INT115806

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 19
Disease Relevance 7.12
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PLD2) plasma membrane (PLD2) nucleus (PLD2)
cytoskeleton organization (PLD2)
Anatomy Link Frequency
colon 4
fibroblasts 4
upper 2
embryonic kidney 2
liver 1
PLD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 35 99.56 Very High Very High Very High
alcohol 1 99.46 Very High Very High Very High
opioid receptor 19 96.16 Very High Very High Very High
Enkephalin 4 93.96 High High
Morphine 6 92.48 High High
Opioid 6 83.36 Quite High
Cannabinoid receptor 3 80.56 Quite High
metalloproteinase 15 64.48 Quite High
narcan 3 25.00 Low Low
cINOD 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 360 99.76 Very High Very High Very High
Breast Cancer 60 99.66 Very High Very High Very High
Colon Cancer 495 99.12 Very High Very High Very High
Metastasis 30 95.88 Very High Very High Very High
Pathologic Processes 15 95.20 Very High Very High Very High
Familial Adenomatous Polyposis 45 63.20 Quite High
Sarcoma 15 27.76 Quite Low
Glioma 15 5.00 Very Low Very Low Very Low
INFLAMMATION 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The PLD2 point mutation has been found in breast cancer cells [11], and PLD2 overexpression confers a survival signal attributed to an increase in basal mTOR activity [38].
Positive_regulation (overexpression) of Gene_expression (overexpression) of PLD2 associated with breast cancer
1) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.90 Pain Relevance 0
Inhibition of PLD2 activity by over-expression of a dominant negative PLD2 (nPLD2) blocked the constitutive PLD2 activation and impaired the endocytosis of MOR1D receptors.
Positive_regulation (over-expression) of Gene_expression (over-expression) of nPLD2
2) Confidence 0.49 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16539674 Disease Relevance 0 Pain Relevance 0.80
Inhibition of PLD2 activity by over-expression of a dominant negative PLD2 (nPLD2) blocked the constitutive PLD2 activation and impaired the endocytosis of MOR1D receptors.
Positive_regulation (over-expression) of Gene_expression (over-expression) of PLD2
3) Confidence 0.49 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16539674 Disease Relevance 0 Pain Relevance 0.80
Inhibition of PLD2 activity by over-expression of a dominant negative PLD2 (nPLD2) blocked the constitutive PLD2 activation and impaired the endocytosis of MOR1D receptors.
Positive_regulation (over-expression) of Gene_expression (over-expression) of PLD2
4) Confidence 0.49 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16539674 Disease Relevance 0 Pain Relevance 0.80
We clearly demonstrated that inhibition of PLD2-mediated phosphatidic acid formation by alcohol (1-butanol or ethanol) or overexpression of a dominant negative mutant of PLD2 prevented agonist-mediated endocytosis and resulted in a faster desensitization rate of the mu-opioid receptor after chronic (D-Ala2, Me Phe4, Glyol5)enkephalin treatment in human embryonic kidney 293 cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PLD2 in embryonic kidney associated with agonist, enkephalin, opioid receptor and alcohol
5) Confidence 0.49 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14720217 Disease Relevance 0 Pain Relevance 0.64
Elevated expression of PLD1 and PLD2 has been reported in colorectal cancer tissues [9]; in particular, PLD2 expression level and its association with clinicopathological features have recently been investigated in colorectal carcinoma [10].
Positive_regulation (Elevated) of Gene_expression (expression) of PLD2 associated with colon cancer
6) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.88 Pain Relevance 0.03
Using site-directed mutagenesis and the ChIP assay, we were able to define two functional TCF binding sites on the PLD2 promoter, suggesting that the PLD2 gene is a direct transcriptional target of ?
Positive_regulation (two) of Gene_expression (sites) of PLD2
7) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.42 Pain Relevance 0
In another study, overexpression of PLD2 resulted in transformation of fibroblasts overexpressing the epidermal growth factor receptor or c-Src [37].
Positive_regulation (overexpression) of Gene_expression (overexpression) of PLD2 in fibroblasts
8) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.83 Pain Relevance 0
-catenin/TCF-4-induced PLD2 expression.
Positive_regulation (induced) of Gene_expression (expression) of PLD2
9) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.45 Pain Relevance 0
The expression of PLD1 and PLD2 was increased over time in a comparable fashion between Wnt-treated and control cells as analyzed by Q-RT-PCR (Figure S2).
Positive_regulation (increased) of Gene_expression (expression) of PLD2
10) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0 Pain Relevance 0.03
Collectively, these observations indicate that expression of both PLD1 and PLD2 is enhanced in tissues of LiCl-treated mice.

?

Positive_regulation (enhanced) of Gene_expression (expression) of PLD2
11) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0 Pain Relevance 0
Using site-directed mutagenesis and the ChIP assay, we were able to define two functional TCF binding sites on the PLD2 promoter, suggesting that the PLD2 gene is a direct transcriptional target of ?
Positive_regulation (functional) of Gene_expression (sites) of PLD2
12) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.42 Pain Relevance 0
-catenin and TCF-4 bind to the TBEs of the PLD2 promoter and enhance PLD2 expression
Positive_regulation (-) of Gene_expression (expression) of PLD2
13) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.41 Pain Relevance 0
Elevated expression of PLD1 and PLD2 has been reported in colorectal cancer tissues [9].
Positive_regulation (Elevated) of Gene_expression (expression) of PLD2 associated with colon cancer
14) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.93 Pain Relevance 0
We have reported that stable overexpression of either PLD1 or PLD2 in fibroblasts causes transformation and enhancement of tumor formation [18].
Positive_regulation (overexpression) of Gene_expression (overexpression) of PLD2 in fibroblasts associated with cancer
15) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.70 Pain Relevance 0
As determined by immunoprecipitation and Western blot, expression of both PLD1 and PLD2 was enhanced in a time-dependent manner following exposure to purified recombinant Wnt3a (150 ng/ml) (Figure 1A, upper panel).
Positive_regulation (enhanced) of Gene_expression (expression) of PLD2 in upper
16) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.15 Pain Relevance 0
As analyzed by immunoprecipitation and immunoblot, LiCl increased protein levels of both PLD1 and PLD2 in colon, stomach, and liver tissues (Figure 2A).
Positive_regulation (increased) of Gene_expression (levels) of PLD2 in colon
17) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.34 Pain Relevance 0
As analyzed by immunoprecipitation and immunoblot, LiCl increased protein levels of both PLD1 and PLD2 in colon, stomach, and liver tissues (Figure 2A).
Positive_regulation (increased) of in liver Gene_expression (levels) of PLD2 in colon
18) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.34 Pain Relevance 0
As analyzed by immunoprecipitation and immunoblot, LiCl increased protein levels of both PLD1 and PLD2 in colon, stomach, and liver tissues (Figure 2A).
Positive_regulation (increased) of in stomach Gene_expression (levels) of PLD2 in colon
19) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.34 Pain Relevance 0

General Comments

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