INT115835

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Context Info
Confidence 0.32
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.35
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Cyp1a1) mitochondrion (Cyp1a1) oxidoreductase activity (Cyp1a1)
aging (Cyp1a1) endoplasmic reticulum (Cyp1a1) enzyme binding (Cyp1a1)
Anatomy Link Frequency
MCF-7 2
Cyp1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 6 96.48 Very High Very High Very High
anesthesia 1 78.72 Quite High
cINOD 1 59.76 Quite High
COX2 1 25.00 Low Low
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 4 97.28 Very High Very High Very High
Necrosis 2 95.44 Very High Very High Very High
Breast Cancer 5 93.88 High High
Injury 4 78.04 Quite High
Death 1 78.00 Quite High
Apoptosis 1 76.32 Quite High
INFLAMMATION 1 59.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FFx increased the mRNA level of CYP1A1; an increase that was not prevented by GdCl3.
Negative_regulation (prevented) of Positive_regulation (increased) of CYP1A1
1) Confidence 0.32 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 14723344 Disease Relevance 0.49 Pain Relevance 0.08
CYP1A was undetectable in RMTCs while CYP1A induction by beta-naphthoflavone in MCF-7 cells was significantly inhibited by SA in a concentration-dependent manner.
Negative_regulation (inhibited) of Positive_regulation (induction) of CYP1A in MCF-7
2) Confidence 0.13 Published 2006 Journal Int. J. Oncol. Section Abstract Doc Link 16596229 Disease Relevance 0.87 Pain Relevance 0.28

General Comments

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