INT11587

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Context Info
Confidence 0.78
First Reported 1983
Last Reported 2011
Negated 45
Speculated 7
Reported most in Abstract
Documents 645
Total Number 652
Disease Relevance 544.38
Pain Relevance 93.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CSF2) extracellular region (CSF2)
Anatomy Link Frequency
CSF 53
blood 36
macrophage 34
plasma 28
granulocyte 15
CSF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 3227 100.00 Very High Very High Very High
cytokine 2498 100.00 Very High Very High Very High
Multiple sclerosis 1991 100.00 Very High Very High Very High
chemokine 1164 100.00 Very High Very High Very High
intrathecal 889 100.00 Very High Very High Very High
metalloproteinase 605 100.00 Very High Very High Very High
5HT 305 100.00 Very High Very High Very High
addiction 20 100.00 Very High Very High Very High
Dismenorea 19 100.00 Very High Very High Very High
Pain 627 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 8596 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 7517 100.00 Very High Very High Very High
Cancer 4369 100.00 Very High Very High Very High
INFLAMMATION 3478 100.00 Very High Very High Very High
Demyelinating Disease 2191 100.00 Very High Very High Very High
Leukocytosis 2014 100.00 Very High Very High Very High
Neuromyelitis Optica 1988 100.00 Very High Very High Very High
Cold Sores 1906 100.00 Very High Very High Very High
Carcinoma 460 100.00 Very High Very High Very High
Mycobacterial Infection 302 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bacterially synthesized human granulocyte colony-stimulating factor (G-CSF) and granulocyte macrophage colony-stimulating factor (GM-CSF) have been studied to determine if they could prevent or reduce the neutropenia caused by chemotherapy.
Gene_expression (synthesized) of granulocyte macrophage colony-stimulating factor in granulocyte associated with neutropenia
1) Confidence 0.78 Published 1989 Journal Semin. Hematol. Section Abstract Doc Link 2471275 Disease Relevance 0.30 Pain Relevance 0.07
Bacterially synthesized human granulocyte colony-stimulating factor (G-CSF) and granulocyte macrophage colony-stimulating factor (GM-CSF) have been studied to determine if they could prevent or reduce the neutropenia caused by chemotherapy.
Gene_expression (synthesized) of granulocyte colony-stimulating factor in granulocyte associated with neutropenia
2) Confidence 0.78 Published 1989 Journal Semin. Hematol. Section Abstract Doc Link 2471275 Disease Relevance 0.28 Pain Relevance 0.06
Phase I study of intravenously administered bacterially synthesized granulocyte-macrophage colony-stimulating factor and comparison with subcutaneous administration.
Gene_expression (synthesized) of granulocyte-macrophage colony-stimulating factor in macrophage
3) Confidence 0.78 Published 1990 Journal Cancer Res. Section Title Doc Link 2404573 Disease Relevance 0.31 Pain Relevance 0
CSF is produced mainly by the choroid plexus in the brain ventricles with a daily production rate of about 500 ml in humans [13].
Gene_expression (produced) of CSF in brain ventricles
4) Confidence 0.78 Published 2010 Journal J Pharmacokinet Pharmacodyn Section Body Doc Link PMC3005107 Disease Relevance 0.09 Pain Relevance 0.12
Yeast-expressed granulocyte-macrophage colony-stimulating factor in cancer patients: a phase ib clinical study.
Gene_expression (expressed) of granulocyte-macrophage colony-stimulating factor in macrophage associated with cancer
5) Confidence 0.77 Published 1988 Journal Behring Inst. Mitt. Section Title Doc Link 2467645 Disease Relevance 0.58 Pain Relevance 0.05
Probably the only true non-obstructive types of hydrocephalus are venous sinus thrombosis, and choroid plexus papilloma leading to CSF overproduction.
Gene_expression (overproduction) of CSF in choroid plexus associated with intracranial sinus thrombosis, choroid plexus papilloma and hydrocephalus
6) Confidence 0.76 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2615740 Disease Relevance 1.45 Pain Relevance 0.14
We report a case of pancreatic ductal adenocarcinoma producing granulocyte-colony stimulating factor (G-CSF).
Gene_expression (producing) of G-CSF in granulocyte associated with adenocarcinoma
7) Confidence 0.74 Published 2007 Journal Nippon Shokakibyo Gakkai Zasshi Section Abstract Doc Link 17283419 Disease Relevance 0.58 Pain Relevance 0.09
There was no correlation between Gm haplotype and CSF or serum IgG levels in patients with ON or OND.
