INT115810

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.27
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transporter activity (Slc22a8) plasma membrane (Slc22a8)
Slc22a8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 8 99.34 Very High Very High Very High
methotrexate 13 94.36 High High
Desipramine 1 94.28 High High
Clonidine 1 91.16 High High
addiction 1 57.40 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Corticosterone and 17beta-estradiol, known inhibitors of organic cation transporter 3 (OCT3), did not cause any significant inhibition.
Negative_regulation (inhibitors) of OCT3
1) Confidence 0.41 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16000150 Disease Relevance 0 Pain Relevance 0.17
Other inhibitors of rOatps (taurocholate and pravastatin) and rOat3 (pravastatin and p-aminohippurate) had a slight effect, but digoxin had no effect.
Negative_regulation (inhibitors) of rOat3
2) Confidence 0.23 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 15900017 Disease Relevance 0.13 Pain Relevance 0.13
NSAIDs, except salicylate, were potent inhibitors of rOat3 (K(i) of 1.3-19 microM), but weak inhibitors of RFC-1 (K(i) of 70-310 microM).
Negative_regulation (inhibitors) of rOat3 associated with cinod
3) Confidence 0.11 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14722319 Disease Relevance 0.14 Pain Relevance 0.88

General Comments

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