INT115812

Context Info Confidence 0.08 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.17 Pain Relevance 0.65

transmembrane transporter activity (Slc22a8) plasma membrane (Slc22a8)

Slc22a8 (Rattus norvegicus) Mtx1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat methotrexate 13 100.00 cINOD 6 98.48

Disease Link Frequency Relevance Heat INFLAMMATION 2 97.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

MTX is recognized by reduced folate carrier (RFC-1) and rat organic anion transporters (rOat1 and rOat3) as a substrate.

rOat3 Binding (recognized) of MTX associated with methotrexate

1) Confidence 0.08 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14722319 Disease Relevance 0.17 Pain Relevance 0.65

General Comments

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