Gene_expression (levels) of CSF in CSF associated with neurological disease and neuritis
8) Confidence 0.74 Published 1984 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 6713741 Disease Relevance 1.21 Pain Relevance 0.57
Moreover, GM-CSF is expressed at high levels in those regions of the gastrointestinal tract that are associated with the greatest concentration of luminal microbial colonization.
Gene_expression (expressed) of GM-CSF
9) Confidence 0.70 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621411 Disease Relevance 0.65 Pain Relevance 0.08
The available data have suggested that GM-CSF is associated with a more wide and potent action on multiple cells, such as neutrophils, monocytes, and intestinal epithelial cells which expressed receptors for GM-CSF.
Gene_expression (expressed) of GM-CSF in epithelial cells
10) Confidence 0.70 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621411 Disease Relevance 0.46 Pain Relevance 0.08
GM-CSF is expressed by CD4+ T-cells and Paneth cells in the intestine.
Gene_expression (expressed) of GM-CSF in intestine
11) Confidence 0.70 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621411 Disease Relevance 0.79 Pain Relevance 0.08
The CSF levels of IMP, inosine, guanosine and uric acid were significantly increased in the chronic pain group and correlated with pain severity (P<0.05).
Gene_expression (levels) of CSF in CSF associated with pain and lasting pain
12) Confidence 0.70 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20211694 Disease Relevance 0.72 Pain Relevance 0.62
Bacterially synthesized human granulocyte colony-stimulating factor (G-CSF) and granulocyte macrophage colony-stimulating factor (GM-CSF) have been studied to determine if they could prevent or reduce the neutropenia caused by chemotherapy.
Gene_expression (synthesized) of GM-CSF in granulocyte associated with neutropenia
13) Confidence 0.68 Published 1989 Journal Semin. Hematol. Section Abstract Doc Link 2471275 Disease Relevance 0.30 Pain Relevance 0.07
Bacterially synthesized human granulocyte colony-stimulating factor (G-CSF) and granulocyte macrophage colony-stimulating factor (GM-CSF) have been studied to determine if they could prevent or reduce the neutropenia caused by chemotherapy.
Gene_expression (synthesized) of G-CSF in granulocyte associated with neutropenia
14) Confidence 0.68 Published 1989 Journal Semin. Hematol. Section Abstract Doc Link 2471275 Disease Relevance 0.28 Pain Relevance 0.06
Effects of bacterially synthesized recombinant human granulocyte-macrophage colony-stimulating factor in patients with advanced malignancy.
Gene_expression (synthesized) of granulocyte-macrophage colony-stimulating factor in macrophage associated with pain and malignant neoplastic disease
15) Confidence 0.68 Published 1989 Journal Ann. Intern. Med. Section Title Doc Link 2644886 Disease Relevance 0.10 Pain Relevance 0.10
STUDY OBJECTIVE: To define the clinical and hematologic effects of subcutaneously administered bacterially synthesized recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF).
Gene_expression (synthesized) of granulocyte-macrophage colony-stimulating factor in macrophage
16) Confidence 0.68 Published 1989 Journal Ann. Intern. Med. Section Abstract Doc Link 2644886 Disease Relevance 0.07 Pain Relevance 0
CONCLUSIONS: Bacterially synthesized rhGM-CSF induces a leukocytosis in the dose range of 3 to 15 micrograms/kg.d.
Gene_expression (synthesized) of rhGM-CSF
17) Confidence 0.68 Published 1989 Journal Ann. Intern. Med. Section Body Doc Link 2644886 Disease Relevance 0 Pain Relevance 0
STUDY OBJECTIVE: To define the clinical and hematologic effects of subcutaneously administered bacterially synthesized recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF).
Gene_expression (synthesized) of rhGM-CSF in macrophage
18) Confidence 0.68 Published 1989 Journal Ann. Intern. Med. Section Abstract Doc Link 2644886 Disease Relevance 0.07 Pain Relevance 0
Bacterially synthesized recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) is an agent with therapeutic potential for neutropenic states, but even at doses below the maximal tolerated dose adverse effects occur during short courses of administration.
Gene_expression (synthesized) of rhGM-CSF in macrophage
19) Confidence 0.68 Published 1989 Journal Blood Section Abstract Doc Link 2684297 Disease Relevance 0.47 Pain Relevance 0.05
Characterization of the clinical effects after the first dose of bacterially synthesized recombinant human granulocyte-macrophage colony-stimulating factor.
Gene_expression (synthesized) of colony-stimulating factor in macrophage
20) Confidence 0.68 Published 1989 Journal Blood Section Title Doc Link 2684297 Disease Relevance 0.90 Pain Relevance 0.07

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