INT115909

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 16.58
Pain Relevance 27.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 6
sciatic nerve 6
nerve 4
muscle 2
dorsal horn 2
Nav1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nav1.3 362 100.00 Very High Very High Very High
sodium channel 251 100.00 Very High Very High Very High
nav1.8 221 100.00 Very High Very High Very High
Nav1.6 170 100.00 Very High Very High Very High
Nav1.1 74 100.00 Very High Very High Very High
Nav1.9 25 100.00 Very High Very High Very High
Eae 467 99.98 Very High Very High Very High
Pyramidal cell 8 99.60 Very High Very High Very High
Dorsal horn neuron 61 99.52 Very High Very High Very High
Sciatic nerve 268 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuroma 87 100.00 Very High Very High Very High
Inflammatory Pain 6 99.98 Very High Very High Very High
Injury 681 99.80 Very High Very High Very High
INFLAMMATION 21 99.44 Very High Very High Very High
Heart Rate Under Development 18 99.16 Very High Very High Very High
Cancer Pain 48 99.08 Very High Very High Very High
Neuropathic Pain 159 98.60 Very High Very High Very High
Hyperalgesia 56 98.04 Very High Very High Very High
Pain 192 98.00 Very High Very High Very High
Spinal Cord Injury 42 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The massive increase in Nav1.8 expression in myelinated axons suggests that these may contribute to peripheral sensitization and inflammatory hyperalgesia.
Positive_regulation (increase) of Gene_expression (expression) of Nav1 associated with hyperalgesia, inflammation, peripheral sensitization and nav1.8
1) Confidence 0.70 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 14729231 Disease Relevance 0.38 Pain Relevance 1.48
Increased expression of Nav1.3 occurs in DRG and dorsal horn neurons following injury to the sciatic nerve [6,7,9,36,37], and while expression of Nav1.3 is not increased in axotomized cortical pyramidal neurons [38].
Positive_regulation (Increased) of Gene_expression (expression) of Nav1 in sciatic nerve associated with nav1.3, pyramidal cell, injury, sciatic nerve and dorsal horn neuron
2) Confidence 0.70 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 0.89 Pain Relevance 1.93
Increased expression of Nav1.3 occurs in DRG and dorsal horn neurons following injury to the sciatic nerve [6,7,9,36,37], and while expression of Nav1.3 is not increased in axotomized cortical pyramidal neurons [38].
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of Nav1 in sciatic nerve associated with nav1.3, pyramidal cell, injury, sciatic nerve and dorsal horn neuron
3) Confidence 0.70 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 1.00 Pain Relevance 1.95
The increased expression of NaV1.3 implicates this subtype in the development and maintenance of neuropathic pain, but its contribution to neuropathic pain behavior has not been examined.
Positive_regulation (increased) of Gene_expression (expression) of NaV1 associated with neuropathic pain
4) Confidence 0.70 Published 2005 Journal Pain Section Abstract Doc Link 16061326 Disease Relevance 0.61 Pain Relevance 0.61
In this cancer pain model of rats, the contribution of the Nav1.8 channel activity to the maintenance of cancer pain does not appear to be directly related to an enhanced synthesis of Nav1.8 in the primary afferent nerve.
Positive_regulation (enhanced) of Gene_expression (synthesis) of Nav1 in nerve associated with cancer pain and nav1.8
5) Confidence 0.69 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894792 Disease Relevance 1.62 Pain Relevance 1.98
Upregulated expression of sodium channel Nav1.3 has been observed within the spinal dorsal horn neurons after SCI, and appears to contribute to neuronal hyperresponsiveness and pain-related behaviors.
Spec (appears) Positive_regulation (Upregulated) of Gene_expression (expression) of Nav1 in neuronal associated with pain, nav1.3, spinal cord injury, sodium channel and dorsal horn neuron
6) Confidence 0.69 Published 2006 Journal Exp Brain Res Section Abstract Doc Link 16718433 Disease Relevance 0.84 Pain Relevance 0.62
The whole cell configuration of the patch clamp technique was used to record Na currents from human embryonal kidney cells stably transfected with Nav1.4 channels.
Positive_regulation (transfected) of Gene_expression (transfected) of Nav1 in kidney
7) Confidence 0.50 Published 2005 Journal Anesthesiology Section Body Doc Link 16306739 Disease Relevance 0 Pain Relevance 0
Nav1.3 recovers from inactivation rapidly and produces a depolarizing response to small stimuli close to resting potential, and produces a persistent current – increasing the excitability of cells that express Nav1.3 [7,10-12].
Positive_regulation (response) of Gene_expression (produces) of Nav1 associated with nav1.3
8) Confidence 0.50 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 0.61 Pain Relevance 1.60
