on mean arterial blood pressure (AP) and renal hemodynamics.
Spec (investigate) Regulation (effect) of ANG II in blood associated with anesthesia
17) Confidence 0.45 Published 1986 Journal Am. J. Physiol. Section Abstract Doc Link 3511733 Disease Relevance 0 Pain Relevance 0.10
Late-pregnant (18-20 days) and virgin rats were studied under anesthesia or while awake to investigate the effect of acute angiotensin II (ANG II) inhibition (with saralasin or captopril) on mean arterial blood pressure (AP) and renal hemodynamics.
Spec (investigate) Regulation (effect) of angiotensin II in blood associated with anesthesia
18) Confidence 0.45 Published 1986 Journal Am. J. Physiol. Section Abstract Doc Link 3511733 Disease Relevance 0 Pain Relevance 0.10
Antidipsogenic effect of clonidine on angiotensin II-, hypertonic saline-, pilocarpine- and dehydration-induced water intakes.
Regulation (effect) of angiotensin II associated with volume depletion and dehydration and clonidine
19) Confidence 0.45 Published 1981 Journal Brain Res. Bull. Section Title Doc Link 7326582 Disease Relevance 0.35 Pain Relevance 0.38
Responses to angiotensin II were not significantly affected by ketanserin.
Neg (not) Regulation (affected) of angiotensin II
20) Confidence 0.45 Published 1984 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 6086191 Disease Relevance 0.23 Pain Relevance 0.13

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