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Context Info
Confidence 0.12
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.06
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (HRASLS)
Anatomy Link Frequency
anterior 2
nasal 2
HRASLS (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 10 99.80 Very High Very High Very High
Inflammation 38 99.24 Very High Very High Very High
opioid receptor 7 99.04 Very High Very High Very High
cINOD 3 93.64 High High
Inflammatory stimuli 3 80.68 Quite High
alcohol 1 78.16 Quite High
Enkephalin 1 59.20 Quite High
aspirin 8 13.12 Low Low
metalloproteinase 11 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 45 99.24 Very High Very High Very High
Nasal Polyps 24 99.06 Very High Very High Very High
Chronic Sinusitis 24 98.74 Very High Very High Very High
Uveitis 15 96.32 Very High Very High Very High
Disease 17 93.52 High High
Macular Edema 21 91.04 High High
Iritis 4 89.48 High High
Recurrence 3 77.00 Quite High
Ocular Hypertension 156 74.76 Quite High
Injury 1 69.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In search of proteins regulating the mu-opioid receptor endocytosis, we have recently established that activation of phospholipase D (PLD)2 is required for agonist-induced mu-opioid receptor endocytosis.
Positive_regulation (required) of Positive_regulation (activation) of phospholipase associated with agonist and opioid receptor
1) Confidence 0.12 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14720217 Disease Relevance 0 Pain Relevance 0.48
may stimulate the release of PGE2, and hence activate phospholipase II, enhancing the production of inflammatory eicosanoids.261 In support of an association between PGA and anterior uveitis, the inflammation appears to occur in the ipsilateral treated eye,261 improve after cessation and recur after rechallenge.256 Excessive doses may induce iritis.262 Affected subjects may have history of prior inflammation and/or incisional surgery.261 A case report256 documents an anterior uveitis rate as high as 4.9%, although no increase was found in PGA-treated subjects with anterior uveitis compared with those not on PGA treatment.259 No increase in uveitic relapse rates were found when latanoprost was compared with FCDT (P = 0.21).263 Fluorophotometry and laser-flare cell meters have failed to detect an effect of latanoprost on aqueous flare intensity.170

Herpes simplex keratitis

Positive_regulation (enhancing) of Positive_regulation (activate) of phospholipase II in anterior associated with inflammation, herpetic keratitis, uveitis, recurrence and iritis
2) Confidence 0.02 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2915861 Disease Relevance 1.72 Pain Relevance 0.23
This process is of great importance in chronic rhinosinusitis/nasal polyposis because increase of intracellular calcium may induce the activation of cytosolic phospholipase A2 leading to the production of leukotrienes and other pro-inflammatory lipid mediators again contributing to the chronic inflammatory process observed in these diseases.
Spec (may) Positive_regulation (induce) of Positive_regulation (activation) of phospholipase in nasal associated with inflammation, chronic sinusitis, nasal polyps and disease
3) Confidence 0.02 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 1.34 Pain Relevance 0.32

General Comments

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