INT115877

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Context Info
Confidence 0.59
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 14
Total Number 16
Disease Relevance 5.31
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adcyap1) extracellular space (Adcyap1) extracellular region (Adcyap1)
Anatomy Link Frequency
spinal nerve 2
pituitary 2
brain 2
middle cerebral artery 1
Adcyap1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 27 100.00 Very High Very High Very High
IPN 2 99.16 Very High Very High Very High
Substantia nigra 4 98.52 Very High Very High Very High
Glutamate 15 97.72 Very High Very High Very High
Pain 8 97.48 Very High Very High Very High
Neuropathic pain 6 96.36 Very High Very High Very High
Spinal cord 7 95.52 Very High Very High Very High
anesthesia 5 93.60 High High
Serotonin 14 93.56 High High
intrathecal 4 83.84 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Pain 2 99.16 Very High Very High Very High
Disease 23 98.04 Very High Very High Very High
Pain 4 97.48 Very High Very High Very High
Neuropathic Pain 10 96.36 Very High Very High Very High
Stroke 2 95.48 Very High Very High Very High
Middle Cerebral Artery Infarction 7 95.16 Very High Very High Very High
Nociception 4 92.84 High High
Hypothermia 2 92.08 High High
Parkinson's Disease 1 89.64 High High
Congenital Anomalies 18 88.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously observed that mice lacking the Adcyap1 gene encoding the neuropeptide PACAP (Adcyap1-/-) displayed intense jumping behavior when placed in a novel environment such as an open field.
Negative_regulation (lacking) of Adcyap1 associated with neuropeptide
1) Confidence 0.59 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 16888223 Disease Relevance 0 Pain Relevance 0.20
Mice lacking PACAP (PACAP-KO) exhibits altered psychomotor behaviors, including impaired habituation to a novel environment and perseverative jumping, with a slightly reduced levels of the serotonin metabolite, 5-HIAA, in the brain.
Negative_regulation (lacking) of PACAP-KO in brain associated with serotonin
2) Confidence 0.56 Published 2003 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 14727506 Disease Relevance 0.13 Pain Relevance 0.11
Mice lacking PACAP (PACAP-KO) exhibits altered psychomotor behaviors, including impaired habituation to a novel environment and perseverative jumping, with a slightly reduced levels of the serotonin metabolite, 5-HIAA, in the brain.
Negative_regulation (lacking) of PACAP in brain associated with serotonin
3) Confidence 0.56 Published 2003 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 14727506 Disease Relevance 0.08 Pain Relevance 0.11
Serotonergic inhibition of intense jumping behavior in mice lacking PACAP (Adcyap1-/-).
Negative_regulation (lacking) of PACAP
4) Confidence 0.43 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 16888223 Disease Relevance 0 Pain Relevance 0.20
Mild reductions in ambient temperature dramatically increase the mortality of neonatal mice deficient in pituitary adenylate cyclase-activating polypeptide (PACAP), with the majority of animals succumbing in the second postnatal week.
Negative_regulation (deficient) of PACAP in pituitary
5) Confidence 0.43 Published 2008 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 18184762 Disease Relevance 0.26 Pain Relevance 0.09
Mild reductions in ambient temperature dramatically increase the mortality of neonatal mice deficient in pituitary adenylate cyclase-activating polypeptide (PACAP), with the majority of animals succumbing in the second postnatal week.
Negative_regulation (deficient) of pituitary adenylate cyclase-activating polypeptide in pituitary
6) Confidence 0.43 Published 2008 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 18184762 Disease Relevance 0.26 Pain Relevance 0.09
Mice lacking PACAP (Adcyap1?
Negative_regulation (lacking) of PACAP
7) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823792 Disease Relevance 0.14 Pain Relevance 0.12
These data suggest that the dysfunctions of entrainment and masking were caused by the loss of PACAP, not by the loss of light input itself.
Neg (not) Negative_regulation (loss) of PACAP
8) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2823792 Disease Relevance 0.50 Pain Relevance 0
Mice lacking PACAP (Adcyap1?
Negative_regulation (lacking) of Adcyap1
9) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823792 Disease Relevance 0.14 Pain Relevance 0.12
Here we show that mice lacking the PACAP gene (PACAP-/-) did not exhibit inflammatory pain induced by intraplantar injection of carrageenan or neuropathic pain induced by L5 spinal nerve transection, whereas they did retain normal nociceptive responses.
Negative_regulation (lacking) of PACAP in spinal nerve associated with nociception, ipn and neuropathic pain
10) Confidence 0.43 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15317855 Disease Relevance 0.83 Pain Relevance 0.80
Here we show that mice lacking the PACAP gene (PACAP-/-) did not exhibit inflammatory pain induced by intraplantar injection of carrageenan or neuropathic pain induced by L5 spinal nerve transection, whereas they did retain normal nociceptive responses.
Negative_regulation (lacking) of PACAP in spinal nerve associated with nociception, ipn and neuropathic pain
11) Confidence 0.43 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15317855 Disease Relevance 0.84 Pain Relevance 0.81
We previously observed that mice lacking the Adcyap1 gene encoding the neuropeptide PACAP (Adcyap1-/-) displayed intense jumping behavior when placed in a novel environment such as an open field.
Negative_regulation (lacking) of PACAP associated with neuropeptide
12) Confidence 0.43 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 16888223 Disease Relevance 0 Pain Relevance 0.20
We previously observed that mice lacking the Adcyap1 gene encoding the neuropeptide PACAP (Adcyap1-/-) displayed intense jumping behavior when placed in a novel environment such as an open field.
Negative_regulation (lacking) of Adcyap1 associated with neuropeptide
13) Confidence 0.43 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 16888223 Disease Relevance 0 Pain Relevance 0.20
Conversely these findings might suggest that a defect in specific PACAP/VIP function could act adversely on SN cells and, perhaps in concert with other environmental factors, contribute to a clinical presentation consistent with PD.
Negative_regulation (defect) of PACAP associated with substantia nigra and disease
14) Confidence 0.41 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 1.22 Pain Relevance 0.25
We investigated the effects of PACAP treatment, and endogenous PACAP deficiency, on infarct volume, neurological function, and the cerebrocortical transcriptional response in a mouse model of stroke, middle cerebral artery occlusion (MCAO).
Negative_regulation (deficiency) of PACAP in middle cerebral artery associated with middle cerebral artery infarction and stroke
15) Confidence 0.37 Published 2006 Journal Regul. Pept. Section Abstract Doc Link 17027094 Disease Relevance 0.44 Pain Relevance 0
[Altered behavioral response to centrally acting drugs in mice lacking PACAP].
Negative_regulation (lacking) of PACAP associated with neuropeptide
16) Confidence 0.36 Published 2003 Journal Nippon Yakurigaku Zasshi Section Title Doc Link 14727506 Disease Relevance 0.47 Pain Relevance 0.44

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