INT115854

Context Info Confidence 0.53 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 5 Disease Relevance 0.89 Pain Relevance 1.18

transport (Trpv2) plasma membrane (Trpv2) intracellular (Trpv2) transmembrane transport (Trpv2) cytoplasm (Trpv2)

Anatomy Link Frequency gut 2 ganglia 1 Trpv2 (Mus musculus)

Pain Link Frequency Relevance Heat imagery 4 94.64 TRP channel 12 93.56 agonist 19 89.92 qutenza 12 89.24 trigeminal ganglion 1 76.88 member 8 2 76.08 antagonist 22 5.00 Lasting pain 2 5.00 anesthesia 2 5.00 Dopamine 2 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 22 90.56 Ganglion Cysts 6 82.32 Overactive Bladder 30 80.52 Benign Prostatic Hypertrophy 2 8.48 Fever 4 5.00 Pressure And Volume Under Development 4 5.00 Hyperalgesia 2 5.00 Stress 2 5.00 Incontinence 2 5.00 Urinary Dysfunction 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, RT-PCR of single nodose cell bodies, which had been retrogradely labeled from the upper gut, detected transcripts for TRPV1, TRPV2, TRPV4, TRPN1, and TRPM8 in a proportion of cells.

Transcription (detected) of TRPV2 in gut

1) Confidence 0.53 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 14726308 Disease Relevance 0.16 Pain Relevance 0.34

TRPV1, TRPV2, TRPV3 and TRPV4 mRNAs were expressed in spiral and vestibular ganglia, and TRPV2 and TRPV1 mRNAs were most predominant in control mice.

Transcription (expressed) of TRPV2 in ganglia

2) Confidence 0.51 Published 2005 Journal Hear. Res. Section Abstract Doc Link 15721568 Disease Relevance 0.08 Pain Relevance 0.23

In addition, RT-PCR of single nodose cell bodies, which had been retrogradely labeled from the upper gut, detected transcripts for TRPV1, TRPV2, TRPV4, TRPN1, and TRPM8 in a proportion of cells.

Transcription (transcripts) of TRPV2 in gut

3) Confidence 0.39 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 14726308 Disease Relevance 0.16 Pain Relevance 0.34

Quantitative polymerase chain reaction showed very low levels of TRPA1 and TRPV1 mRNA but high levels of TRPV4 and TRPV2 mRNA.

Transcription (levels) of TRPV2

4) Confidence 0.38 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.25 Pain Relevance 0.13

Quantitative polymerase chain reaction showed very low levels of TRPA1 and TRPV1 mRNA but high levels of TRPV4 and TRPV2 mRNA.

Transcription (levels) of TRPV2

5) Confidence 0.28 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.24 Pain Relevance 0.13

General Comments

This test has worked.