INT11591

Context Info Confidence 0.65 First Reported 1990 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 53 Total Number 54 Disease Relevance 23.14 Pain Relevance 6.73

Anatomy Link Frequency radial 1 Th1 cells 1 CII 1 lung 1 Th2 cells 1 IgG2a (Mus musculus)

Pain Link Frequency Relevance Heat Kappa opioid receptor 8 99.76 chemokine 50 99.04 Arthritis 154 99.02 cytokine 677 98.80 Inflammation 442 98.18 dexamethasone 20 98.16 anesthesia 39 98.00 methotrexate 29 97.76 cINOD 9 97.68 Enkephalin 8 97.40

Disease Link Frequency Relevance Heat Aspergillus Infection 132 100.00 Sprains And Strains 408 99.80 Candida Infection 274 99.52 Arthritis 170 99.02 Infection 281 98.92 Immunization 617 98.84 INFLAMMATION 518 98.18 Hypersensitivity 277 97.78 Chlamydia Infection 69 97.40 Yersinia Infection 118 97.16

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Anatomy

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Disease term

Compared to wild-type (WT) mice, KOR-/- animals produced significant higher levels of antigen-specific total Ig, IgM, IgG1 and IgG2a antibodies.

Gene_expression (produced) of IgG2a associated with kappa opioid receptor

1) Confidence 0.65 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12507774 Disease Relevance 0.25 Pain Relevance 0.57

Administration of indomethacin resulted in suppression of antigen (OVA)-induced arthritis that was associated with inhibition of anti-OVA IgG2a but not IgG1 production.

Gene_expression (production) of IgG2a associated with arthritis

2) Confidence 0.51 Published 2003 Journal J Pharm Sci Section Abstract Doc Link 12884258 Disease Relevance 0.33 Pain Relevance 0.38

Treatments with IND, DEX, MTX and AUR inhibited both Th1 and Th2 immune responses, although the inhibitory effects of these drugs on the antigen-specific IgG2a and IFN-gamma production appeared to be greater than those on IgG1 and IL-10 production.

Gene_expression (production) of IgG2a associated with methotrexate and dexamethasone

3) Confidence 0.47 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.55 Pain Relevance 0.57

Administrations of all the drugs used resulted in suppression of antigen (OVA)-induced arthritis in mice which was associated with inhibition of anti-OVA IgG2a but not IgG1 production.

Gene_expression (production) of IgG2a associated with arthritis

4) Confidence 0.47 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.56 Pain Relevance 0.57

D-PA failed to influence anti-OVA IgG, IgG2a and IgG1 production as well as IFN-gamma and IL-10 secretion.

Gene_expression (production) of IgG2a

5) Confidence 0.47 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.58 Pain Relevance 0.57

Results show that proliferation was not affected by either peptide, but that IgM, IgG3 and IgG2a production were inhibited in a concentration- and time-dependent manner by MENK.

Gene_expression (production) of IgG2a associated with enkephalin

6) Confidence 0.45 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9058757 Disease Relevance 0 Pain Relevance 0.45

Antibody concentrations (ng per g lung tissues or ng per ml sera) were determined using standard curves for mouse IgG1 and IgG2a antibodies.

Gene_expression (antibodies) of IgG2a in lung

7) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745577 Disease Relevance 0.50 Pain Relevance 0.09

ELISA for detection of IgE, IgG1 and IgG2a anti-OVA antibodies

Gene_expression (detection) of IgG2a

8) Confidence 0.43 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.24 Pain Relevance 0.04

On day 21, anti-OVA IgG2a and interferon (IFN)-gamma as indicators of Th1 responses and anti-OVA IgG1 and interleukin (IL)-10 as those of Th2 responses were measured.

Gene_expression (measured) of IgG2a

9) Confidence 0.41 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.39 Pain Relevance 0.49

There were no significant differences between the levels of Af-specific IgE (Fig 2C) and IgG2a (not shown) between the two mouse strains.

Gene_expression (levels) of IgG2a associated with sprains and strains and aspergillus infection

10) Confidence 0.39 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 1.29 Pain Relevance 0.06

production is associated with IgG2a production [37].

Gene_expression (production) of IgG2a

11) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.17 Pain Relevance 0

Higher levels of both recall serum IgG1 and IgG2a antibodies were also observed in the group immunized by microneedle delivery with trehalose-formulated vaccine (MN+T) than those in the corresponding inramuscular immunization groups (p<0.05 between MN+T and IM+T for both IgG1 and IgG2a) (Fig. 7B and Table 2).

Gene_expression (antibodies) of IgG2a associated with immunization

12) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745577 Disease Relevance 0.92 Pain Relevance 0.03

Also the IgG2a levels were significantly higher for OVA with all particle doses than for OVA alone, and significantly higher antibody levels were observed with 40 ?

Gene_expression (levels) of IgG2a

13) Confidence 0.38 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.21 Pain Relevance 0

IgG2a levels were similar in both WT (118 ± 15 ?

Gene_expression (levels) of IgG2a

14) Confidence 0.37 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.06 Pain Relevance 0

For IgG1 and IgG2a titrations, purified IgG1 or IgG2a antibody of a known concentration was used respectively.

Gene_expression (titrations) of IgG2a

15) Confidence 0.37 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0

That is, the average IgG2a titers in all three injected groups were lower than that of normal control group.

Gene_expression (titers) of IgG2a

16) Confidence 0.37 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0.16 Pain Relevance 0

The IgG1/IgG2a ratio, which is considered a measure for the Th1/Th2 balance of the immune response (27), of individual mice from each group after the second boost was calculated and presented in Fig. 3.

Gene_expression (presented) of IgG2a

17) Confidence 0.37 Published 2009 Journal Pharm Res Section Body Doc Link PMC2689355 Disease Relevance 0.35 Pain Relevance 0

Fig. 3.DT-specific IgG1/IgG2a ratios of individual mouse after M-TCI.

Gene_expression (ratios) of IgG2a associated with immunization

18) Confidence 0.37 Published 2009 Journal Pharm Res Section Body Doc Link PMC2689355 Disease Relevance 0.39 Pain Relevance 0

This was confirmed by the comparison between CpG and CT groups, also showing that higher IgG2a titers did not result in higher neutralizing antibody titers.

Gene_expression (titers) of IgG2a

19) Confidence 0.37 Published 2009 Journal Pharm Res Section Body Doc Link PMC2689355 Disease Relevance 0.32 Pain Relevance 0

Subclass determination showed that the clones produced IgG1, IgG2a, IgG3, and IgM types of antibody.

Gene_expression (produced) of IgG2a

20) Confidence 0.36 Published 2002 Journal Hybrid. Hybridomics Section Abstract Doc Link 12165146 Disease Relevance 0.07 Pain Relevance 0.29

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