INT115845

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Context Info
Confidence 0.40
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.58
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DNASE1L3) DNA binding (DNASE1L3) DNA metabolic process (DNASE1L3)
Anatomy Link Frequency
HeLa 2
DNASE1L3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 12 98.84 Very High Very High Very High
Triptan 14 5.00 Very Low Very Low Very Low
ergotamine 8 5.00 Very Low Very Low Very Low
Serotonin 8 5.00 Very Low Very Low Very Low
monoamine 5 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Sumatriptan 5 5.00 Very Low Very Low Very Low
sSRI 4 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Migraine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1 90.96 High High
Apoptosis 5 85.00 Quite High
Death 2 81.60 Quite High
Reprotox - General 1 1 71.96 Quite High
Adenocarcinoma 1 64.00 Quite High
Hepatocellular Cancer 1 45.80 Quite Low
Cluster Headache 10 5.00 Very Low Very Low Very Low
Poisoning 4 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low
Drug Dependence 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The treatment of HeLa cells with acetaminophen resulted in internuclesomal DNA fragmentation only after transfection of these cells with a plasmid encoding the DNAS1L3 gene suggesting that this endonuclease is required for acetaminophen-induced internucleosomal DNA fragmentation.
Positive_regulation (transfection) of Gene_expression (transfection) of DNAS1L3 in HeLa associated with paracetamol
1) Confidence 0.40 Published 2004 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 14725611 Disease Relevance 0.58 Pain Relevance 0.90
Furthermore, almost nothing is known regarding the contribution of specific drug-metabolizing enzyme to the production of individual LSD metabolites in humans.
Positive_regulation (metabolizing) of Gene_expression (production) of LSD
2) Confidence 0.16 Published 2008 Journal AAPS J Section Body Doc Link PMC2751378 Disease Relevance 0 Pain Relevance 0

General Comments

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