INT115890

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Context Info
Confidence 0.68
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 11.55
Pain Relevance 3.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nefh)
Anatomy Link Frequency
nerves 3
retinas 2
neurons 2
dentate gyrus 1
cerebrospinal fluid 1
Nefh (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 17 100.00 Very High Very High Very High
Multiple sclerosis 32 99.56 Very High Very High Very High
Lasting pain 20 99.48 Very High Very High Very High
unmyelinated 11 98.44 Very High Very High Very High
Pain 67 96.16 Very High Very High Very High
qutenza 26 96.12 Very High Very High Very High
Neuritis 17 95.88 Very High Very High Very High
dorsal root ganglion 123 93.68 High High
Spinal cord 105 93.48 High High
nociceptor 54 91.36 High High
Disease Link Frequency Relevance Heat
Glomus Tumor 6 100.00 Very High Very High Very High
Leber Hereditary Optic Atrophy 288 99.64 Very High Very High Very High
Demyelinating Disease 30 99.56 Very High Very High Very High
Pain 82 99.48 Very High Very High Very High
Injury 171 99.08 Very High Very High Very High
Multiple Sclerosis 12 98.28 Very High Very High Very High
Disease 121 97.68 Very High Very High Very High
Pressure And Volume Under Development 37 97.00 Very High Very High Very High
Neuritis 5 95.88 Very High Very High Very High
Death 100 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: To observe the expression and distribution of substance P (SP), neurofilament-H (NFH) in glomus tumors with chronic pain, and to discuss the process of chronic pain and the relationship with pain degree.
Gene_expression (expression) of NFH in glomus associated with glomus tumor, pain, lasting pain and substance p
1) Confidence 0.68 Published 2003 Journal Zhonghua Wai Ke Za Zhi Section Abstract Doc Link 14728838 Disease Relevance 0.54 Pain Relevance 0.46
Immunohistochemical methods were used to determine the expression of SP, NFH which were detected quantitatively by computer graph analysis system too.
Spec (determine) Gene_expression (expression) of NFH
2) Confidence 0.68 Published 2003 Journal Zhonghua Wai Ke Za Zhi Section Body Doc Link 14728838 Disease Relevance 0.24 Pain Relevance 0
These cells colocalized predominantly with NF200 (Fig. 8B) and not with peripherin (data not shown).
Neg (not) Gene_expression (with) of NF200
3) Confidence 0.65 Published 2009 Journal Mol Pain Section Body Doc Link PMC2747840 Disease Relevance 0.51 Pain Relevance 0.18
Axonal injury was a severe and acute event, insofar as serum pNF-H levels were not significantly elevated at early (EAE day 12) or late (EAE days 35 and 50) disease time points.
Gene_expression (levels) of pNF-H associated with multiple sclerosis, injury and disease
4) Confidence 0.65 Published 2008 Journal J. Neurosci. Res. Section Abstract Doc Link 18709652 Disease Relevance 1.96 Pain Relevance 0.29
RESULTS: The positive expression and distribution of SP, NFH existed in all the three groups and SPSG expression level was the highest [Grayscale Value(SP) (143.3 +/- 7.5), Grayscale Value(NFH) (167.7 +/- 4.4)], LPSG followed [Grayscale Value(SP) (156.2 +/- 8.2), Grayscale Value(NFH) (194.8 +/- 4.0)], control group was the third [Grayscale Value(SP) (208.2 +/- 16.6), Grayscale Value(NFH) (225.1 +/- 8.3)]; The difference of expression level among three groups was significant [SPSG vs LPSG (P(SP) = 0.002, P(NFH) < 0.0001), SPSG vs CG (P(SP) < 0.0001, P(NFH) < 0.0001), LPSG vs CG (P(SP) < 0.0001, P(NFH) < 0.0001)].
Gene_expression (expression) of NFH
5) Confidence 0.46 Published 2003 Journal Zhonghua Wai Ke Za Zhi Section Body Doc Link 14728838 Disease Relevance 0.18 Pain Relevance 0
Only a small fraction (around 6%) of these NFH+ neurons also expressed functional TRPV1 receptors, as demonstrated by a calcium increase in response to application of capsaicin (see white bar at bottom of second bar in Fig. 6B), showing that this class of thrombin-responsive large neurons is predominantly non-nociceptive.
Gene_expression (expressed) of NFH in neurons associated with nociception and qutenza
6) Confidence 0.33 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.09 Pain Relevance 0.26
Following the memory retention test, the levels of P-NF-H, MAP2, synaptophysin and myelin basic protein (MBP, a myelin marker) were measured in the brains of the mice by immunohistochemistry.
