INT115816

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Context Info
Confidence 0.99
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 35
Total Number 35
Disease Relevance 20.14
Pain Relevance 5.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (APP) extracellular matrix organization (APP) DNA binding (APP)
cytoplasm (APP) cytosol (APP) extracellular region (APP)
Anatomy Link Frequency
cleavage 13
APP (Homo sapiens)
APP - T668A (1)
Pain Link Frequency Relevance Heat
Abeta 76 100.00 Very High Very High Very High
metalloproteinase 14 99.44 Very High Very High Very High
cINOD 138 99.14 Very High Very High Very High
aspirin 95 91.32 High High
agonist 1 87.44 High High
Central nervous system 30 86.60 High High
Inflammation 62 83.80 Quite High
cytokine 9 79.56 Quite High
nMDA receptor antagonist 6 77.76 Quite High
cva 2 68.56 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 469 100.00 Very High Very High Very High
Disease 727 99.96 Very High Very High Very High
Asthma 177 99.72 Very High Very High Very High
Aging 123 99.64 Very High Very High Very High
Amyloid Plaque 260 99.24 Very High Very High Very High
Cognitive Disorder 79 98.52 Very High Very High Very High
INFLAMMATION 79 96.84 Very High Very High Very High
Heart Disease 2 95.60 Very High Very High Very High
Drug Induced Neurotoxicity 16 92.40 High High
Neurodegenerative Disease 26 92.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-secretase cleavage of APP, were assessed in 188 patients with MCI or mild to moderate AD.
Protein_catabolism (cleavage) of APP in cleavage associated with cognitive disorder and disease
1) Confidence 0.99 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2945639 Disease Relevance 0.83 Pain Relevance 0
However, this seems less likely because proteolysis of APP(T668A) mutant and SP-C99(T668A) mutants was still promoted by H2O2 in our study (Fig. 5).
Protein_catabolism (proteolysis) of APP (T668A) associated with amyloid plaque
2) Confidence 0.95 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.19 Pain Relevance 0.04
If APP is proteolytically cleaved by the enzyme ?
Protein_catabolism (cleaved) of APP
3) Confidence 0.95 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656296 Disease Relevance 0.48 Pain Relevance 0
These results, suggesting that drugs modulate the ability of cell-derived factors to degrade Abeta, was interrogated by adding protease inhibitors and performing molecular weight cut-off fractionation.
Protein_catabolism (degrade) of Abeta associated with abeta
4) Confidence 0.87 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19702658 Disease Relevance 0.40 Pain Relevance 0.88
Selective modulation of amyloid-beta peptide degradation by flurbiprofen, fenofibrate, and related compounds regulates Abeta levels.
Protein_catabolism (degradation) of amyloid-beta associated with alzheimer's dementia and abeta
5) Confidence 0.87 Published 2009 Journal J. Neurochem. Section Title Doc Link 19702658 Disease Relevance 0.53 Pain Relevance 0.65
Briefly, certain conditions or triggers (eg, genetic influences, aging, etc) predispose APP proteolysis to produce more A?
Protein_catabolism (proteolysis) of APP associated with aging
6) Confidence 0.82 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656296 Disease Relevance 0.49 Pain Relevance 0
Apparently, NSAID has differential affects on the selective cleavage of APP-CTFs by the ?
Protein_catabolism (cleavage) of APP in cleavage associated with cinod
7) Confidence 0.82 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0 Pain Relevance 0.10
Finally, increased degradation of sAPP in neuroinflammation remains a vital possibility.
Protein_catabolism (degradation) of sAPP
8) Confidence 0.78 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2902447 Disease Relevance 0.35 Pain Relevance 0
-secretase-mediated APP cleavage, HEK293T cells were transiently transfected with mammalian expression plasmids encoding wild type APP695myc or APP(T668A)myc, in which Thr668 has been replaced by Ala668.
Protein_catabolism (cleavage) of APP in cleavage
9) Confidence 0.74 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.14 Pain Relevance 0
Stimulation of the expression or activity of alpha-secretase or neprilysin has been shown to enhance Abeta degradation.
Protein_catabolism (degradation) of Abeta associated with abeta
10) Confidence 0.73 Published 2006 Journal Drugs Section Abstract Doc Link 17112302 Disease Relevance 0.58 Pain Relevance 0.58
Selective modulation of amyloid-beta peptide degradation by flurbiprofen, fenofibrate, and related compounds regulates Abeta levels.
Protein_catabolism (degradation) of Abeta associated with alzheimer's dementia and abeta
11) Confidence 0.66 Published 2009 Journal J. Neurochem. Section Title Doc Link 19702658 Disease Relevance 0.54 Pain Relevance 0.69
Platelet phagocytosis, resulting in macrophage activation and iNOS induction, was associated with the formation of amyloid-beta peptide (Abeta) via proteolytic cleavage of platelet-derived amyloid precursor protein (APP), possibly by secretases.
Protein_catabolism (cleavage) of APP in cleavage associated with alzheimer's dementia and abeta
12) Confidence 0.66 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15076232 Disease Relevance 0.53 Pain Relevance 0.36
According to this hypothesis, both cholesterol and the examined compounds stimulated the beta-secretase cleavage of APP, resulting in a massive increase of secreted amyloid-beta peptides.
Protein_catabolism (cleavage) of APP in cleavage associated with alzheimer's dementia
13) Confidence 0.64 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17395689 Disease Relevance 0.57 Pain Relevance 0.10
42 compared to wt PS1, and differential proteolytic cleavages of its two studied substrates by increasing cleavage of APP after residue 42 (yielding A?
Protein_catabolism (cleavage) of APP in cleavage
14) Confidence 0.63 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0 Pain Relevance 0
The APP processing is a sequential proteolysis that is carried out by ?
Protein_catabolism (proteolysis) of APP
15) Confidence 0.63 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.99 Pain Relevance 0
Because the proteolysis of APP by ?
Protein_catabolism (proteolysis) of APP
16) Confidence 0.63 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.63 Pain Relevance 0
As was described in a previous section, sequential cleavage of APP by ?
Protein_catabolism (cleavage) of APP in cleavage
17) Confidence 0.62 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656296 Disease Relevance 0.58 Pain Relevance 0.04
Specifically, APP proteolysis following internalization occurs in:
Protein_catabolism (proteolysis) of APP
18) Confidence 0.62 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656296 Disease Relevance 0.16 Pain Relevance 0
The proteolysis of APP by ?
Protein_catabolism (proteolysis) of APP
19) Confidence 0.62 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656296 Disease Relevance 0.17 Pain Relevance 0
There has been a report that APP is cleaved by ?
Protein_catabolism (cleaved) of APP
20) Confidence 0.60 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2896935 Disease Relevance 0.84 Pain Relevance 0.27

General Comments

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