INT115852

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Context Info
Confidence 0.71
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 2.23
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv4) plasma membrane (Trpv4) cilium (Trpv4)
transmembrane transport (Trpv4)
Anatomy Link Frequency
ganglia 2
gut 2
cilia 1
bladders 1
kidney 1
Trpv4 (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 1 98.72 Very High Very High Very High
dorsal root ganglion 46 98.08 Very High Very High Very High
trigeminal ganglion 3 96.88 Very High Very High Very High
imagery 13 93.84 High High
TRP channel 78 93.56 High High
agonist 30 89.92 High High
qutenza 26 89.24 High High
Spinal cord 8 88.00 High High
spinal dorsal horn 19 87.44 High High
calcitonin gene related peptide 3 85.04 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 56 98.08 Very High Very High Very High
Targeted Disruption 42 96.36 Very High Very High Very High
Stress 6 90.00 High High
Helminth Infection 1 88.60 High High
Overactive Bladder 45 80.52 Quite High
Stress Incontinence 3 79.84 Quite High
Nociception 8 63.72 Quite High
Pressure And Volume Under Development 16 49.52 Quite Low
Polycystic Kidney Disease 7 44.80 Quite Low
Neuropathic Pain 2 36.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative polymerase chain reaction showed very low levels of TRPA1 and TRPV1 mRNA but high levels of TRPV4 and TRPV2 mRNA.
Transcription (levels) of TRPV4
1) Confidence 0.71 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.25 Pain Relevance 0.13
Recently, TRPV4 was found in cilia in cholangiocytes and the oviduct (Teilmann et al., 2005; Gradilone et al., 2007).
Transcription (found) of TRPV4 in cilia
2) Confidence 0.68 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.18 Pain Relevance 0.11
We have also found that TRPV4-mediated channel activity induced by 4?
Transcription (found) of TRPV4
3) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2650694 Disease Relevance 0.45 Pain Relevance 0.64
In addition TRPV4 transcripts were found at high levels in these two organs.
Transcription (found) of TRPV4
4) Confidence 0.55 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.03
In addition, RT-PCR of single nodose cell bodies, which had been retrogradely labeled from the upper gut, detected transcripts for TRPV1, TRPV2, TRPV4, TRPN1, and TRPM8 in a proportion of cells.
Transcription (detected) of TRPV4 in gut
5) Confidence 0.53 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 14726308 Disease Relevance 0.16 Pain Relevance 0.35
In the same paper, it is reported that TRPV4 mRNA was detected in urinary bladder smooth muscle and urothelium of mouse bladders but was absent in TRPV4 knockout bladders.
Neg (absent) Transcription (detected) of TRPV4 in bladders associated with targeted disruption
6) Confidence 0.53 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.52 Pain Relevance 0.27
Quantitative polymerase chain reaction showed very low levels of TRPA1 and TRPV1 mRNA but high levels of TRPV4 and TRPV2 mRNA.
Transcription (levels) of TRPV4
7) Confidence 0.53 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.24 Pain Relevance 0.13
TRPV1, TRPV2, TRPV3 and TRPV4 mRNAs were expressed in spiral and vestibular ganglia, and TRPV2 and TRPV1 mRNAs were most predominant in control mice.
Transcription (expressed) of TRPV4 in ganglia
8) Confidence 0.52 Published 2005 Journal Hear. Res. Section Abstract Doc Link 15721568 Disease Relevance 0.08 Pain Relevance 0.23
Real-time PCR also demonstrated a significant down-regulation in TRPV4 mRNA expression in the inner ear ganglia and kidney after KM treatment.
Transcription (expression) of TRPV4 in kidney
9) Confidence 0.52 Published 2005 Journal Hear. Res. Section Abstract Doc Link 15721568 Disease Relevance 0.10 Pain Relevance 0.22
In addition, RT-PCR of single nodose cell bodies, which had been retrogradely labeled from the upper gut, detected transcripts for TRPV1, TRPV2, TRPV4, TRPN1, and TRPM8 in a proportion of cells.
Transcription (transcripts) of TRPV4 in gut
10) Confidence 0.40 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 14726308 Disease Relevance 0.16 Pain Relevance 0.34
Real-time PCR also demonstrated a significant down-regulation in TRPV4 mRNA expression in the inner ear ganglia and kidney after KM treatment.
Transcription (expression) of TRPV4 in ganglia
11) Confidence 0.18 Published 2005 Journal Hear. Res. Section Abstract Doc Link 15721568 Disease Relevance 0.10 Pain Relevance 0.22

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