INT115807

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.69
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PLD2) plasma membrane (PLD2) nucleus (PLD2)
cytoskeleton organization (PLD2)
PLD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 13 98.08 Very High Very High Very High
Enkephalin 2 97.68 Very High Very High Very High
opioid receptor 11 97.24 Very High Very High Very High
Morphine 2 93.04 High High
alcohol 1 88.08 High High
Opioid 2 78.32 Quite High
Cannabinoid receptor 1 75.52 Quite High
metalloproteinase 3 43.96 Quite Low
narcan 1 25.00 Low Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 12 87.96 High High
Colon Cancer 99 86.88 High High
Cancer 72 82.88 Quite High
Metastasis 6 46.24 Quite Low
Familial Adenomatous Polyposis 9 5.00 Very Low Very Low Very Low
Sarcoma 3 5.00 Very Low Very Low Very Low
Pathologic Processes 3 5.00 Very Low Very Low Very Low
Glioma 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, inhibition of PLD2 activity led to an impairment of the resensitization rate of the mu-opioid receptor.
Negative_regulation (inhibition) of PLD2 associated with opioid receptor
1) Confidence 0.57 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14720217 Disease Relevance 0 Pain Relevance 0.64
Inhibition of PLD2 activity by over-expression of a dominant negative PLD2 (nPLD2) blocked the constitutive PLD2 activation and impaired the endocytosis of MOR1D receptors.
Negative_regulation (Inhibition) of PLD2
2) Confidence 0.42 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16539674 Disease Relevance 0 Pain Relevance 0.80
PLD1 and PLD2 selective inhibitors were purchased from Cayman chemical.
Negative_regulation (inhibitors) of PLD2
3) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.55 Pain Relevance 0
Pretreatment with PLD1 or PLD2 selective inhibitor also decreased Wnt3a-induced ?
Negative_regulation (inhibitor) of PLD2
4) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.05 Pain Relevance 0
Moreover, depletion of PLD1 or PLD2 using siRNA abolished Wnt3a-induced ?
Negative_regulation (depletion) of PLD2
5) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.09 Pain Relevance 0

General Comments

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