INT115850

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Context Info
Confidence 0.73
First Reported 2004
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.68
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Mtap2) intracellular (Mtap2) protein complex (Mtap2)
cytoplasm (Mtap2)
Anatomy Link Frequency
neurons 3
dendrite 1
neuronal 1
Mtap2 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 39 98.66 Very High Very High Very High
Spinal cord 9 98.64 Very High Very High Very High
Dorsal horn 3 97.88 Very High Very High Very High
Morphine 64 92.84 High High
tolerance 5 90.44 High High
ischemia 36 89.32 High High
Antinociceptive 1 88.52 High High
medulla 1 85.32 High High
GABAergic 41 85.08 High High
midbrain 4 84.64 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 175 99.28 Very High Very High Very High
Sprains And Strains 73 99.12 Very High Very High Very High
Disease 211 97.96 Very High Very High Very High
Cv General 4 Under Development 11 89.32 High High
Death 26 86.68 High High
Alzheimer's Dementia 52 85.36 High High
Amyloid Plaque 20 84.40 Quite High
Hypertrophy 2 75.00 Quite High
Infection 38 74.24 Quite High
Disease Progression 4 71.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The differences in abundance of Gfap and Mtap2 observed between the strains are likely to be restricted to specific mRNA forms, represented on the array by the 1440142_s_at and 1440699_at probe-sets (Figure 4).
Localization (abundance) of Mtap2 associated with sprains and strains
1) Confidence 0.73 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.49 Pain Relevance 0.20
Free-floating sections were washed in 0.05 M PBS with 0.02% triton X (PBS-Tx), blocked for 1 hour in 10% normal goat serum (PBS-Tx), and incubated overnight in anti-MAP2 (1?
Neg (blocked) Localization (blocked) of MAP2
2) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 0 Pain Relevance 0.17
Virtually all astroglia-derived neurosphere cells transduced with Neurog2 differentiated into MAP2-positive neurons (91.4%±2.2%, n?
Localization (differentiated) of MAP2 in neurons
3) Confidence 0.40 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.19 Pain Relevance 0.15
While further studies are required, the co-localization of BACE1 immunoreactivity with synaptophysin, but not MAP2, suggested a presynaptic localization for BACE1.
Localization (localization) of MAP2
4) Confidence 0.29 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.82 Pain Relevance 0
While further studies are required, the co-localization of BACE1 immunoreactivity with synaptophysin, but not MAP2, suggested a presynaptic localization for BACE1.
Localization (localization) of MAP2
5) Confidence 0.27 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.58 Pain Relevance 0
The present study clearly showed that MHCI molecules are expressed on MAP-2 positive neurons of V1.
Localization (neurons) of MAP-2 in neurons
6) Confidence 0.20 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
The PKCgamma-IR was exclusively colocalized with the neuron-specific markers neuronal nuclei (NeuN) and microtubule associated protein 2ab (MAP2ab).
Localization (colocalized) of microtubule associated protein 2ab in neuronal
7) Confidence 0.18 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 14725643 Disease Relevance 0.21 Pain Relevance 0.94
Interestingly, analysis of MAP2 staining showed in some cases higher colocalization of MAP2 and GFP in the control neurons compared to the Ran RNAi neurons in the explant cultures (Figure 5H left and right panels).
Localization (colocalization) of MAP2 in neurons
8) Confidence 0.14 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2435276 Disease Relevance 0 Pain Relevance 0
Fractions of GFP+c-Kit+ cells colocalizing with specific markers MAP-2, GFAP, Neu-N, and Musashi-1 in the EPO+G-CSF-treated mice (?
Localization (colocalizing) of MAP-2
9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852409 Disease Relevance 0.23 Pain Relevance 0.12
m2/field) in the CA1 stratum radiatum dendrite region from three hippocampus sections from three Glud1 and three wt mice, revealed significant decreases in MAP2A labelling in the Tg mice (MAP2A = 26.51 ± 2.56, mean ± SEM, for Glud1; 37.83 ± 1.31, for wt mice; P = 0.029, One-way ANOVA, pair-wise comparisons Student-Newman-Keuls).
Localization (decreases) of MAP2A in dendrite associated with targeted disruption and hippocampus
10) Confidence 0.05 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.15 Pain Relevance 0.19

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