INT115861

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.45
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PRSS3) extracellular space (PRSS3) extracellular region (PRSS3)
Anatomy Link Frequency
colon 1
PRSS3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 4 99.40 Very High Very High Very High
agonist 5 96.68 Very High Very High Very High
spastic colon 14 95.08 Very High Very High Very High
Pain 1 82.48 Quite High
Inflammation 1 82.24 Quite High
Hyperalgesia 1 78.96 Quite High
nud 2 73.12 Quite High
Disease Link Frequency Relevance Heat
Diarrhoea 1 96.68 Very High Very High Very High
Constipation 1 96.12 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

11 95.08 Very High Very High Very High
Functional Bowel Disorder 3 87.76 High High
Congenital Anomalies 1 84.16 Quite High
Pain 1 82.48 Quite High
INFLAMMATION 1 82.24 Quite High
Hyperalgesia 1 78.96 Quite High
Dyspepsia 2 73.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Epithelial cells lines from prostate, colon, and airway and human colonic mucosa expressed mRNA encoding PAR(2), trypsinogen IV, and enteropeptidase, which activates the zymogen.
Transcription (expressed) of trypsinogen IV in colon
1) Confidence 0.67 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14726524 Disease Relevance 0.16 Pain Relevance 0.25
Gene transcripts of PAR-2, trypsinogen IV, TPH-1, SERT (serotonin transport protein) and serotonin (5-HT(3)) subunits were quantified using real-time PCR and 5-HT content was measured by ELISA.
Transcription (transcripts) of trypsinogen IV associated with serotonin
2) Confidence 0.03 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18363639 Disease Relevance 0.67 Pain Relevance 1.14

General Comments

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