INT115938

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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.27
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos1) aging (Nos1) enzyme binding (Nos1)
cytoplasm (Nos1) cytosol (Nos1) oxidoreductase activity (Nos1)
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 11 99.98 Very High Very High Very High
Antinociceptive 5 99.28 Very High Very High Very High
Intracerebroventricular 1 98.54 Very High Very High Very High
depression 3 98.12 Very High Very High Very High
intrathecal 1 97.90 Very High Very High Very High
Paracetamol 2 92.88 High High
Dextromethorphan 3 92.04 High High
Hippocampus 1 75.00 Quite High
Neuronal nitric oxide synthase 1 59.00 Quite High
cINOD 1 48.88 Quite Low
Disease Link Frequency Relevance Heat
Depression 3 98.12 Very High Very High Very High
Opiate Addiction 1 42.56 Quite Low
Nociception 1 30.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collectively, the study demonstrates that maternal exposure to morphine decreases the magnitude of PSD-95, nNOS, the phosphorylation of CREB(Serine-133), and LTD expression in hippocampal CA1 subregion of young offspring (e.g., P14).
Negative_regulation (decreases) of Negative_regulation (magnitude) of nNOS associated with depression and morphine
1) Confidence 0.36 Published 2006 Journal Hippocampus Section Abstract Doc Link 16598705 Disease Relevance 0.27 Pain Relevance 0.93
Results obtained in this study indicate that intrathecal (it) or intracerebroventricular (icv) pretreatment with LG-nitro-L-arginine (L-NO-Arg), a non-selective inhibitor of NOS activity, as well as with 7-nitroindazole (7-NI), a selective nNOS inhibitor, potentiated the antinociceptive activity of subceiling doses of ACETA, but were without effect on the action of supramaximal doses in Randall-Selitto test.
Negative_regulation (inhibitor) of Negative_regulation (inhibitor) of nNOS associated with antinociceptive, intracerebroventricular and intrathecal
2) Confidence 0.05 Published 2003 Journal Pol J Pharmacol Section Abstract Doc Link 14730095 Disease Relevance 0 Pain Relevance 0.38

General Comments

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