Gene_expression (levels) of P-NF-H in brains
7) Confidence 0.27 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.26 Pain Relevance 0.14
(25–35)-injected mice receiving vehicle compared to control mice, and administration of Kihi-to resulted in significant increases in P-NF-H expression levels in CA1 radiatum, dentate gyrus, parietal cortex, perirhinal cortex and the striatum (Figures 3 and 7).
Gene_expression (expression) of P-NF-H in parietal cortex
8) Confidence 0.27 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.20 Pain Relevance 0.09
Expression levels of P-NF-H were decreased in all regions of A?
Gene_expression (Expression) of P-NF-H
9) Confidence 0.27 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.22 Pain Relevance 0.11
Fig. 7GFP+ RPC migration, integration, and differentiation in host retina 30 days following subretinal transplantation. a, b Transplanted GFP+ RPC soma migrate into each retinal layer and co-label for GFAP (red). a RPC migrated into GCL extend visible processes into IPL (arrow). b Smaller RPCs migrated into ONL and appear to have short processes in the OPL region (arrows). c, d Transplanted RPCs integrate into the OPL region of host retina expressing normal levels of NF-200 (c) and recoverin (d)Fig. 8GFP+ RPC migration, integration and differentiation in Rho?
Gene_expression (expressing) of NF-200 in retinal layer
10) Confidence 0.18 Published 2008 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2802414 Disease Relevance 0 Pain Relevance 0
During axon regeneration, the developmental pattern of IFs resumes: Vimentin is re-upregulated and expression of mature IFs such as NF-L and NF-H decreases [11]–[15], [17], [27], [32].
Gene_expression (expression) of NF-H
11) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.32 Pain Relevance 0.07
However, decreased regeneration associated with lowered levels of GAP-43, Vimentin and NF-H was observed.
Gene_expression (levels) of NF-H
12) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.15 Pain Relevance 0.05
GFP-immunoreactive neuronal profiles in the DRG were rarely (<3%) immunoreactive for neurofilament-200 (NF200) a marker of primary sensory neurons that give rise to myelinated axons [12].
Gene_expression (profiles) of neurofilament-200 in primary sensory neurons
13) Confidence 0.14 Published 2006 Journal Mol Pain Section Body Doc Link PMC1479315 Disease Relevance 0.30 Pain Relevance 0.60
Conversely, NF200-immunoreactive DRG neurons were not (<1%) immunoreactive for GFP (Figure 1A–C and Figure 2).
Gene_expression (neurons) of NF200-immunoreactive in neurons
14) Confidence 0.14 Published 2006 Journal Mol Pain Section Body Doc Link PMC1479315 Disease Relevance 0.27 Pain Relevance 0.64
Consistently, levels of Neurofilament H (NF-H), a late marker for axonal maturation, were severely reduced in the Ndel1 siRNA-injected nerves.
Gene_expression (levels) of NF-H in nerves
15) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.18 Pain Relevance 0
This was demonstrated by a reduction in levels of Vimentin and GAP-43, a marker for axonal regeneration, as well as NF-H, a late marker for axonal maturation in Ndel1 siRNA treated nerves (Fig. 6).
Gene_expression (levels) of NF-H in nerves
16) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.09 Pain Relevance 0
Consistently, levels of Neurofilament H (NF-H), a late marker for axonal maturation, were severely reduced in the Ndel1 siRNA-injected nerves.
Gene_expression (levels) of Neurofilament H in nerves
17) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.18 Pain Relevance 0
fibers because they express NF200, a marker of myelinated axons [43], whereas we saw no evidence that CGRP-positive small-caliber (C) arterial axons express ASIC3 or TRPV1.
Gene_expression (express) of NF200
18) Confidence 0.10 Published 2005 Journal Mol Pain Section Body Doc Link PMC1308857 Disease Relevance 0.48 Pain Relevance 0.29
There was no correlation between age and pNF-H levels in the off-pedigree group: age (r=0.03, p=0.87), quadratic age (r=0.04, p=0.84).
Gene_expression (levels) of pNF-H
19) Confidence 0.09 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605731 Disease Relevance 0.35 Pain Relevance 0
(25–35)-injected mice receiving vehicle compared to control mice, and administration of Kihi-to resulted in significant increases in P-NF-H expression levels in CA1 radiatum, dentate gyrus, parietal cortex, perirhinal cortex and the striatum (Figures 3 and 7).
Gene_expression (expression) of P-NF-H in dentate gyrus
20) Confidence 0.09 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.20 Pain Relevance 0.09

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