It is known that after peripheral nerve injury 2-deoxyglucose metabolic activity [32] and regional blood flow [33] are increased in the thalamus, and that changes in cannabinoid receptors [34] and monoamine release [35] occur, but whether these are linked to Nav1.3 expression is unclear.
Positive_regulation (linked) of Gene_expression (expression) of Nav1 in blood associated with nav1.3, nervous system injury, cannabinoid receptor, thalamus, monoamine and peripheral nerve injury
9) Confidence 0.50 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 0.38 Pain Relevance 1.36
Qualitative observations of Nav1.6 and caspr staining patterns and relationships in normal vs. lesioned IONs
Positive_regulation (observations) of Gene_expression (patterns) of Nav1.6 associated with nav1.6
10) Confidence 0.50 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1941742 Disease Relevance 0.30 Pain Relevance 0.51
Carrageenan-induced inflammatory pain increases Nav1.8 mRNA expression and the density of TTX-R currents [12].
Positive_regulation (increases) of Gene_expression (expression) of Nav1 associated with tetrodotoxin, eae and nav1.8
11) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894792 Disease Relevance 0.97 Pain Relevance 2.40
Activation of p38 in the neuronal ND7/23 cell line transfected with Nav1.6 leads to a significant reduction in the peak Nav1.6 current amplitude, without a detectable effect on gating properties.
Positive_regulation (transfected) of Gene_expression (transfected) of Nav1 in neuronal associated with nav1.6
12) Confidence 0.50 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16014723 Disease Relevance 0.21 Pain Relevance 1.03
Activation of p38 in the neuronal ND7/23 cell line transfected with Nav1.6 leads to a significant reduction in the peak Nav1.6 current amplitude, without a detectable effect on gating properties.
Positive_regulation (Activation) of Gene_expression (transfected) of Nav1 in neuronal associated with nav1.6
13) Confidence 0.50 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16014723 Disease Relevance 0.22 Pain Relevance 1.05
1-adrenergic receptor antagonist prazosin suggested that part of this response is mediated through activation of Nav channels in sympathetic perivascular nerve-terminals.
Positive_regulation (activation) of Gene_expression (channels) of Nav in nerve associated with antagonist
14) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2752992 Disease Relevance 0 Pain Relevance 0.46
These data suggest that most of the vasoconstrictive response observed at the lowest KCl concentrations is mediated by Nav channels.
Positive_regulation (mediated) of Gene_expression (channels) of Nav
15) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2752992 Disease Relevance 0 Pain Relevance 0.54
In the WAG/Rij model of absence epilepsy, we identified a specific region of cortex, in layer II-IV neurons on the lateral convexity of the cortex in the facial somatosensory area, where mRNA and protein expression of sodium channel genes Nav1.1 and Nav1.6 are up-regulated.
Positive_regulation (up-regulated) of Gene_expression (expression) of Nav1 in cortex associated with nav1.1, sodium channel, absence epilepsy and nav1.6
16) Confidence 0.47 Published 2004 Journal Brain Res. Section Abstract Doc Link 15053958 Disease Relevance 0.33 Pain Relevance 0.97
Increased expression of Nav1.3 occurs in DRG and dorsal horn neurons following injury to the sciatic nerve [6,7,9,36,37], and while expression of Nav1.3 is not increased in axotomized cortical pyramidal neurons [38].
Positive_regulation (occurs) of Gene_expression (expression) of Nav1 in sciatic nerve associated with nav1.3, pyramidal cell, injury, sciatic nerve and dorsal horn neuron
17) Confidence 0.47 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 0.89 Pain Relevance 1.93
Up-regulation of Nav1.3 expression in DRG neurons is associated with allodynia and hyperalgesia [8].
Positive_regulation (regulation) of Gene_expression (expression) of Nav1 in neurons associated with nav1.3, hyperalgesia and allodynia
18) Confidence 0.47 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 0.95 Pain Relevance 2.00
We hypothesized that upregulated expression of Nav1.3, and possibly other isoforms, occurs in third-order VPL neurons after peripheral nerve injury.


Positive_regulation (upregulated) of Gene_expression (expression) of Nav1 in peripheral nerve associated with nav1.3, nervous system injury and peripheral nerve injury
19) Confidence 0.47 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 1.08 Pain Relevance 1.02
It is now well-established that peripheral axotomy and chronic constriction injury (CCI) trigger upregulated expression of the Nav1.3 sodium channel within DRG neurons [6-8] and that CCI is followed by upregulation of Nav1.3 within nociceptive dorsal horn neurons [9].
Positive_regulation (upregulated) of Gene_expression (expression) of Nav1 in dorsal horn associated with nociception, nav1.3, eae, injury, sodium channel and dorsal horn neuron
20) Confidence 0.41 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 0.97 Pain Relevance 1.13

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