INT115805

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.76
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 33
Disease Relevance 12.49
Pain Relevance 4.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PLD2) plasma membrane (PLD2) nucleus (PLD2)
cytoskeleton organization (PLD2)
Anatomy Link Frequency
fibroblasts 2
embryonic kidney 2
liver 1
colon 1
stomach 1
PLD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 54 99.56 Very High Very High Very High
alcohol 1 99.46 Very High Very High Very High
opioid receptor 35 99.38 Very High Very High Very High
Enkephalin 5 98.32 Very High Very High Very High
tolerance 2 97.04 Very High Very High Very High
Morphine 8 94.12 High High
Opioid 12 91.24 High High
metalloproteinase 27 82.96 Quite High
Cannabinoid receptor 4 80.56 Quite High
narcan 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Colon Cancer 891 100.00 Very High Very High Very High
Cancer 648 100.00 Very High Very High Very High
Breast Cancer 108 99.66 Very High Very High Very High
Sarcoma 27 98.72 Very High Very High Very High
Metastasis 54 95.88 Very High Very High Very High
Pathologic Processes 27 95.20 Very High Very High Very High
Familial Adenomatous Polyposis 81 62.48 Quite High
Glioma 27 5.00 Very Low Very Low Very Low
INFLAMMATION 27 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We further demonstrated that, in human embryonic kidney (HEK) 293 cells co-expressing MOR1 and PLD2, treatment with (D-Ala2, Me Phe4, Glyol5)enkephalin (DAMGO) led to an increase in PLD2 activity and an induction of receptor endocytosis, whereas morphine, which does not induce opioid receptor endocytosis, failed to activate PLD2.
Gene_expression (co-expressing) of PLD2 in embryonic kidney associated with opioid receptor, enkephalin and morphine
1) Confidence 0.76 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16539674 Disease Relevance 0 Pain Relevance 0.58
We clearly demonstrated that inhibition of PLD2-mediated phosphatidic acid formation by alcohol (1-butanol or ethanol) or overexpression of a dominant negative mutant of PLD2 prevented agonist-mediated endocytosis and resulted in a faster desensitization rate of the mu-opioid receptor after chronic (D-Ala2, Me Phe4, Glyol5)enkephalin treatment in human embryonic kidney 293 cells.
Gene_expression (overexpression) of PLD2 in embryonic kidney associated with agonist, enkephalin, opioid receptor and alcohol
2) Confidence 0.76 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14720217 Disease Relevance 0 Pain Relevance 0.64
Inhibition of PLD2 activity by over-expression of a dominant negative PLD2 (nPLD2) blocked the constitutive PLD2 activation and impaired the endocytosis of MOR1D receptors.
Gene_expression (over-expression) of PLD2
3) Confidence 0.66 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16539674 Disease Relevance 0 Pain Relevance 0.80
Inhibition of PLD2 activity by over-expression of a dominant negative PLD2 (nPLD2) blocked the constitutive PLD2 activation and impaired the endocytosis of MOR1D receptors.
Gene_expression (over-expression) of PLD2
4) Confidence 0.66 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16539674 Disease Relevance 0 Pain Relevance 0.80
Inhibition of PLD2 activity by over-expression of a dominant negative PLD2 (nPLD2) blocked the constitutive PLD2 activation and impaired the endocytosis of MOR1D receptors.
Gene_expression (over-expression) of nPLD2
5) Confidence 0.66 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16539674 Disease Relevance 0 Pain Relevance 0.80
Together, these results provide evidence that ARF6 protein regulates MOPr trafficking and signaling via PLD2 activation and hence affects the development of opioid receptor desensitization and tolerance.
Gene_expression (activation) of PLD2 associated with tolerance and opioid receptor
6) Confidence 0.65 Published 2009 Journal Cell. Signal. Section Abstract Doc Link 19666113 Disease Relevance 0 Pain Relevance 0.74
The PLD2 point mutation has been found in breast cancer cells [11], and PLD2 overexpression confers a survival signal attributed to an increase in basal mTOR activity [38].
Gene_expression (overexpression) of PLD2 associated with breast cancer
7) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.90 Pain Relevance 0
Findings from a recent study showed a significant association of PLD2 expression level with tumor size (P<0.05) and survival of patients with colorectal carcinoma (P<0.05) [10].
Gene_expression (expression) of PLD2 associated with cancer and colon cancer
8) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.99 Pain Relevance 0
Collectively, these observations indicate that expression of both PLD1 and PLD2 is enhanced in tissues of LiCl-treated mice.

?

Gene_expression (expression) of PLD2
9) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0 Pain Relevance 0
Elevated expression of PLD1 and PLD2 has been reported in colorectal cancer tissues [9]; in particular, PLD2 expression level and its association with clinicopathological features have recently been investigated in colorectal carcinoma [10].
Gene_expression (expression) of PLD2 associated with colon cancer
10) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.88 Pain Relevance 0.03
-catenin abrogated endogenous PLD1 and PLD2 protein expression, which further confirms the specificity of this pathway in regulation of PLDs.
Gene_expression (expression) of PLD2
11) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.55 Pain Relevance 0
Ewing's sarcoma fusion protein, EWS/Fli, has been reported to induce selective PLD2 expression by binding to the ETS domain of the PLD2 promoter [39].
Gene_expression (expression) of PLD2 associated with sarcoma
12) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.35 Pain Relevance 0
-catenin and TCF-4 bind to the TBEs of the PLD2 promoter and enhance PLD2 expression
Gene_expression (expression) of PLD2
13) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.41 Pain Relevance 0
Elevated expression of PLD1 and PLD2 has been reported in colorectal cancer tissues [9].
Gene_expression (expression) of PLD2 associated with colon cancer
14) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.93 Pain Relevance 0
The expression of PLD1 and PLD2 was increased over time in a comparable fashion between Wnt-treated and control cells as analyzed by Q-RT-PCR (Figure S2).
Gene_expression (expression) of PLD2
15) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0 Pain Relevance 0.03
Expression levels of PLD2 correlate significantly with tumor size and survival of patients with colorectal carcinoma [10].
Gene_expression (Expression) of PLD2 associated with cancer and colon cancer
16) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.98 Pain Relevance 0.04
Moreover, expression levels of PLD2 detected by real-time PCR using 97 colorectal carcinoma tissues were significantly correlated with tumor size and survival of patients with colorectal carcinoma; thus, it was suggested that PLD2 expression level could be a prognostic indicator in colorectal carcinoma [10].
Gene_expression (expression) of PLD2 associated with cancer and colon cancer
17) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.48 Pain Relevance 0
Moreover, depletion of PLD1 or PLD2 using siRNA abolished Wnt3a-induced ?
Gene_expression (using) of PLD2
18) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.09 Pain Relevance 0
Here, we demonstrate that PLD isozymes, PLD1 and PLD2 are direct targets and positive feedback regulators of the Wnt/?
Gene_expression (isozymes) of PLD2
19) Confidence 0.56 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920823 Disease Relevance 0.34 Pain Relevance 0
We have reported that stable overexpression of either PLD1 or PLD2 in fibroblasts causes transformation and enhancement of tumor formation [18].
Gene_expression (overexpression) of PLD2 in fibroblasts associated with cancer
20) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.70 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox