INT115921

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 22
Total Number 25
Disease Relevance 12.03
Pain Relevance 3.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

immune system process (AHR) cell morphogenesis (AHR) DNA binding (AHR)
response to stress (AHR) cytoplasm (AHR) signal transducer activity (AHR)
Anatomy Link Frequency
monocytes 1
B cells 1
1A2 1
basement membrane 1
eosinophil 1
AHR (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 384 99.86 Very High Very High Very High
bradykinin 182 99.84 Very High Very High Very High
Inflammation 216 99.16 Very High Very High Very High
qutenza 4 94.92 High High
b2 receptor 140 91.64 High High
cytokine 35 91.44 High High
antagonist 113 88.88 High High
cINOD 18 76.80 Quite High
Bile 4 75.00 Quite High
aspirin 31 72.68 Quite High
Disease Link Frequency Relevance Heat
Nicotine Addiction 68 99.98 Very High Very High Very High
Rhinitis 65 99.96 Very High Very High Very High
Asthma 475 99.64 Very High Very High Very High
Occupational Lung Diseases 48 99.32 Very High Very High Very High
INFLAMMATION 233 99.16 Very High Very High Very High
Targeted Disruption 5 98.64 Very High Very High Very High
Adhesions 14 98.04 Very High Very High Very High
Cancer 33 97.16 Very High Very High Very High
Eosinophilia 11 94.36 High High
Hypoxia 74 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A xenobiotic response element regulating aryl hydrocarbon receptor (AhR)-mediated UGT1A3 transcription was identified and characterized.
Positive_regulation (-mediated) of AhR
1) Confidence 0.49 Published 2008 Journal Arch. Toxicol. Section Abstract Doc Link 18677463 Disease Relevance 0.08 Pain Relevance 0.15
A xenobiotic response element regulating aryl hydrocarbon receptor (AhR)-mediated UGT1A3 transcription was identified and characterized.
Positive_regulation (-mediated) of aryl hydrocarbon receptor
2) Confidence 0.49 Published 2008 Journal Arch. Toxicol. Section Abstract Doc Link 18677463 Disease Relevance 0.08 Pain Relevance 0.15
The detrimental effects of TCDD are mediated via the aryl hydrocarbon receptor (AhR), a transcription factor that regulates the expression of the carcinogen-activating enzymes cytochromes P-450 (CYP) 1A1, 1A2, and 1B1.
Positive_regulation (mediated) of aryl hydrocarbon receptor in 1A2
3) Confidence 0.43 Published 2004 Journal Cancer Res. Section Abstract Doc Link 14729655 Disease Relevance 0.17 Pain Relevance 0.17
Also the AhR target genes CYP1A1 and CYP1B1 were upregulated by the aglycon mixture and with actein albeit at a lower level.


Positive_regulation (upregulated) of AhR
4) Confidence 0.32 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.23 Pain Relevance 0
Interestingly, transcription of the aryl hydrocarbon receptor (AhR) which regulates expression of the CYPs, was also increased.
Positive_regulation (increased) of aryl hydrocarbon receptor
5) Confidence 0.32 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.57 Pain Relevance 0
Because these mediators are key components of allergen-induced airway responses, we wanted to determine if toxin challenge would induce a LAR and AHR similar to that seen with allergen.
Positive_regulation (induce) of AHR
6) Confidence 0.31 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257560 Disease Relevance 0.06 Pain Relevance 0.07
On the next day, we measured their PC400 to carbachol to determine if the postantigen-induced AHR was affected.
Positive_regulation (induced) of AHR
7) Confidence 0.31 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257560 Disease Relevance 0 Pain Relevance 0
Ligand activation of AHR results in dimerisation with ARNT with subsequent binding to XRE.
Positive_regulation (activation) of AHR
8) Confidence 0.25 Published 2010 Journal BMC Med Section Body Doc Link PMC2955589 Disease Relevance 0.52 Pain Relevance 0
Though OVA-induced increases in AHR to nonspecific stimuli were not mediated by mMBP-1, this model may not require eosinophil degranulation for observed increases in AHR, the temporal and spatial release of MBP may not elicit an AHR response, or other eosinophil-derived granule protein may be responsible for AHR.
Positive_regulation (increases) of AHR in eosinophil
9) Confidence 0.25 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0.49 Pain Relevance 0.06
Moreover, these investigators determined that, in antigen-challenged guinea pigs, MBP may allosterically bind to M2 muscarinics receptor thereby inducing AHR in vivo [48, 49].
Positive_regulation (inducing) of AHR
10) Confidence 0.25 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0.29 Pain Relevance 0.06
We found that although PbTx-3 (20 breaths of 100 pg/mL) caused an early bronchoconstriction, there was no subsequent LAR or AHR in sheep that demonstrated these responses to inhaled allergen (data not shown).
Neg (no) Positive_regulation (subsequent) of AHR
11) Confidence 0.23 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257560 Disease Relevance 0 Pain Relevance 0.03
To determine if toxin exposure would enhance the response to allergen and/or affect the postantigen-induced AHR, we exposed three sheep to PbTx-3 (20 breaths of 100 pg/mL) for 3 consecutive days and then, on the day 4, measured the response to allergen challenge.
Positive_regulation (induced) of AHR
12) Confidence 0.23 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257560 Disease Relevance 0 Pain Relevance 0.03
In ethnic German populations, the IL-13 Arg110Gln variant has a significant association with high IgE levels.13 In addition, this allele was associated with the asthma phenotype in British and Japanese populations.14 Moreover, IL-13 is necessary and sufficient for the induction of AHR eosinophilic airway inflammation; in the absence of IL-13, this does not progress to AHR.
Positive_regulation (induction) of AHR associated with asthma, rhinitis and inflammation
13) Confidence 0.22 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.29 Pain Relevance 0.09
To determine if multiple exposures to PbTx-3 affected antigen-induced responses, we challenged sheep in the morning with 20 breaths of 100 pg/mL PbTx-3 for 3 consecutive days and then on the fourth day challenged the animals with allergen to determine if the antigen-induced EAR, LAR, and AHR were affected.
Positive_regulation (induced) of AHR
14) Confidence 0.21 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257560 Disease Relevance 0 Pain Relevance 0.11
These findings indicate that, although toxin elicits an acute bronchoconstriction, the stimulus and/ or signaling mechanisms are not the same as seen with allergen that can result in a LAR and AHR.
Positive_regulation (result) of AHR
15) Confidence 0.21 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257560 Disease Relevance 0 Pain Relevance 0.03
Genes sharing the regulatory xenobiotic response element (XRE) for the aryl hydrocarbon receptor (AHR)/AhR nuclear translocator (ARNT) were upregulated in both intervention groups.
Positive_regulation (upregulated) of aryl hydrocarbon receptor
16) Confidence 0.17 Published 2010 Journal BMC Med Section Body Doc Link PMC2955589 Disease Relevance 0.52 Pain Relevance 0
Genes with common regulatory motifs for aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (AhR/ARNT) were upregulated by both interventions (FDR q-values < 5%).
Positive_regulation (upregulated) of AhR
17) Confidence 0.17 Published 2010 Journal BMC Med Section Abstract Doc Link PMC2955589 Disease Relevance 0.47 Pain Relevance 0
Genes with common regulatory motifs for aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (AhR/ARNT) were upregulated by both interventions (FDR q-values < 5%).
Positive_regulation (upregulated) of aryl hydrocarbon receptor
18) Confidence 0.17 Published 2010 Journal BMC Med Section Abstract Doc Link PMC2955589 Disease Relevance 0.53 Pain Relevance 0
Functional studies have demonstrated a regulatory role of substituted 110Gln in addition to the involvement of Stat-6 in monocytes, decreased IL-13 receptor alpha-2 affinity for IL-13, and increased expression of IL-13 in patients with asthma,22,23 as well as AHR induction in a murine model of asthma.24 By contrast, our findings suggest that the GG genotype is associated with a risk of eosinophilic infiltration and the development of AIA.
Positive_regulation (induction) of AHR in monocytes associated with asthma and rhinitis
19) Confidence 0.15 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.31 Pain Relevance 0.03
IL-13 is a critical cytokine in the pathogenesis of allergic asthma in a mouse model of asthma,3 and is involved in several physiological changes, such as airway eosinophilia and hyper-responsiveness.4 In humans, CD4+T cells, eosinophils, mast cells, basophils, and natural killer T cells produce IL-13, inducing IgG4 and IgE synthesis in cultured B cells.5 IL-13 mRNA and protein are increased in the sputum of asthmatics and have been correlated with an increased eosinophil count6 and airway hyper-responsiveness (AHR).7 In addition, the expression of vascular cell adhesion molecule-1 (VCAM-I) is upregulated in endothelial cells, which may contribute to eosinophil migration into airway tissues.8
Positive_regulation (increased) of AHR in B cells associated with asthma, occupational lung diseases, adhesions, eosinophilia and cytokine
20) Confidence 0.15 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.83 Pain Relevance 0.34

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