INT115826

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Context Info
Confidence 0.52
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.15
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Cyp1a1) mitochondrion (Cyp1a1) oxidoreductase activity (Cyp1a1)
aging (Cyp1a1) endoplasmic reticulum (Cyp1a1) enzyme binding (Cyp1a1)
Cyp1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 2 83.64 Quite High
anesthesia 2 77.96 Quite High
cINOD 4 71.20 Quite High
Inflammation 29 63.00 Quite High
Glutamate 2 56.00 Quite High
chemokine 4 21.92 Low Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 3 94.68 High High
Cancer 34 94.32 High High
Toxicity 4 89.36 High High
Liver Cancer 2 85.60 High High
Injury 5 77.28 Quite High
Stress 2 76.68 Quite High
Poisoning 1 65.96 Quite High
Hepatotoxicity 2 65.00 Quite High
INFLAMMATION 30 63.00 Quite High
Cirrhosis 1 47.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FFx increased the mRNA level of CYP1A1; an increase that was not prevented by GdCl3.
Transcription (level) of CYP1A1
1) Confidence 0.52 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 14723344 Disease Relevance 0.48 Pain Relevance 0.08
Sulindac induced the transcription of the CYP1A1 gene, as measured by the level of heterogeneous nuclear 1A1 RNA and by actinomycin D chase experiment.
Transcription (transcription) of CYP1A1
2) Confidence 0.35 Published 2006 Journal Carcinogenesis Section Abstract Doc Link 16531450 Disease Relevance 0.15 Pain Relevance 0.16
Since the transcription of CYP1A1 is under the control of the aryl hydrocarbon receptor (AhR), we examined the ability of sulindac to activate the receptor.
Transcription (transcription) of CYP1A1
3) Confidence 0.35 Published 2006 Journal Carcinogenesis Section Abstract Doc Link 16531450 Disease Relevance 0.14 Pain Relevance 0.16
, we analyzed CYP1A1, GST and AhRR (AhR repressor) mRNA expression as functional markers of AhR [8-11,29].
Spec (analyzed) Transcription (expression) of CYP1A1
4) Confidence 0.25 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0 Pain Relevance 0
Andrographolide significantly induced the expression of CYP1A1 and CYP1A2 mRNAs in a concentration-dependent manner, and synergistically induced CYP1A1 expression with the typical CYP1A inducers [95,96].
Transcription (expression) of CYP1A1
5) Confidence 0.15 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 0.38 Pain Relevance 0.14

General Comments

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